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Diabetes in mice cured rapidly using human stem cell strategy

medicine.wustl.edu

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Re: Diabetes in mice cured rapidly using human stem cell strategy

#51

Post by jfritsch1984 »

root_axis wrote: post #46
Amygaz wrote: post #7

Earlier quoted context omitted.

I stopped counting how many times we cured any forms of diabetes in various mouse models. Then there is this thing that bugs me: amount of money spent on finding a treatment vs. preventing type 2 diabetes in the first place. Because 95% of type 2 cases are caused by life style decisions. And as climate change, healthcare costs, covid-19, and other self-inflicted societal crises we prefer to wait until it chronically…

> 95% of type 2 cases are caused by life style decisions Do you have a source for that claim? My understanding is that genetics is the primary risk factor for diabetes.

Check Adventist health study 2. Vegans for example had 60-70% less diabetes. Guess they had the same genes before choosing that diet.

Re: Diabetes in mice cured rapidly using human stem cell strategy

#52

Post by jfritsch1984 »

flexblue wrote: post #30
pengaru wrote: post #24

Earlier quoted context omitted.

> Bananas by themselves are not healthy food, they're very high in sugar and have little else to offer. That depends on ripeness [0], I eat a mostly green banana every morning and it doesn't have much sugar at all while keeping my bowels very regular. It's been my breakfast for decades, I'm quite healthy, and eat a diet almost entirely composed of raw produce. The rest is nuts/seeds/legumes and canned fish. I rarely…

> It's been my breakfast for decades, I'm quite healthy, and eat a diet almost entirely composed of raw produce. The rest is nuts/seeds/legumes and canned fish. You get virtually all of your macronutrients from the nuts, seeds, legumes and the fish - not the produce. > I rarely ever cook, and if I didn't go for organic produce this would be a very cheap diet except for the nuts. So it would be cheap if it was somethi…

People eat beans for decades. Why should this be an experiment? Because people like Dr. Gundry want to sell books? He‘s even admitted on TV that cooking mitigates the whole problem. And who eats raw beans? I think it‘s pure hysteria. In observational studies „anti-nutrients“ are mostly associated with better health outcomes.

Re: Diabetes in mice cured rapidly using human stem cell strategy

#53

Post by jfritsch1984 »

pengaru wrote: post #19
jfritsch1984 wrote: post #11

Earlier quoted context omitted.

Healthy food is typically less expensive than junk food. The problem is education and motivation. I think diabetes is more a disease of affluence. When you can buy twinkies and pork chops you're not actually poor. When you are really poor you eat rice and beans and some vegetables you grow for yourself. And then you don't have diabetes typically. Disclaimer: Not every T2D is purely from a bad diet. But many are.

> When you can buy twinkies and pork chops you're not actually poor. When you are really poor you eat rice and beans and some vegetables you grow for yourself. And then you don't have diabetes typically. The EBT program here in the US completely distorts the situation. My local grocery store serves a very poor community, most of the customers pay with EBT. I get to see what kind of things these folks buy, it's idioti…

As I said: These people should be educated and motivated. They have to learn about the consequences of these decisions. Only if that does not work I would restrict EBT to healthier foods.

On a personal note: I agree with you. It‘s hilarious what people buy even when they are on a tight budget.

Re: Diabetes in mice cured rapidly using human stem cell strategy

#54

Post by flexblue »

jfritsch1984 wrote: post #50
flexblue wrote: post #25

Earlier quoted context omitted.

Without any further context, this is most likely not a healthy diet. You're certainly missing out on B vitamins and heme iron due to lack of meat and likely have a poor Omega 6 to Omega 3 ratio due to the use of plant oils over other fats. Just a guess. You also probably get way too much sugar from sugary fruits which you overindulge in because your diet otherwise is so "healthy". Instead of soft drinks you have frui…

I did my research. Also I tracked my nutrition with Cronometer in the first weeks. Not a single day did I miss on B-vitamins. Heme iron is associated with disease in all major studies. I don‘t see a reason to ingest it. I have a great O3/O6 ratio. I don‘t use oil at all and avoid foods that are filled with plant oils. My breakfast contains lots of flax seeds. Our usual foods contain hemp seeds. All good sources of O3…

> I did my research. Also I tracked my nutrition with Cronometer in the first weeks. Not a single day did I miss on B-vitamins.

