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Chloroquine has shown apparent efficacy in treatment of Covid-19

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Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#51

Post by IAmEveryone »

ethbro wrote: post #6
WilsonPaige wrote: post #2

Then we have a treatment (i.e., zinc gluconate + chloroquine): A zinc tablet (10-80 mg) dissolved slowly in the mouth, lavaging the throat and nose, while lying down will cease coronaviral replication on most of the surfaces of the upper respiratory system. Zinc sprays also work. This must be done within the first 3-4 days of infection with covid-19. The covid-19 virus' usual course is to first infect the eye, nose a…

> allowing time to clear the virus from the body without raising an excessive immune response ("cytokine storm") Citation requested, that cytokine storms are a common pathology associated with Covid-19. Because (a) I haven't seen that in the literature, & (b) it's at odds with the published age-banded mortality rates.

For reasons beyond my understanding, the internet (or maybe just HN) has been in love with cytokines storms for a decade or so. Far more than warranted by the actual significance of the phenomenon relative to others.

It’s like quicksand in 19th century pop culture.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#53

Post by forkexec »

ridgeguy wrote: post #42
monkeygus wrote: post #34

i currently take Plaquenil (Hydroxychloroquine) for rheumatoid arthritis, and my doctor did indicate it may be helpful against Covid but not enough tests to confirm. Is it close enough to chloroquine to be the same ?

The paper says clinical tests used both chloroquine and hydroxychloroquine. In discussing the results, they don't seem to differentiate between the two, unless I missed it.

When administering chloroquine, the hydroxy- form is a very long-lasting metabolite.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#54

Post by drewmol »

monkeygus wrote: post #34

i currently take Plaquenil (Hydroxychloroquine) for rheumatoid arthritis, and my doctor did indicate it may be helpful against Covid but not enough tests to confirm. Is it close enough to chloroquine to be the same ?

"Hydroxychloroquine (EC50=0.72 μM) was found to be more potent than chloroquine (EC50=5.47 μM) in vitro. Based on PBPK models results, a loading dose of 400 mg twice daily of hydroxychloroquine sulfate given orally, followed by a maintenance dose of 200 mg given twice daily for 4 days is recommended for SARS-CoV-2 infection, as it reached three times the potency of chloroquine phosphate when given 500 mg twice daily 5 days in advance."

https://academic.oup.com/cid/advance-article/doi/10.1093/cid...

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#55

Post by jinlu »

monkeygus wrote: post #34

i currently take Plaquenil (Hydroxychloroquine) for rheumatoid arthritis, and my doctor did indicate it may be helpful against Covid but not enough tests to confirm. Is it close enough to chloroquine to be the same ?

Hydroxychloroquine has been used in ShangHai for COVID-19 treatment since February 6, 2020:

https://clinicaltrials.gov/ct2/show/NCT04261517

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#57

Post by IAmEveryone »

Udik wrote: post #19
petecox wrote: post #15

Earlier quoted context omitted.

It's commonly used for malaria. A related '-quine' is the active ingredient of Gin and Tonic.

The active ingredient of gin & tonic is definitely alcohol :)

Tonic was invented to make quinine palatable to British soldiers in India. About three minutes into the scheme, someone added gin.

So quinine is indeed arguably the original “active” ingredient, sugar was second (to mask the flavor), and alcohol “let’s just pretend this isn’t happening” was third.

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#58

Post by checker659 »

ggm wrote: post #44

This is an increadibly potent drug with serious side effects according to anything I read, its not first-line treatment its last-line, when everything else fails. You can go blind, irreversibly. Please people, speak to trained medical people before reaching to the drug cabinet. I am not a doctor. This advice is not meant to contradict the rule of only taking medical advice from medical professionals.

The retinopathy happens only after years of use (like a decade). Also, as an immunosuppressant, it is pretty slow acting in that it takes two three months to even start working. The currently prescribed dosage for the viral infection is for 5-10 days (albeit at slightly higher dosage than used for malaria/lupus etc.).

Re: Chloroquine has shown apparent efficacy in treatment of Covid-19

#59

Post by dboreham »

beager wrote: post #41

I've seen chloroquine come up a ton and am hopeful for the efficacy of its use in treatment of COVID-19. It's surreal to be observing the global impact of a novel pandemic, and anything that can save lives or blunt the propagation of the virus feels like a gasp of hope. Of course, chloroquine is not a vaccine, it's not a tool to contain the spread of SARS-CoV-2. We need massive and rapid propagation of testing, and m…

Except a vaccine won't be ready until long after everyone is either dead or recovered.
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