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Psilocybin Produced in Yeast

phys.org

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Re: Psilocybin Produced in Yeast

#31

Post by hatsunearu »

elil17 wrote: post #4
msla wrote: post #2

Realistically, I know this will be used to make pills. But the first thing I thought when I saw the headline was, "Wow. That's some interesting beer."

I mean it sounds like if you could get your hands on this yeast you could actually make psychedelic beer (or bread).

I think the method uses some special enzymes that can only be really be used with yeast. So yeast is just a supporting role in the operation and the enzyme is the star.

They say they tried to get E. Coli to operate the enzyme (E. Coli is used often to make all kinds of drugs, like insulin) but it didn't work and got yeast to work with it.

Re: Psilocybin Produced in Yeast

#32

Post by samatman »

taneq wrote: post #18
tdy721 wrote: post #12

Earlier quoted context omitted.

It’s not hard or expensive to turn brown rice flour and vermiculite into mushrooms. The bit about expensive to create a pharmaceutical compound growing from a mushroom is just silly. Extraction can’t be that expensive.

> Extraction can’t be that expensive. From the article, apparently yes it can: "It's unfeasible and way too expensive to extract psilocybin from magic mushrooms"

It does say that.

It's wrong, what it says, but it definitely says it.

Re: Psilocybin Produced in Yeast

#33

Post by TomMarius »

tdy721 wrote: post #14
arpa wrote: post #10

Earlier quoted context omitted.

Hey, drug on wars still exists in the world. You can get excessive jail time just for having some (regardless of quantity) marijuana on you - and that is in "western" country. It was not so long ago that "marijuana had no possible medical application" and was scheduled as a class A drug in UK (and I think, still is). There is a lot of stigma, and decades of bad science, propaganda, and manufactured hatred run deep. R…

You can go to jail for alcohol too. Just depends where you are.

Which western country is that? AFAIK even most islamist states allow alcohol for non-muslims.

Re: Psilocybin Produced in Yeast

#34

Post by globular-toast »

robin_reala wrote: post #11
arpa wrote: post #10

Earlier quoted context omitted.

Hey, drug on wars still exists in the world. You can get excessive jail time just for having some (regardless of quantity) marijuana on you - and that is in "western" country. It was not so long ago that "marijuana had no possible medical application" and was scheduled as a class A drug in UK (and I think, still is). There is a lot of stigma, and decades of bad science, propaganda, and manufactured hatred run deep. R…

Cannabis was downgraded from class A to a class C drug in the UK in 2004, but was upgraded to class B five years later. https://en.wikipedia.org/wiki/Drugs_controlled_by_the_UK_Mis...

It was downgraded from class B. It was never class A. The next government returned it to class B because "drugs bad".

Re: Psilocybin Produced in Yeast

#35

Post by mirimir »

mikeg8 wrote: post #5

> "It's unfeasible and way too expensive to extract psilocybin from magic mushrooms and the best chemical synthesis methods require expensive and difficult to source starting substrates...” This is one of those situations where I feel like we (humans) are approaching it all wrong. Why over complicate it by trying to “extract” the psilocybin instead of treating it like marijuana and growing the mushrooms in highly con…

Yes, I'd rather just eat the mushrooms. We used to grow them on autoclaved rice, in mason jars. Also, it's not at all obvious that psilocybin is the only active compound. And conversely, I wouldn't want to experiment with analogs that don't predominate in mushrooms.

Re: Psilocybin Produced in Yeast

#36

Post by mirimir »

karlicoss wrote: post #16
mikeg8 wrote: post #5

> "It's unfeasible and way too expensive to extract psilocybin from magic mushrooms and the best chemical synthesis methods require expensive and difficult to source starting substrates...” This is one of those situations where I feel like we (humans) are approaching it all wrong. Why over complicate it by trying to “extract” the psilocybin instead of treating it like marijuana and growing the mushrooms in highly con…

As far as I understand it's too inconsistent, i.e. very unevenly distributed within one fruiting body. Not sure if that's the reason, but: if you ever bought mushrooms/truffles in the Netherlands, there is no psylocibin content on the box. And if you try googling, the estimates vary pretty wildly (although it's possible that it's just a lack or proper research) Also not everyone enjoys the taste of mushrooms or truff…

Freshly picked Psilocybe are tasty. At least, those grown on rice. Not so much when grown on cow patties, however ;)

Re: Psilocybin Produced in Yeast

#37

Post by plurinshael »

asdff wrote: post #26
mikeg8 wrote: post #5

> "It's unfeasible and way too expensive to extract psilocybin from magic mushrooms and the best chemical synthesis methods require expensive and difficult to source starting substrates...” This is one of those situations where I feel like we (humans) are approaching it all wrong. Why over complicate it by trying to “extract” the psilocybin instead of treating it like marijuana and growing the mushrooms in highly con…

Growing it in yeast would be great if you are trying to get a consistent quantity of the drug. You could do vats at a time all genetically identical and producing the same yield batch over batch, and can scale up and down your operation for as much as you have vats and yeast food. This is something you want if you are going to press this into pills at a certain dose and give to people for psychiatric disorders, not f…

People with psychiatric disorders need spiritual journeys. Spiritual journeys heal and cleanse the mind, heal and cleanse the soul. Do not try to strip that away.

The commodification of medicine troubles me--I prefer the perspective of sacred medicine. It goes roughly definitionally / tautologically: if something heals you, is it not sacred? And likewise, if something is sacred, it heals you. By definition. The idea of medicine as a mechanism has really lost something intimate and special, compared to the idea of medicine as divine.

Re: Psilocybin Produced in Yeast

#38

Post by mirimir »

Alex3917 wrote: post #25
mikeg8 wrote: post #5

> "It's unfeasible and way too expensive to extract psilocybin from magic mushrooms and the best chemical synthesis methods require expensive and difficult to source starting substrates...” This is one of those situations where I feel like we (humans) are approaching it all wrong. Why over complicate it by trying to “extract” the psilocybin instead of treating it like marijuana and growing the mushrooms in highly con…

> There is no reason That psilocybin shouldn’t be administered in its most common form, as it has been for thousands of years They’re using very large doses in therapy, and there are a lot of unpleasant things that are going to happen already even at the minimum effective dose.

I doubt that they're "using very large doses in therapy". Compared to serious recreational users, that is. And in my experience, few if any "unpleasant things" occur with Psilocybe. What things were you thinking of?

Re: Psilocybin Produced in Yeast

#39

Post by andrew_xor_andy »

> the best chemical synthesis methods require expensive and difficult to source starting substrates

This type of thing always amazes me about nature -- obviously all the ingredients necessary exist in the soil the mushroom is grown in!

Yet the best we can do to mimic nature is get some hard-to-acquire substrates. It's so interesting how, given enough time, the universe can produce a self-replicating organism that can do something with basic building blocks that we can't do with current technology...

(okay, maybe this is a bit romantic, but it's still fun to think about)

Re: Psilocybin Produced in Yeast

#40

Post by jokowueu »

mikeg8 wrote: post #5

> "It's unfeasible and way too expensive to extract psilocybin from magic mushrooms and the best chemical synthesis methods require expensive and difficult to source starting substrates...” This is one of those situations where I feel like we (humans) are approaching it all wrong. Why over complicate it by trying to “extract” the psilocybin instead of treating it like marijuana and growing the mushrooms in highly con…

How about we don't do that either . Psilocybin doesn't have any effect on the human body afaik before breaking down to psilocin . 4-aco-dmt is easy to make and readily breaks down to psilocin .

Why are trials and research concentrating on this prodrug like it's necessary is beyond my understanding . It's a waste of money and time

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