If you didn't have any animal foods, you're going to be missing out on B-vitamins, because of low bioavailability[1].

> Heme iron is associated with disease in all major studies. I don‘t see a reason to ingest it.

An excess of many essential nutrients and vitamins is associated with disease, that doesn't mean you should cut them out. Non-heme iron is way less bioavailable, especially in combination with plant antinutrients[2], so you can end up iron-deficient.

> I have a great O3/O6 ratio. I don‘t use oil at all and avoid foods that are filled with plant oils.

You probably should be using oil, just not plant oils.

> My breakfast contains lots of flax seeds. Our usual foods contain hemp seeds. All good sources of O3.

Unfortunately not, because those sources also have low bio-availability.

> And all without pollutants from fish.

Pollutants are unfortunate, but when it comes to nutrition, you have to pick your poisen. Salmon roe is a good source of Omega 3 that is low in pollutants.

> I get a lot of information from nutritionfacts.org. Dr. Greger offers free information as in free beer. No ads, no sponsors, even the earnings from his books are given to charity. I highly recommend you check him out. He certainly has his biases but still way less than most other doctors.

A plant-based diet is ideology that is cherry-picking and misrepresenting some insights of nutrition science while sweeping others under the rug. With his exaggerated claims[4], Greger isn't any more credible than certain people on "the other side".

[1] https://www.ncbi.nlm.nih.gov/pubmed/2843032

[2] https://academic.oup.com/ajcn/article/91/5/1461S/4597424

[3] https://www.ncbi.nlm.nih.gov/pubmed/24261532

[4] https://sciencebasedmedicine.org/death-as-a-foodborne-illnes...

Re: Diabetes in mice cured rapidly using human stem cell strategy

#55

Post by flexblue »

jfritsch1984 wrote: post #52
flexblue wrote: post #30

Earlier quoted context omitted.

> It's been my breakfast for decades, I'm quite healthy, and eat a diet almost entirely composed of raw produce. The rest is nuts/seeds/legumes and canned fish. You get virtually all of your macronutrients from the nuts, seeds, legumes and the fish - not the produce. > I rarely ever cook, and if I didn't go for organic produce this would be a very cheap diet except for the nuts. So it would be cheap if it was somethi…

People eat beans for decades. Why should this be an experiment? Because people like Dr. Gundry want to sell books? He‘s even admitted on TV that cooking mitigates the whole problem. And who eats raw beans? I think it‘s pure hysteria. In observational studies „anti-nutrients“ are mostly associated with better health outcomes.

> People eat beans for decades. Why should this be an experiment?

People also eat donuts for decades, that means nothing.

People didn't eat beans for hundreds of thousands of years. They're not a "natural" part of the diet. They contain poorly researched plant toxins and anti-nutrients, which can are known to cause issues in sensitive people.

Can you "mitigate" the problem with proper preparation? Apparently, but that doesn't mean we know they are actually healthy as opposed to "sustainable". Populations across the world which have no choice but to rely on grains and legumes as a staple do suffer from malnutrition.

> In observational studies „anti-nutrients“ are mostly associated with better health outcomes.

Observational studies are mostly useless, because anybody who buys into "legumes are healthy" will focus on living a healthy life in other aspects as well. As I said, swapping in legumes in place of donuts is going to be a benefit. That doesn't mean it's optimal.

Re: Diabetes in mice cured rapidly using human stem cell strategy

#56

Post by jfritsch1984 »

flexblue wrote: post #55
jfritsch1984 wrote: post #52

Earlier quoted context omitted.

People eat beans for decades. Why should this be an experiment? Because people like Dr. Gundry want to sell books? He‘s even admitted on TV that cooking mitigates the whole problem. And who eats raw beans? I think it‘s pure hysteria. In observational studies „anti-nutrients“ are mostly associated with better health outcomes.

> People eat beans for decades. Why should this be an experiment? People also eat donuts for decades, that means nothing. People didn't eat beans for hundreds of thousands of years. They're not a "natural" part of the diet. They contain poorly researched plant toxins and anti-nutrients, which can are known to cause issues in sensitive people. Can you "mitigate" the problem with proper preparation? Apparently, but tha…

You say that beans are problematic but you don‘t back it up. I only have to show you that beans are just as much part of human diets as are other foods. What is the actual science that anybody on earth suffers from the consumption of beans? For donuts we see a direct correlation between sugary processed foods and obesity, T2D and other diseases. For beans you can not show this. The only thing you can show is some mechanistic data, where we can speculate. In my personal opinion you are the victim of an industry that wants to sell stuff like Gundrys supplements like „Lectin buster“ and the like.

