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Diluting blood plasma rejuvenates tissue, reverses aging in mice

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Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#91

Earlier quoted context omitted.

is there a way to supplement it, such as milk or egg whites?

https://en.wikipedia.org/wiki/Hypoalbuminemia If your albumin levels are low, then you probably have more serious problems than your albumin levels being low, so you'd want to treat the underlying condition.

Yeah - the person I knew who had it had cancer, and was dying of it. It is not common, and speaks of major organ failure.

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#92
post #57

Post-hoc "evolutionary just-so story" of the day: animals evolved under conditions of predation, where they'd tend to lose blood regularly, either in the process of fighting off/getting away from predators, or in the process of attacking prey with violent defenses. A species that goes years without losing any blood, is effectively operating its body in an evolutionary out-of-spec configuration. It might work , for a…

Here's a good-ish article on bloodletting in the modern age: https://www.artofmanliness.com/articles/the-potential-benefi...

TLDR: There are correlations that it reduces circulating iron, circulating cancer cells, arterial hardening, decrease insulin sensitivity, and it increased metabolism. Not a lot of super firm evidence though

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#93
post #57

Post-hoc "evolutionary just-so story" of the day: animals evolved under conditions of predation, where they'd tend to lose blood regularly, either in the process of fighting off/getting away from predators, or in the process of attacking prey with violent defenses. A species that goes years without losing any blood, is effectively operating its body in an evolutionary out-of-spec configuration. It might work , for a…

The way to test this is to follow all people that donate blood.

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#94

Scientifically interesting. A lot of people that have acquired the wisdom of experience would probably shudder at the thought of living 500 years, though.

But to no small extent because of people who have not yet acquired the wisdom of experience. It would be interesting to see the societal effects of a larger fraction of the population having grown up.

And one could always opt out...

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#96
post #57

Post-hoc "evolutionary just-so story" of the day: animals evolved under conditions of predation, where they'd tend to lose blood regularly, either in the process of fighting off/getting away from predators, or in the process of attacking prey with violent defenses. A species that goes years without losing any blood, is effectively operating its body in an evolutionary out-of-spec configuration. It might work , for a…

There is another than menstruating women group of people losing blood: blood donors.

If I remember correctly, it is beneficial for your health to donate blood if you have some predisposition for Fe accumulation (hemochromatosis in the severe form.

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#97

Earlier quoted context omitted.

This is getting flagged down as a dumb joke, but for those in the cheap seats, it's not entirely clear exactly how this differs. Presumably adding "adding albumin and water" is different than just "adding water". But why, exactly? And so on.

It differs because everything except saline and albumin is filtered out. The point is to show that some markers of aging are harmful byproducts in your blood, and filtering them out can have positive effects.

Actually, albumin seems to be filtered out as well and replaced. If I understand correctly, albumin is a transport protein, so it carries around a lot of stuff. When it gets replaced, it is replaced with a "blank" version.

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#98
post #57

Post-hoc "evolutionary just-so story" of the day: animals evolved under conditions of predation, where they'd tend to lose blood regularly, either in the process of fighting off/getting away from predators, or in the process of attacking prey with violent defenses. A species that goes years without losing any blood, is effectively operating its body in an evolutionary out-of-spec configuration. It might work , for a…

> A species that goes years without losing any blood, is effectively operating its body in an evolutionary out-of-spec configuration. It might work, for a while; but it wasn't heavily optimized for. I think your/the hypothesis fails...take certain species of jellyfish that are biologically immortal, they don’t have blood at all. Coincidentally they are considered top of the food chain, so another knock to the hypothe…

> they don't have blood at all

Then that would be an evolutionary in-spec configuration, since Cnidaria-phylum species have evolved under selection pressure for hundreds of millions of years in that "never losing blood, because it doesn't have any" configuration.

For a similar reason, you wouldn't expect most plants to be troubled/benefited by the loss of solutes (= sap); a maple tree should probably live about the same lifetime whether it's tapped or not, because maple trees evolved mostly without predation. But for plants that have evolved over eons entirely under conditions of predation (e.g. where they're a primary ecological water source, like cacti in the desert—observable by the fact that they possess defenses to predation), you would expect a difference in longevity between those that lose transported solutes to predation, vs. those who don't.

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#99
post #80
post #57

Post-hoc "evolutionary just-so story" of the day: animals evolved under conditions of predation, where they'd tend to lose blood regularly, either in the process of fighting off/getting away from predators, or in the process of attacking prey with violent defenses. A species that goes years without losing any blood, is effectively operating its body in an evolutionary out-of-spec configuration. It might work , for a…

A testable hypothesis for your idea: do women age slower than men.

Good luck getting rid of all the confounders involved in testing that hypothesis. Men and women are much more different than in that one sex may lose more blood throughout their lifetime.

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#100
post #57

Post-hoc "evolutionary just-so story" of the day: animals evolved under conditions of predation, where they'd tend to lose blood regularly, either in the process of fighting off/getting away from predators, or in the process of attacking prey with violent defenses. A species that goes years without losing any blood, is effectively operating its body in an evolutionary out-of-spec configuration. It might work , for a…

I don't know but since I was young it always seemed intuitive that blood-letting ought to have some good effects. If xyz bad things buildup (say, heavy metals) exist in the blood stream, and you remove a few % of your blood stream to make new blood, haven't you removed some xyz bad buildup?

That sounds more like an argument in favor of having kidneys than anything else...
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