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Bosch develops rapid test for Covid-19

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Re: Bosch develops rapid test for Covid-19

#91

Post by waterishail »

dx034 wrote: post #51
gpderetta wrote: post #15

Earlier quoted context omitted.

Don't current testing machines have much, much higher throughput? Like in the thousands of tests per day? It seems the advantage of this new device is latency. Of course if they are cheap enough and easy to use that you can buy thousands of them and distribute to all hospitals then might also increase total throughput.

The idea is to not have a lab with a huge machine testing several thousand samples a day, but to have these devices spread out throughout the hospital and doctor's offices to test closer to the patient. A device will also be much cheaper than the fully automated devices in labs. If it works and they can provide enough devices, this could be great. Logistics (getting samples and material to labs and handling them ther…

Also it can do multiple tests so it makes it easier to distinguish exactly what you have.

Re: Bosch develops rapid test for Covid-19

#92

Post by incompatible »

Various groups are also using the LAMP method (Loop-mediated isothermal amplification) which can apparently give results in 30 minutes or so without expensive thermal cycling equipment.

https://duckduckgo.com/?q=Loop-mediated+isothermal+amplifica...

Bonus article with biohackers in Sydney: https://www.abc.net.au/news/2020-03-25/amateur-scientist-mak...

Re: Bosch develops rapid test for Covid-19

#93

Post by nabla9 »

1000 tests per day sounds like what typical hospital needs.

I wonder how much 100 Vivalytic devices cost and how much those cartridges cost.

Can they mix multiple samples into one test? If you take sample from 10 people, mix them to find that nobody is infected, it increases testing capability 10X.

Re: Bosch develops rapid test for Covid-19

#94

Post by gmueckl »

So the test depends on single use cartridges. How many of those can be manufactured?

The testing devices themselves seem to be around 15.000 Euros. So you'd have to have a very good reason to buy one - a reason that isn't throughput.

Re: Bosch develops rapid test for Covid-19

#96

Post by mehrdadn »

fit2rule wrote: post #90
mehrdadn wrote: post #82

Earlier quoted context omitted.

> Remember, COVID-19 is a global phenomenon, its not just relegated to the Anglo-sphere. Bosch, being a German company, is probably a bit sensitive to the accuracy of translations that will be needed to market this thing effectively around the world .. ;) ...what? I was only trying to help the parent find a way to remember which one is sensitivity and which one is specificity...

Yes, and you perfectly demonstrated the confusion possible by selecting the wrong terms. Sure, 'specificity' and 'sensitivity' are scientific terms - but for marketing material, can be confused with emotional responses. Thus, I believe Bosch chose 'accuracy', since this translates into other languages more effectively.

...marketing material? To the non-English world? I was literally just explaining a potentially helpful thought process to an English-speaking HN visitor dev who lists his(?) public key on his profile... not trying to produce marketing material for a French waiter or something. Are you sure you're not the one confused here rather than him?

Re: Bosch develops rapid test for Covid-19

#97

Post by TrickyRick »

shultays wrote: post #80

Up to 1,000 (in smaller font) tests per day on just 100 devices I guess 10 test per day per device is not as cool

If the tests take 2.5 hours and given that there is no parallellism it's pretty basic maths to figure out that 1 device can do about 10 tests per day.

Re: Bosch develops rapid test for Covid-19

#98

Post by rurban »

This is not rapid, only 10 tests/day, whilst the current overly slow sequencers can do 200/day. The accuracy of 5% is also worse than other faster sequencers of 3%.

And compare that to modern ThermalFischer parallel PCR sequencers, which operate in realtime, 25 tests in parallel, for 2.500€. That's a factor of 1000. With 10 modern sequencers per city you could test 10.000 per day, eg with drive-in.

https://www.thermofisher.com/de/de/home/clinical/clinical-tr...

Re: Bosch develops rapid test for Covid-19

#99

Post by Vesther »

usrusr wrote: post #20
ThePhysicist wrote: post #10

Sounds really impressive, but writing "1,000 tests per day with just 100 devivces" is really marketing BS I think. They should've just written "10 tests per day per device".

True. This is seems to be on one of the extreme ends of latency versus throughput optimization and its niche in the big picture of Covid-19 will be very small. But it appears to be a new test cartridge for an already deployed machine, so it makes sense to have it anyways. I don't know who the typical customer of an on-site lab in a box like that is, but I guess that as last part of the market will be defined by remot…

Speaking of things fluffy, for what I assume to be a cutting-edge medical device the promo video on that page is.. interesting.

https://www.youtube.com/watch?v=jgW2pYmzcco

Re: Bosch develops rapid test for Covid-19

#100

Post by dmix »

incompatible wrote: post #92

Various groups are also using the LAMP method (Loop-mediated isothermal amplification) which can apparently give results in 30 minutes or so without expensive thermal cycling equipment. https://duckduckgo.com/?q=Loop-mediated+isothermal+amplifica... Bonus article with biohackers in Sydney: https://www.abc.net.au/news/2020-03-25/amateur-scientist-mak...

This one claims 30 minutes for results for the standard product being repurposed by Bosch here as well.
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