Re: Diabetes in mice cured rapidly using human stem cell strategy

#57

Post by geden »

Closed loop insulin delivery systems functionally “cure” t1 diabetics and are here today. Have implemented for a t1 friend. Has transformed his long term outlook.

https://loopkit.github.io/loopdocs/

Relies on currently quite expensive hardware (continuous glucose monitors / insulin pump / iPhone / Bluetooth to radio device) but that could all be combined into 2 cheap devices easily. Regulation and inertia just seems to be making that process very slow.

Re: Diabetes in mice cured rapidly using human stem cell strategy

#58

Post by jfritsch1984 »

flexblue wrote: post #54
jfritsch1984 wrote: post #50

Earlier quoted context omitted.

I did my research. Also I tracked my nutrition with Cronometer in the first weeks. Not a single day did I miss on B-vitamins. Heme iron is associated with disease in all major studies. I don‘t see a reason to ingest it. I have a great O3/O6 ratio. I don‘t use oil at all and avoid foods that are filled with plant oils. My breakfast contains lots of flax seeds. Our usual foods contain hemp seeds. All good sources of O3…

> I did my research. Also I tracked my nutrition with Cronometer in the first weeks. Not a single day did I miss on B-vitamins. If you didn't have any animal foods, you're going to be missing out on B-vitamins, because of low bioavailability[1]. > Heme iron is associated with disease in all major studies. I don‘t see a reason to ingest it. An excess of many essential nutrients and vitamins is associated with disease,…

I think it is not productive to have this discussion. I have good blood markers after 6 years on this diet. LDL of 52. BP of 101/74. So for me this diet is way healthier than the omnivorous diet that I had before. If you want to believe that animals are essential for human health, go on. But in my opinion science does not back this up. But that is my interpretation.

Your thoughts on bioavailability are also outdated. It has been shown for protein, iron and some vitamins that bioavailability in practice is very good for plant sources. E.g. iron is converted as good as heme iron when combined with vitamin C. And it‘s hard to avoid C on a plant based diet.

May I ask where you get your information from?

Re: Diabetes in mice cured rapidly using human stem cell strategy

#59

Post by jfritsch1984 »

flexblue wrote: post #54
jfritsch1984 wrote: post #50

Earlier quoted context omitted.

I did my research. Also I tracked my nutrition with Cronometer in the first weeks. Not a single day did I miss on B-vitamins. Heme iron is associated with disease in all major studies. I don‘t see a reason to ingest it. I have a great O3/O6 ratio. I don‘t use oil at all and avoid foods that are filled with plant oils. My breakfast contains lots of flax seeds. Our usual foods contain hemp seeds. All good sources of O3…

> I did my research. Also I tracked my nutrition with Cronometer in the first weeks. Not a single day did I miss on B-vitamins. If you didn't have any animal foods, you're going to be missing out on B-vitamins, because of low bioavailability[1]. > Heme iron is associated with disease in all major studies. I don‘t see a reason to ingest it. An excess of many essential nutrients and vitamins is associated with disease,…

Regarding B6. The last days that I tracked I had 3-4 times the RDA of B6 with ~4mg. Even if the absorption were really low I still meet what my body needs. And other sources report way better absorption rates.

Re: Diabetes in mice cured rapidly using human stem cell strategy

#60

Post by jfritsch1984 »

flexblue wrote: post #20
jfritsch1984 wrote: post #16

Earlier quoted context omitted.

Could you tell me why rice and beans are problematic? The studies I know are typically in favor of these kinds of food. Bean consumption is typically a good predictor for survival in elderly people. Is this some kind of carb-phobia?

In the context of T2 diabetes, white rice is a high GI food. Brown rice, legumes and grains contain plant toxins and antinutrients which are poorly researched, but at least anecdotally can cause all kinds of issues especially in sensitive people. Also, in the west, a lot of the culture of preparing these foods (such as fermenting or vigorous soaking) is bypassed. > Bean consumption is typically a good predictor for s…

Your beanphobia is even addressed by the Huffington Post: https://www.huffpost.com/entry/beans-calmin-the-fears_b_6464...
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