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Low carb diet leads to “clinical remission” in 3 cases of type 1 diabetes

diabetes.co.uk

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Re: Low carb diet leads to “clinical remission” in 3 cases of type 1 diabetes

#101

Post by arkades »

entitydc wrote: post #53
rhinoceraptor wrote: post #35

Earlier quoted context omitted.

Hugely reducing insulin dosing is still probably valuable, especially for Americans since it's so expensive.

It’s not without tradeoffs. There’s a substantial overlap between T1 and CHD, and the impacts of keto on CHD in non-normal populations (hyper-responders, metabolic patients) are even more poorly understood than they are in the general population. Lowering carbs is one thing; LCHF is an entirely different beast (and I say this both as a T1 and a T1 who tried LCHF for nearly a year). It’s an option for some, but billin…

What does CHD stand for in this context?

Re: Low carb diet leads to “clinical remission” in 3 cases of type 1 diabetes

#102

Post by eebynight »

JamesBarney wrote: post #91
PKop wrote: post #28

Earlier quoted context omitted.

Your assumptions about high cholesterol being bad are wrong, simple as that. Just as a few decades ago, the popular (even as agreed upon within medical industry) assumptions about "low fat" were wrong. In other words, the measurement you observed was good . Your brain needs that measured value you were tested at to be high. Your health would suffer if it wasn't. There is tons of research and discussion about this onl…

Just an addendum to people who aren't familiar with medical research. This is way outside of mainstream medical practice, and 95% of researchers in the field believe cholesterol matters, statins have saved more lives than any other drug, and they improve cognition in most cases.

You must not know too many people that have taken statins...

Sure, on paper, the LDL number goes down and according to the numbers you have a lower risk of heart attack, but the one common thing I've notice is that everyone complains that they feel terrible. Things like dizziness, nausea, low energy/libido, etc...

Let's not forget that it takes mainstream science time to catch up to new research. There is a lag in existing beliefs while more research is being done and evidence solidified.

That being said, lipidology is extremely complex but in the case of low carbohydrate diets the issue of having high LDL and HDL may not be as bad as mainstream medicine would make it out to be.

For some interesting insights on research being conducted in this field, Thomas Dayspring and Dave Feldman are extremely knowledgable and explain things quite well.

https://twitter.com/Drlipid

https://cholesterolcode.com/

They both have appeared on a number of health/fitness related podcasts but a quality one they both have been on is "The Drive" by Peter Attia:

https://peterattiamd.com/tomdayspring1/

https://peterattiamd.com/davefeldman/

edit: I would also argue that his subjective feelings of good health are a much better indicator than the population-averaged cholesterol numbers...

edit2: to say that this type of research is outside of mainstream medical advice is misleading. Lipodology is a prominent topic and a quick pubmed search for the "lipid" keyword since 2018 shows over 60k results. In medicine there is rarely a such thing as "settled" science. Things are continuously researched with new questions and information is used to update our original hypothesis. To refer to current advice as set in stone is very naive...

Re: Low carb diet leads to “clinical remission” in 3 cases of type 1 diabetes

#103

Post by headShrinker »

Trasmatta wrote: post #21

I'm a type 1 diabetic and find these articles and studies frustrating. Or at least the way people interpret them. > Two weeks after adopting the low carb approach insulin was no longer needed. After 18 months insulin therapy was once again required at low doses of around 16 units per day. HbA1c remained very well controlled on the LCHF diet with insulin. So during the honeymoon period, he was able to live without ins…

...

Re: Low carb diet leads to “clinical remission” in 3 cases of type 1 diabetes

#104

Post by wincy »

messe wrote: post #97
inetsee wrote: post #94

Earlier quoted context omitted.

These prices are not high. I went through a period when I had no health insurance, and I had to rely on generic insulin, the kind you can buy at Walmart for $25 a vial. I have insurance now and the insulin I take now costs me a co-pay of $100 a vial. Paying $35 a vial without insurance is not bad at all.

It's a hell of a lot higher than most developed nations. Here in Ireland, as far as I'm aware, it's free thanks to the long term illness scheme. (We have both public and private healthcare available)

Just because you never see the cost, doesn’t mean it costs “nothing”.

Re: Low carb diet leads to “clinical remission” in 3 cases of type 1 diabetes

#105

Post by JamesBarney »

eebynight wrote: post #102
JamesBarney wrote: post #91

Earlier quoted context omitted.

Just an addendum to people who aren't familiar with medical research. This is way outside of mainstream medical practice, and 95% of researchers in the field believe cholesterol matters, statins have saved more lives than any other drug, and they improve cognition in most cases.

You must not know too many people that have taken statins... Sure, on paper, the LDL number goes down and according to the numbers you have a lower risk of heart attack, but the one common thing I've notice is that everyone complains that they feel terrible. Things like dizziness, nausea, low energy/libido, etc... Let's not forget that it takes mainstream science time to catch up to new research. There is a lag in ex…

> That being said, lipidology is extremely complex but in the case of low carbohydrate diets the issue of having high LDL and HDL may not be as bad as mainstream medicine would make it out to be.

