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Chloroquine has shown apparent efficacy in treatment of Covid-19

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Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#201
post #138

Earlier quoted context omitted.

Dr Raoult reports that after 6 days of treatment with Plaquenil (hydroxychloroquine) only 25% were still carrying the virus. Without treatment, 80% were still carrying the virus after 6 days. This result should be published soon.

But does that mean anything? Without hydroxychloroquine, how many people stop shedding active virus because the immune system starts to respond by day 6 of symptoms? It seems to be about the same.

People carry it for up to five weeks.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#202
post #174

Earlier quoted context omitted.

Because testing everybody is no big deal.

Wasn’t there a $1 test being proposed? You can start by testing people with high temperature at the entrance of buildings and metro. Still cheaper that closing schools and all the rest of the economy.

Proposed, yes, but you can't buy it yet. Also, the cheaper tests so far are all antibody tests, not the more accurate RNA tests that everyone is clamoring for. Antibody tests don't work until you have had the infection for a while.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#203
post #174

Earlier quoted context omitted.

Wasn’t there a $1 test being proposed? You can start by testing people with high temperature at the entrance of buildings and metro. Still cheaper that closing schools and all the rest of the economy.

Proposed, yes, but you can't buy it yet. Also, the cheaper tests so far are all antibody tests, not the more accurate RNA tests that everyone is clamoring for. Antibody tests don't work until you have had the infection for a while.

And they are even worse at telling you when you're "all clear" (if they can do it at all, many antibody tests are a "once positive, always positive" deal).

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#204

So I’m not seeing mention of this anywhere else chloroquine is being talked about. Chloroquine used to be taken daily in many of the tropical Britain colonies suffering from malaria. chloroquine in the form of quinine is where the gin and tonic drink came from. Quinine mixed with carbonated water was drunk as a prophylactic. The quinine tasted so terrible it had to be cut with something to make it tolerable - gin! Th…

so it must be have been a British conspiracy. I knew it all along.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#205

> It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system ... The wholesale cost in the developing world is about US$0.04. In the United States, it costs about US$5.30 per dose. [1] That's a little over 132x more expensive. Compared to other common medicines like ibuprofen ($0.04 in the developing world, $0.05 in the USA [2]), what makes…

Its a prescription drug in the US, and pharmacists get paid a bunch. Most developing countries you can buy OTC.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#206
post #151

> It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system ... The wholesale cost in the developing world is about US$0.04. In the United States, it costs about US$5.30 per dose. [1] That's a little over 132x more expensive. Compared to other common medicines like ibuprofen ($0.04 in the developing world, $0.05 in the USA [2]), what makes…

The Lancet has published a study this week that anti-inflamatory drugs may help Ncovid penetrate cell walls and actually speed up the process. France has stopped over-the-counter sales of Ibuprofen as of mid January. https://www.afrinik.com/anti-inflammatory-drugs-can-make-cor...

Not familiar with afrinik, but this has been reported in The Guardian

https://www.theguardian.com/world/2020/mar/16/health-experts...

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#207

Earlier quoted context omitted.

This has been disputed: "This speculation about the safety of ACE-i or ARB treatment in relation to COVID-19 does not have a sound scientific basis or evidence to support it. Indeed, there is evidence from studies in animals suggesting that these medications might be rather protective against serious lung complications in patients with COVID-19 infection, but to date there is no data in humans. The Council on Hyperte…

That is not actually a refutation.

Not a native speaker, but refutation to me translates to disputed… anyways edited for clarity.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#208

> It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system ... The wholesale cost in the developing world is about US$0.04. In the United States, it costs about US$5.30 per dose. [1] That's a little over 132x more expensive. Compared to other common medicines like ibuprofen ($0.04 in the developing world, $0.05 in the USA [2]), what makes…

I have in-laws in Nigeria. We just tipped them off a couple of days ago that now might be a good time to buy some Chloroquine and keep at the house, in case the situation gets worse. This is a commonly known medicine down there, that you can get from pharmacies without prescription. But based on what we're seeing so far, it seems plausible that this virus prefers cooler northern climates. So hopefully it will turn ou…

Sorry, I'm now picturing email offers from Nigerians that I would openly welcome.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#209
post #75
post #44

This is an increadibly potent drug with serious side effects according to anything I read, its not first-line treatment its last-line, when everything else fails. You can go blind, irreversibly. Please people, speak to trained medical people before reaching to the drug cabinet. I am not a doctor. This advice is not meant to contradict the rule of only taking medical advice from medical professionals.

You can just buy it over-the-counter in some countries, right? How dangerous can it really be? Follow the instructions on the box like citizens of those countries do. IMO we in the US need to take the coronavirus as a wake up call to stop ignoring the medical systems of other countries and admit that they might have something to teach us. We shouldn’t just assume the American medical system is always the best one.

The therapeutic window for chloroquine is small, and there are very adverse side-effects if overdosed (heart arrythmias being the most dramatic I guess but macular toxicity is not something you'd want to risk either). I actually heard a story on that's how they dosed it "back in the days" - the sailors took it until they fainted our of various heart arrythmias and then they knew they had to back down a bit next time..

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#210

Earlier quoted context omitted.

That is not actually a refutation.

Not a native speaker, but refutation to me translates to disputed… anyways edited for clarity.

To dispute something usually just means to disagree with it. Refutation generally implies positive evidence that a position is wrong.
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