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New Abbott SARS-CoV-2 antibody test has 99.90% specificity and 100% sensitivity

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Re: New Abbott SARS-CoV-2 antibody test has 99.90% specificity and 100% sensitivity

#211

Earlier quoted context omitted.

"Weird cold" in February checking in. I did not have any temperature variations or fevers, but I got struck with a fatigue like no other. For the first time since I was 3 years old, I took afternoon naps three days in a row because I was just completely wiped out. It's rare for me to take a nap at all (happens maybe once a year)! It took two weeks to get out of this fatigued state. My other symptoms were "chills-like…

> I still think there's a possibility this virus was already in the US before 2020. Yeah, I don’t understand why people are so against the idea of it being in the U.S. before 2020. There’s no possible way we can trace every American who may have traveled within the China region or interacted with another person who was in that region around the start of COVID spreading. Just because there were no official cases of CO…

I think the main evidence against it being here siginifgantly earlier is that we see how it spread when it was definitely here, so why wouldn't we have seen hot spots like Atlanta and New York earlier then?

Re: New Abbott SARS-CoV-2 antibody test has 99.90% specificity and 100% sensitivity

#212
post #155

Slightly misleading headline. The test is not new, it's been launched since April and has already shipped 10M tests. According to https://abbott.mediaroom.com/2020-05-08-Research-from-Univer...

It's new.This is the second antibody test Abbott is launching. Disclosure: I work for Abbott.

Do you know which of the two is being used by commercial labs like Quest now?

Re: New Abbott SARS-CoV-2 antibody test has 99.90% specificity and 100% sensitivity

#213

Earlier quoted context omitted.

Good anecdote. I also had a "weird cold" in February with symptoms that are unusual for me but typical of COVID-19, and have been waiting to get the antibody test. I kind of expect it to turn out the same way. (Otherwise, I would really like to figure out what the "weird cold" that everyone had in February was. Because it sure was weird, and everyone I know had it.)

"Weird cold" in February checking in. I did not have any temperature variations or fevers, but I got struck with a fatigue like no other. For the first time since I was 3 years old, I took afternoon naps three days in a row because I was just completely wiped out. It's rare for me to take a nap at all (happens maybe once a year)! It took two weeks to get out of this fatigued state. My other symptoms were "chills-like…

Mine was in late March. I guess the quarantine efforts paid off!

Sure would like to try that antibody test.

Re: New Abbott SARS-CoV-2 antibody test has 99.90% specificity and 100% sensitivity

#214

Earlier quoted context omitted.

> I still think there's a possibility this virus was already in the US before 2020. Yeah, I don’t understand why people are so against the idea of it being in the U.S. before 2020. There’s no possible way we can trace every American who may have traveled within the China region or interacted with another person who was in that region around the start of COVID spreading. Just because there were no official cases of CO…

I think the main evidence against it being here siginifgantly earlier is that we see how it spread when it was definitely here, so why wouldn't we have seen hot spots like Atlanta and New York earlier then?

Perhaps it mutated at some point to become more infectious, and that mutation happened in Asia.

Re: New Abbott SARS-CoV-2 antibody test has 99.90% specificity and 100% sensitivity

#215

Earlier quoted context omitted.

I keep reading people asserting this, and I assume it's because we believe that a virus that becomes less lethal would have an evolutionary advantage. But, wouldn't lengthening the incubation period also be a successful evolutionary strategy regardless of lethality? It seems to me that there are many possible strategies that a mutating virus might gain an advantage and we shouldn't just assume that the only one that…

'Tend to' doesn't mean some conscious, directed effort. On large enough scale, this is generally the more probable direction, and that's about it. Its truly random by nature. It can very well go the other way as with 1918 'spanish' flu. Or it can change in ways that won't affect overall mortality much.

It's interesting you should mention the 1918 flu. That one had two waves, the first one less lethal... Evolution is random, add you say, but that's not quite what happened.

It was in the middle of world war 1. Soldiers were infected, and the ones that became the most ill were sent home to recuperate, or die. Either way they spread the virus better than the ones who weren't as ill, and who stayed in the field.

So the usual evolutionary pressure was upside down here.

Re: New Abbott SARS-CoV-2 antibody test has 99.90% specificity and 100% sensitivity

#216

I took this antibody test through LabCorp on Friday and tested positive. I have been in strict (see: paranoid) isolation with one other person since March 7 and haven't felt sick or anything close to it since then. I did have what I thought was a strange flu/cold early February with a sore throat, post-nasal drip, wildly varying body temperature, and lower back pains. In hindsight those are COVID-19 symptoms. the per…

Thanks. I signed up for the test as well.

Re: New Abbott SARS-CoV-2 antibody test has 99.90% specificity and 100% sensitivity

#217

Earlier quoted context omitted.

> I still think there's a possibility this virus was already in the US before 2020. Yeah, I don’t understand why people are so against the idea of it being in the U.S. before 2020. There’s no possible way we can trace every American who may have traveled within the China region or interacted with another person who was in that region around the start of COVID spreading. Just because there were no official cases of CO…

I think the main evidence against it being here siginifgantly earlier is that we see how it spread when it was definitely here, so why wouldn't we have seen hot spots like Atlanta and New York earlier then?

I understand that line of thinking but that would imply the prevalence rate of COVID was in complete parallel with the incidence rate. The former is what we do not know and that's clear when we've had patients labs reran from 2019 and found it was positive for COVID. Government data from China says the first case can be traced back to 17 November 2019 and even then they're unsure if that was patient zero[0]

How many American's were in Asia, China, or surrounding areas between October and December of 2019? How many of them were possibly infected? Nobody knows because there was no plan put in place with regard to travel to mainland China until the end of January 2020; even then since 1 January 2020, there were 430,000 people who traveled from China to the U.S.[1]

0: https://www.scmp.com/news/china/society/article/3074991/coro...

1: https://www.nytimes.com/2020/04/04/us/coronavirus-china-trav...

Re: New Abbott SARS-CoV-2 antibody test has 99.90% specificity and 100% sensitivity

#218

I took this antibody test through LabCorp on Friday and tested positive. I have been in strict (see: paranoid) isolation with one other person since March 7 and haven't felt sick or anything close to it since then. I did have what I thought was a strange flu/cold early February with a sore throat, post-nasal drip, wildly varying body temperature, and lower back pains. In hindsight those are COVID-19 symptoms. the per…

The fact that the US government isn't buying up the full testing capacity of the private sector... Jesus fucking christ

Re: New Abbott SARS-CoV-2 antibody test has 99.90% specificity and 100% sensitivity

#219

Earlier quoted context omitted.

Your FB feed results don't seem impossible. First CV-19 death in CA was Feb 6 [1]. That's presumably at least a couple of weeks after infection. [1] https://www.nytimes.com/2020/04/22/us/coronavirus-first-unit...

The question isn't whether they're possible, it's whether the antibody tests are reliable that far from the actual incidence of C19.

Don’t you mean sensitivity dropping off? The way it’s phrased sounds like someone is more likely to get a false positive as time passes after... no infection happened?

Re: New Abbott SARS-CoV-2 antibody test has 99.90% specificity and 100% sensitivity

#220
>Alternative index value thresholds for positivity resulted in 100% sensitivity and 100% specificity in this cohort.

This would be true of a coin flip, wouldn't it? "Head means positive, tails means not negative" would be 100% sensitivity and "Tails means negative, heads means you're not positive" would be 100% specificity. So those would be the "alternative index value thresholds."

https://en.wikipedia.org/wiki/Sensitivity_and_specificity

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