I'd 100% agree with this. But "your cholesterol sky rocketing a good sign" is not something the evidence currently shows.

> that everyone complains that they feel terrible. Things like dizziness, nausea, low energy/libido, etc...

Statins definitely have side effects, just on balance it leads to better cognitive outcomes instead of worse ones.

It's true that it takes time for mainstream science to catch up. But new preliminary research is new and preliminary and when it goes wrong it goes wrong more catastrophically than solid mainstream science.

Re: Low carb diet leads to “clinical remission” in 3 cases of type 1 diabetes

#106

Post by igotsideas »

You basically don’t have a pancreas with type 1. These people still had beta cell function, which most type 1s don’t have. It was 3 subjects and limited time. Large scale long term studies would be helpful.

Plus they got diagnosed is late 30s/early 40s. This sounds more like insulin dependent type 2. It would make sense that the diet could work in this case.

Re: Low carb diet leads to “clinical remission” in 3 cases of type 1 diabetes

#107

Post by narag »

firethief wrote: post #92
PKop wrote: post #67

Earlier quoted context omitted.

>this is so general that it’s not helpful I think digging into the minutiae of specific numbers is silly, when the better frame is to construct the right diet the comports w/ human evolution and lifestyle, energy, activity and go from there. Generally low carb (particularly avoiding high glycemic index carb, and sugars) preferring lower starch vegetables, while prioritizing animal fats, meat, fish. Keto / keto carniv…

Keto diets have most definitely not been around long enough for anyone's bodies to evolve to follow them. That takes many thousands of years.

The diet of primitive humans was more similar to keto than to current developed country diets and it was in place for hundreds of thousands of years. The first big change was from agricultural civilizations in neolithic, less than ten thousands year ago. Current diet is at most a hundred years old. And specifically the diet that is causing so many problems is only fifty years old.

Re: Low carb diet leads to “clinical remission” in 3 cases of type 1 diabetes

#108

Post by eebynight »

firethief wrote: post #92
PKop wrote: post #67

Earlier quoted context omitted.

>this is so general that it’s not helpful I think digging into the minutiae of specific numbers is silly, when the better frame is to construct the right diet the comports w/ human evolution and lifestyle, energy, activity and go from there. Generally low carb (particularly avoiding high glycemic index carb, and sugars) preferring lower starch vegetables, while prioritizing animal fats, meat, fish. Keto / keto carniv…

Keto diets have most definitely not been around long enough for anyone's bodies to evolve to follow them. That takes many thousands of years.

Why would our bodies need to evolve to follow them when the mechanisms are already built-in?

Our body already contains the necessary pathways, enzymes and processes to switchover to utilizing fat as fuel. We quite literally evolved to do this...

That being said, I think this adaption was more of an energy conservation mode for when food was scarce rather than our ancestors intentionally eating in a ketogenic compatible manner.

Re: Low carb diet leads to “clinical remission” in 3 cases of type 1 diabetes

#109

Post by messe »

wincy wrote: post #104
messe wrote: post #97

Earlier quoted context omitted.

It's a hell of a lot higher than most developed nations. Here in Ireland, as far as I'm aware, it's free thanks to the long term illness scheme. (We have both public and private healthcare available)

Just because you never see the cost, doesn’t mean it costs “nothing”.

Sure, but to someone who's on unemployment benefits. It's free. To someone who's earning a little bit more than that, it's free. To someone who is earning enough to pay tax, they're paying a tiny amount. To someone who's earning more than 30K€, they're paying a few grand in taxes (which covers other public services also). To someone who's earning 60k€ they're paying even more.

But the important thing is that the person who's earning fuck-all can still afford it, because it costs nothing to them.

Re: Low carb diet leads to “clinical remission” in 3 cases of type 1 diabetes

#110

Post by eebynight »

rantwasp wrote: post #82
KerryJones wrote: post #50

Earlier quoted context omitted.

LDL is correlated but not causative and it's been discovered that HDL is a much better indicator. Take a look at this book: https://www.amazon.com/Big-Fat-Surprise-Butter-Healthy/dp/14... It goes into it quite a bit more -- cholesterol is a _terrible_ indicator of overall health. This is well known in the Keto community.

when you use LDL, HDL and cholesterol interchangeably this tells me that you don’t know what you’re talking about. Cholesterol itself is part of the lipid membrane of every cell. It’s essential. When people say “high cholesterol” they usually talk about high cholesterol carrying lipo-proteins in the bloodstream. high ldl is definitely a risk factor for CHD

How do you explain what Dave Feldman refers to as the lipid triad which is common in people that are on a low carbohydrate diet?

In this case, there is not sufficient evidence that those who have elevated HDL, LDL and low triglycerides have higher rates of cardiovascular disease...

https://cholesterolcode.com/a-dialog-on-the-lipid-triad-with...

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