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Diluting blood plasma rejuvenates tissue, reverses aging in mice

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Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#31
post #5

Basically, stay hydrated? :)

This is getting flagged down as a dumb joke, but for those in the cheap seats, it's not entirely clear exactly how this differs. Presumably adding "adding albumin and water" is different than just "adding water". But why, exactly? And so on.

It differs because everything except saline and albumin is filtered out. The point is to show that some markers of aging are harmful byproducts in your blood, and filtering them out can have positive effects.

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#32
post #21

Earlier quoted context omitted.

This is getting flagged down as a dumb joke, but for those in the cheap seats, it's not entirely clear exactly how this differs. Presumably adding "adding albumin and water" is different than just "adding water". But why, exactly? And so on.

If you’ve never encountered someone with low blood albumin, it is a very serious problem. You get terrible edema all over. Albumin helps you not retain the water in your cells, and instead to get the fluid back into your bloodstream for excretion.

is there a way to supplement it, such as milk or egg whites?

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#34

I just gave blood today. I have been trying to give blood as often as possible (once every eight weeks) to help keep cholesterol and iron low. Now, of course, I'm getting a free COVID-19 antibody test out of the deal. I'm wondering if this frequency of blood donations has a similar effect.

Aside from the altruistic aspect, I had extra motivation to give blood from an unfounded pet theory that the body isn't capable of removing all bad products that ends up in the bloodstream. Giving blood seemed like a safer way to purge some of these products than diy at-home phlebotomy. It's nice to finally have some research supporting this guess.

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#35
I think popular press of animal studies is mostly clickbait, especially aging studies.

The lifetimes of mice are so small compared to humans that you have to apply large scaling factors. An old mouse would be a very young human. How valid the scaling factors are is a different story.

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#36
post #27

So, blood-letting[1] works? [1] https://www.history.com/news/a-brief-history-of-bloodletting

Lovely anecdote:

A relative of mine has seasonal headaches that they experience, and they have told me that the way they relieve them is to go and donate blood.

Works every time, without a hitch.

I wouldn't be surprised if there is at least one study out there (or maybe even a wikipedia page) that attests to this phenomenon.

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#37
post #27

So, blood-letting[1] works? [1] https://www.history.com/news/a-brief-history-of-bloodletting

Lovely anecdote: A relative of mine has seasonal headaches that they experience, and they have told me that the way they relieve them is to go and donate blood. Works every time, without a hitch. I wouldn't be surprised if there is at least one study out there (or maybe even a wikipedia page) that attests to this phenomenon.

Same, my hematocrit gets high during seasonal allergies. Donating blood clears this up.

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#38

Earlier quoted context omitted.

From interview with the authors, why you should be a bit careful with just going ahead and trying this out "This is a somewhat invasive procedure where your whole blood goes through a machine and the cells are returned to you and the plasma is diluted. It is not completely benign, and you cannot just keep doing it every day. So, to know how long the effects last and to know it for each individual is an additional kno…

> do not go somewhere and get your blood replaced with saline I just did that this morning when I donated blood. They said they needed the plasma badly, so they took the red blood cells and the plasma, and returned a saline solution. So maybe you just need to donate blood/plasma often to stay young?

study shows that people, who donate a lot of blood, suffer no serious ill effects and may even live longer than less frequent donors.

https://sciencenordic.com/body-death-denmark/frequent-blood-...

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#39
There's a Spanish pharma company (Grifols) that has been experimenting for years with plasma replacement to slow down or stop Alzheimer's disease progression. The first results of the therapy called AMBAR (Alzheimer's disease Management by Albumin Replacement) seem to be a slow down of the progression of the disease by 71% in moderate cases:

"The CDR-Sb scale – which assesses memory, orientation, judgment, community affairs, home and hobbies, and personal care – showed a 71% reduction in clinical decline with respect to placebo in patients treated as a whole and in all three clinical trial treatment arms analyzed separately."

https://www.webwire.com/ViewPressRel.asp?aId=251270

Which is interesting because it seems they might have stumbled on a side effect of something bigger... And it could be possible to check the participants to the trial for other effects as well.

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