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Bosch develops rapid test for Covid-19

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Re: Bosch develops rapid test for Covid-19

#131

Post by noir_lord »

rubidium wrote: post #104
rurban wrote: post #98

This is not rapid, only 10 tests/day, whilst the current overly slow sequencers can do 200/day. The accuracy of 5% is also worse than other faster sequencers of 3%. And compare that to modern ThermalFischer parallel PCR sequencers, which operate in realtime, 25 tests in parallel, for 2.500€. That's a factor of 1000. With 10 modern sequencers per city you could test 10.000 per day, eg with drive-in. https://www.thermo…

Agreed. Also the Cepheid one is faster (45 minute for point-of-care results) and has FDA approval ... not sure other advantages/disadvantages of each system though (instrument and reagent cost, # deployed units, etc). https://www.cepheid.com/coronavirus That said, it’s great to see all the companies that are putting real effort into this. This is their time to serve. My own employer has assembled a task force for rep…

I don't work in an area where my skills can contribute but I'm in the process of finding out if I can sort insurance out to go out and do medication deliveries on motorcycle for local pharmacises, with the lockdown and the number of vulnerable people (including my mother and best friend) who can't leave their houses there is >1.5m people who can't leave at all for health reasons most of whom require prescription medication monthly.

At the moment I feel so incredibly fucking useless lurking at home playing video games.

Re: Bosch develops rapid test for Covid-19

#132

Post by wenc »

rurban wrote: post #98

This is not rapid, only 10 tests/day, whilst the current overly slow sequencers can do 200/day. The accuracy of 5% is also worse than other faster sequencers of 3%. And compare that to modern ThermalFischer parallel PCR sequencers, which operate in realtime, 25 tests in parallel, for 2.500€. That's a factor of 1000. With 10 modern sequencers per city you could test 10.000 per day, eg with drive-in. https://www.thermo…

Tell us more. Another comment has a link to a news article that says this Bosch machine costs 15.000€ with cartridges costing 50-100€. The Bosch machine has a faster response (2.5hr), but lower overall throughput.

How much does the ThermoFischer sequencer cost? Is it affordable enough that every hospital just buys one and becomes a regional testing lab? How much specialized training does it need? (in every major city there are tons of biology and biology-adjacent majors who've done lab work but discovered there's no living to be made in bio so have switched to other fields).

Re: Bosch develops rapid test for Covid-19

#133

Post by zitterbewegung »

noir_lord wrote: post #131
rubidium wrote: post #104

Earlier quoted context omitted.

Agreed. Also the Cepheid one is faster (45 minute for point-of-care results) and has FDA approval ... not sure other advantages/disadvantages of each system though (instrument and reagent cost, # deployed units, etc). https://www.cepheid.com/coronavirus That said, it’s great to see all the companies that are putting real effort into this. This is their time to serve. My own employer has assembled a task force for rep…

I don't work in an area where my skills can contribute but I'm in the process of finding out if I can sort insurance out to go out and do medication deliveries on motorcycle for local pharmacises, with the lockdown and the number of vulnerable people (including my mother and best friend) who can't leave their houses there is >1.5m people who can't leave at all for health reasons most of whom require prescription medi…

Every day you don't fill a hospital bed can save countless lives. From the doctors who would have to diagnose and treat you to the people that you would infect when you don't realize you have the virus.

Sometimes being a hero is boring.

Re: Bosch develops rapid test for Covid-19

#134

Post by endymi0n »

tomcooks wrote: post #125
rsynnott wrote: post #103

Earlier quoted context omitted.

This is low throughput but high speed; there's a use-case for that.

Isn't that the same thing?

He means low throughput and low latency, both of which are related to a concept of speed, but not the same.

> Never underestimate the bandwidth of a station wagon full of tapes hurtling down the highway.

— Andrew S. Tanenbaum

Re: Bosch develops rapid test for Covid-19

#135

Post by fhars »

tomcooks wrote: post #125
rsynnott wrote: post #103

Earlier quoted context omitted.

This is low throughput but high speed; there's a use-case for that.

Isn't that the same thing?

