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Chloroquine has shown apparent efficacy in treatment of Covid-19

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Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#261

Post by vinay427 »

blaser-waffle wrote: post #237
codebolt wrote: post #143

Earlier quoted context omitted.

I have in-laws in Nigeria. We just tipped them off a couple of days ago that now might be a good time to buy some Chloroquine and keep at the house, in case the situation gets worse. This is a commonly known medicine down there, that you can get from pharmacies without prescription. But based on what we're seeing so far, it seems plausible that this virus prefers cooler northern climates. So hopefully it will turn ou…

> But based on what we're seeing so far, it seems plausible that this virus prefers cooler northern climates. So hopefully it will turn out to be an unnecessary precaution. Wuhan has temps around 50F-75F (~15C-22C). Certainty not hot, but not a cooler climate given how it's still winter in this hemisphere. Italy and Spain aren't known for being especially cold either, mountainous areas notwithstanding.

All of these locations are still cooler northern climates. I agree that they're not exactly cold.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#262

Post by WilsonPaige »

nl wrote: post #16
WilsonPaige wrote: post #12

Earlier quoted context omitted.

Heard of Google, bro? It's settled fact that the covid-19 pneumonia is a result of a "cytochine storm". Always like to lead off with a lancet article, to lance the boil: https://www.thelancet.com/journals/lancet/article/PIIS0140-6... https://link.springer.com/article/10.1007/s00134-020-05991-x https://www.cusabio.com/COVID-19-Cytokine-Storm https://lab-a-porter.com/2020/02/wuhan-coronavirus-and-cytok... The age-bande…

It's settled fact that the covid-19 pneumonia is a result of a "cytochine storm". This just isn't true. It maybe true for a subset of patients in some circumstances. To quote your first link: Accumulating evidence suggests that a subgroup of patients with severe COVID-19 might have a cytokine storm syndrome.

Explained by espiratory physician John Wilson in the article "Coronavirus: what happens to people's lungs when they get Covid-19?"

https://www.theguardian.com/world/2020/mar/20/coronavirus-wh...

"How does the pneumonia develop?

When people with Covid-19 develop a cough and fever, Wilson says this is a result of the infection reaching the respiratory tree – the air passages that conduct air between the lungs and the outside.

He says: “The lining of the respiratory tree becomes injured, causing inflammation. This in turn irritates the nerves in the lining of the airway. Just a speck of dust can stimulate a cough.

“But if this gets worse, it goes past just the lining of the airway and goes to the gas exchange units, which are at the end of the air passages.

“If they become infected they respond by pouring out inflammatory material into the air sacs that are at the bottom of our lungs.”

If the air sacs then become inflamed, Wilson says this causes an “outpouring of inflammatory material [fluid and inflammatory cells] into the lungs and we end up with pneumonia.”

He says lungs that become filled with inflammatory material are unable to get enough oxygen to the bloodstream, reducing the body’s ability to take on oxygen and get rid of carbon dioxide.

“That’s the usual cause of death with severe pneumonia,” he says.

" The last 3 paragraphs are a description of the "cytokine storm".

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#263

Post by WilsonPaige »

jimmyswimmy wrote: post #28
WilsonPaige wrote: post #2

Then we have a treatment (i.e., zinc gluconate + chloroquine): A zinc tablet (10-80 mg) dissolved slowly in the mouth, lavaging the throat and nose, while lying down will cease coronaviral replication on most of the surfaces of the upper respiratory system. Zinc sprays also work. This must be done within the first 3-4 days of infection with covid-19. The covid-19 virus' usual course is to first infect the eye, nose a…

So, I'm no medical professional, just an avid reader of such news. But I believe that most of this post is incorrect. I've seen no studies backing up the use of zinc for anything related to COVID-19. A search of pubmed for the terms 'covid zinc' or 'coronavirus zinc' show no papers referencing treatments. Same goes for medrxiv. There are a lot of cold "treatments" involving the use of zinc in the way you suggest. I h…

jimmyswimmy says "I've seen no studies backing up the use of zinc for anything related to COVID-19."

It would be very early for posts specific to Covid-19. However that was not the claim: the claim was, verbatim,

"A zinc tablet (10-80 mg) dissolved slowly in the mouth, lavaging the throat and nose, while lying down will cease coronaviral replication on most of the surfaces of the upper respiratory system. Zinc sprays also work. This must be done within the first 3-4 days of infection with covid-19."

Covid-19 is a corona virus and, like all corona viruses, ceases to replicate in the presence of high zinc levels on the epitheleal surfaces. There are many studies re zinc and the way it halts viral replication:

https://www.bing.com/search?q=zinc+halts+viruses+in+vitro&fo...

As I believe I stated ealier, I made no claims as to mechanism.

