Yes, but perhaps not in the way that you might think.
There were a number of structural factors that led to the great depression: gold standard currency and restrictive monetary policy at the Fed, overly restrictive tariff laws, simultaneous drought that destroyed a lot of farmland, rampant financial fraud, lack of deposit insurance at banks causing numerous bank runs and failures.
Basically all of the above is different now. The modern Fed is organized around preventing the monetary mistakes made during the depression. We are on purely fiat currency now, not the volatile gold standard. Food security is hugely increased, and restrictive tariffs have not impacted the ag industry of Canada and Mexico, which are key supports of the US's food supply chain. We have the FDIC for deposit insurance and increased post-Great Recession capital controls on systemically important financial institutions (SIFIs).
We have also learned from the Roosevelt interventions of the 1930's that it requires both a strong monetary and fiscal policy to address a systemic shock to the economy. So it might take some time for stimulus to arrive, but it should be incoming.
Finally, we have the internet. Not to oversell it, but it's a significant asset that can ensure a degree of continuity of supplies, services and employment in an event such as this. Yes - it's not perfect and many necessary jobs can not be done over the internet. But it's better than the alternative.
So, my feeling is that we are heading into the most significant non-wartime economic event since the great depression, but if cards are played properly we should be able to mitigate the terrible effects to a much better degree than was possible in the 1930's.