No, this is faster than e.g. the Roche tests mentioned here last week, it will give you the first test result after two and a half hours, while the Roche one will take three and a half hours to give you the first result. So it is faster.

But it will give you the second test result after five hours, while the Roche machine will give you the second result after three and a half hours, too. As well as the third, the fourth, and the fifth. Oh, and the onehundredandninetysecond one, too. In the 24 hours the Bosch machine produces ten results, the Roche one will produce more than fourthousand results.

Re: Bosch develops rapid test for Covid-19

#136

Post by arrrg »

rsynnott wrote: post #103
rurban wrote: post #98

This is not rapid, only 10 tests/day, whilst the current overly slow sequencers can do 200/day. The accuracy of 5% is also worse than other faster sequencers of 3%. And compare that to modern ThermalFischer parallel PCR sequencers, which operate in realtime, 25 tests in parallel, for 2.500€. That's a factor of 1000. With 10 modern sequencers per city you could test 10.000 per day, eg with drive-in. https://www.thermo…

This is low throughput but high speed; there's a use-case for that.

I heard that this is about testing in the periphery? MDs could put it in their offices and test their employees daily, for example. That’s one possible use case.

Re: Bosch develops rapid test for Covid-19

#137

Post by mikeiz404 »

>In various laboratory tests with SARS-CoV-2, the Bosch test delivered results with an accuracy of over 95 percent.

Curious what the false negative rate is.

>[The device] can perform up to ten tests in the space of 24 hours

>[Testing] can be performed directly at the point of care. This eliminates the need to transport samples, which takes up valuable time. ... With the tests currently in use, patients must usually wait one to two days for a result

>... even medical personnel who have not been specially trained on it can reliably perform the test.

>... it allows a single sample to be tested not just for COVID-19 but also for nine other respiratory diseases, including influenza A and B, simultaneously

Re: Bosch develops rapid test for Covid-19

#138

Post by fhars »

zulln wrote: post #87
de_watcher wrote: post #45

Earlier quoted context omitted.

Better (or worse) marketing: "a test takes almost 2.5 hours".

Is that true, or is it running multiple tests partly simultaneously?

Yes, and no. In runs nine tests in parallel (like Covid-19, influenza-A, influenza-B etc), but all on the same sample.

Re: Bosch develops rapid test for Covid-19

#139

Post by oldgradstudent »

acqq wrote: post #102
oldgradstudent wrote: post #83

Earlier quoted context omitted.

Not necessarily. Hospitals in an epidemic are major spreaders of the infection. If false positive results lead to patients being put together with real carriers, they will soon be infected. From a recent report[1] from Italy: > For example, we are learning that hospitals might be the main Covid-19 carriers, as they are rapidly populated by infected patients, facilitating transmission to uninfected patients. Patients…

> some of the major causes of the large death toll... Wrong. The major cause is that the number of people getting sick at once was much higher than the infrastructure can handle. That's what other governments saw and now try to avoid with the lockdowns. This was made 10 days ago by the Italian biotech Association it's the number of new cases and deaths per week (red), compared with the number of cases per week at the…

Thank you so much for explaining exponential growth to me.

> Nobody has thousandfold more hospital beds and doctors ready, even less a million times more, which is the two month's growth.

And in a few additional months, we will need more ICU beds than the number of atoms in the universe.

Infection rates are already significant, there just aren't enough people to sustain two months' growth.

Re: Bosch develops rapid test for Covid-19

#140

Post by usrusr »

Vesther wrote: post #99
usrusr wrote: post #20

Earlier quoted context omitted.

True. This is seems to be on one of the extreme ends of latency versus throughput optimization and its niche in the big picture of Covid-19 will be very small. But it appears to be a new test cartridge for an already deployed machine, so it makes sense to have it anyways. I don't know who the typical customer of an on-site lab in a box like that is, but I guess that as last part of the market will be defined by remot…

Speaking of things fluffy, for what I assume to be a cutting-edge medical device the promo video on that page is.. interesting. https://www.youtube.com/watch?v=jgW2pYmzcco

Oh, impressive demonstration of why stuff is expensive, and which b-arker jobs will likely take the biggest hit from post pandemic down-to-earth-ness.
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