How does the coronavirus kill?

Post by rurban » Mon, Apr 20, 2020, 7:34 PM UTC

maxerickson wrote: post #13

ramraj07 wrote: post #7

Only one thing is clear about our immune system: it's extremely complex and even after a century of prodding it, we still don't know it well enough to prod it in targeted ways and know what to expect. Especially, suppressing the immune system is always dicey, since its not just one variable you tune up or down. However, there _is_ a magic bullet of sorts out there, Intravenous immunoglobulin (IVIG). IVIG is just conc…

Isn't the original use of IGIV as a supportive therapy for people not producing antibodies (for whichever reason)? In the case of COVID-19, plasma therapy (which transfers antibodies from a survivor to an infected) is one of the more promising short term mitigations.

Post by pas » Tue, Apr 21, 2020, 3:48 PM UTC

ramraj07 wrote: post #23

joezydeco wrote: post #20

Cameron Kyle-Sidell is a New York ICU doctor that has been trying to help figure out why treatments aren't working as expected. His videos are highly technical but interesting to watch. Kyle-Sidell believes it's a diffusion hypoxemia problem, leading to pulmonary edema (which is something you see in high-altitude sickness) https://www.youtube.com/watch?v=NmRlvX3VrAQ&feature=youtu.be https://twitter.com/cameronks/stat…

The hypothesis suggested in the science article sounds more plausible - these patients are truly oxygen deprived, but potentially because of the vascular Nature of the infection, the typical gasping response is not initiated