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Diluting blood plasma rejuvenates tissue, reverses aging in mice

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11–20 of 108 posts

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#11

Interview with the authors about the results: https://www.lifespan.io/news/diluting-blood-plasma-rejuvenat... An interesting blog post about the same paper: https://joshmitteldorf.scienceblog.com/2020/06/08/out-with-t...

Thank you for sharing Josh Mitteldorf's blog on this paper. I think that he has some useful ideas on how to interpret this in light of Harold Katcher's work.

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#12
post #3

Seems like the conspiracy theories that the rich and global elite harvest the blood of the young and innocent to rejuvenate them isn't as false as we once thought... /s Sometimes I wish we had a medical system where whoever wanted to be a test patient for whatever reason could sign on the dotted line once advised of the potential downsides (up to and including death assumedly) so we could advance medical science fast…

The point of this paper is no harvesting needed.

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#13
post #3

Seems like the conspiracy theories that the rich and global elite harvest the blood of the young and innocent to rejuvenate them isn't as false as we once thought... /s Sometimes I wish we had a medical system where whoever wanted to be a test patient for whatever reason could sign on the dotted line once advised of the potential downsides (up to and including death assumedly) so we could advance medical science fast…

From interview with the authors, why you should be a bit careful with just going ahead and trying this out

"This is a somewhat invasive procedure where your whole blood goes through a machine and the cells are returned to you and the plasma is diluted. It is not completely benign, and you cannot just keep doing it every day. So, to know how long the effects last and to know it for each individual is an additional know-how part that we found out from a couple of years of research and are studying further. I’m sure there will be competition, but I just want to warn everybody, do not go somewhere and get your blood replaced with saline. Wait until there are reputable clinical trials and people know a little bit more."

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#15
post #3

Seems like the conspiracy theories that the rich and global elite harvest the blood of the young and innocent to rejuvenate them isn't as false as we once thought... /s Sometimes I wish we had a medical system where whoever wanted to be a test patient for whatever reason could sign on the dotted line once advised of the potential downsides (up to and including death assumedly) so we could advance medical science fast…

Wouldn't call it a conspiracy, the show Silicon Valley was mocking those who do it years ago.

https://www.youtube.com/watch?v=hBA0AH-LSbo

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#16
post #3

Seems like the conspiracy theories that the rich and global elite harvest the blood of the young and innocent to rejuvenate them isn't as false as we once thought... /s Sometimes I wish we had a medical system where whoever wanted to be a test patient for whatever reason could sign on the dotted line once advised of the potential downsides (up to and including death assumedly) so we could advance medical science fast…

From interview with the authors, why you should be a bit careful with just going ahead and trying this out "This is a somewhat invasive procedure where your whole blood goes through a machine and the cells are returned to you and the plasma is diluted. It is not completely benign, and you cannot just keep doing it every day. So, to know how long the effects last and to know it for each individual is an additional kno…

> do not go somewhere and get your blood replaced with saline

I just did that this morning when I donated blood. They said they needed the plasma badly, so they took the red blood cells and the plasma, and returned a saline solution.

So maybe you just need to donate blood/plasma often to stay young?

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#17
I just gave blood today. I have been trying to give blood as often as possible (once every eight weeks) to help keep cholesterol and iron low. Now, of course, I'm getting a free COVID-19 antibody test out of the deal. I'm wondering if this frequency of blood donations has a similar effect.

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#18
post #5

Basically, stay hydrated? :)

This is getting flagged down as a dumb joke, but for those in the cheap seats, it's not entirely clear exactly how this differs. Presumably adding "adding albumin and water" is different than just "adding water". But why, exactly? And so on.

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#20
The implication is not that young blood has specific positive properties, but that old blood has specific negative properties. Simply removing some of the "bad old blood" is already enough to measurably improve biomarkers. Identifying the bad stuff may go a long way to counteracting it in a more targeted way.
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