I wish to point out that probably most of your information about chloroquine is based on the treatment of other diseases, and likely specifically malaria. It is by no means clear that the dose required for malaria is the same as the dose required for Covid-19, which indeed may be an order of magnitude or more less. Time will tell.

As for presenting symptoms, once again I believe this to be take from the malaria playbook. Researchers right now are testing chloroquine for prophylaxis (prevention) as well as treatment, _before_ symptoms present (certainly before serious symptoms present).

What I'm saying is that it is a different ailment and the protocols (and restrictions as to timing) for malaria may, indeed, probably do not apply.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#265

Post by pillefitz »

dmix wrote: post #242
pillefitz wrote: post #130

Earlier quoted context omitted.

Zinc supplementation is an effective treatment against many commonly found viruses. Are you saying the new virus is an exception to this? Seriously curious, as I haven't looked into it specifically. Also: Gargling a zinc/water solution has an astringent effect and removes the bacterial film in your throat, which seems to help in the initial phase of an infection.

The scientific study wasn't even for COVID-19 but another very similar Coronavirus and yes they said it would have no effect on the cells without ionization (specifically zinc entering the cell to blocking an RNA that's needed by the virus to replicate). There was a video of a doctor breaking down the biochemistry of it that got posted here the last time Chloroquine came up, which I can't find just now. If it were on…

Not in direct reply to your post, but slighty interesting anecdata: I likely caught COVID-19 1-2 days ago (light fever, headaches, loss of smell, but no runny nose): I gargled with Zinc as I noticed the first symptoms, had Cinchona bark tea yesterday. After a day, almost all symptoms disappeared except for the loss of smell, which is generally considered a late-stage symptom.

Given that the common cold without any treatment typically lasts around 5 days or so, it might point to some efficacy of the treatment.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#267

Post by narogab »

dmix wrote: post #100
spitfire wrote: post #68

So I’m not seeing mention of this anywhere else chloroquine is being talked about. Chloroquine used to be taken daily in many of the tropical Britain colonies suffering from malaria. chloroquine in the form of quinine is where the gin and tonic drink came from. Quinine mixed with carbonated water was drunk as a prophylactic. The quinine tasted so terrible it had to be cut with something to make it tolerable - gin! Th…

> each day along with a zinc pill. The scientific studies being cited for these COVID-19 vaccines using Chloroquine specifically state zinc supplements by themselves are not ionized and are therefore useless for fighting the virus. Even though zinc entering cells is a key part of how it works, zinc can't enter the cells in question unless it's properly ionized, which is why they use Chloroquine... an ionized zinc del…

drmix says> " zinc can't enter the cells in question unless it's properly ionized, which is why they use Chloroquine.."

Zinc in the bloodstream is ionized zn++. It _can_ enter the cell but not easily. Chloroquine almost literally "opens the front door" to the cell's cytoplasm and any zn++ that stumbles by is pulled in.

But there _is_ a background zn++ level in the bloodstream and it is a gauntlet that every coronavirus must run to get to a cell.

When a cell dies from coronavirus replication, the virii burst into the bloodstream where they are vulnerable to any zn++ present. So high zn++ blood levels may be efficacious.

Once a coronavirus runs the gauntlet and finds its way to a healthy cell, it injects its RNA into the cell. The RNA is now relatively safe from zn++ in the bloodstream (except the few that wander into the cytoplasm by other mechanisms).

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#268

Post by andybak »

CPLX wrote: post #235
arusahni wrote: post #228

Earlier quoted context omitted.

Lariam (Mefloquine) was the one I took in the 90s that had the psychological warnings attached. IIRC, Malarone is newer, and may not align with the OP's timeline.

Whoops. You are correct. We were both wrong, Lariam is what I was thinking of.

Yep. It was Lariam I was thinking of.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#269

Post by giardini »

pillefitz wrote: post #265
dmix wrote: post #242

Earlier quoted context omitted.

The scientific study wasn't even for COVID-19 but another very similar Coronavirus and yes they said it would have no effect on the cells without ionization (specifically zinc entering the cell to blocking an RNA that's needed by the virus to replicate). There was a video of a doctor breaking down the biochemistry of it that got posted here the last time Chloroquine came up, which I can't find just now. If it were on…

Not in direct reply to your post, but slighty interesting anecdata: I likely caught COVID-19 1-2 days ago (light fever, headaches, loss of smell, but no runny nose): I gargled with Zinc as I noticed the first symptoms, had Cinchona bark tea yesterday. After a day, almost all symptoms disappeared except for the loss of smell, which is generally considered a late-stage symptom. Given that the common cold without any tr…

Would you share your recipe for cinchona bark tea? How judge the strength and how much to drink per day?

I bought some cinchona bark (cut, but is powdery) and they have a recipe on the bag but no specification of strength or how much to drink.

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