Live data from Hacker News

Chloroquine phosphate has shown apparent efficacy in treating Covid-19

ncbi.nlm.nih.gov

31–40 of 174 posts

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#32

Honestly this is a perfect example of a time when laws are excessively restrictive. I should have the right to purchase this drug and use it as a last resort in the case that I or my family are infected. It's not fair to responsible people who are capable of researching safety and dosages to have to pay for the ignorance of others. Especially when this drug is OTC in most of the world. You don't need a medical degree…

I'm reasonably sure having hospitals run out of it because it was hoarded by preppers is not a desirable outcome.

Limiting the quantity that can be purchased to a particular address or credit card or similar restriction can help with this problem.

As can inflating the price (high taxes) for non-doctors who are purchasing preemptively. If you are sick, go to a doctor and get it at the normal price. If you are a prepper, pay extra, buy less.

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#33
post #30
post #28

Zinc. Chloroquine provides zinc and ionosphere for absorbtion that likely stops replicase.

Yes, I was reading about this recently. Another study compared zinc uptake into the cytosol for various extracellular zinc levels, with and without chloroquine. I noticed when looking at the data, that while chloroquine facilitated a massive uptake a zinc, it was still true that increasing the extracellular zinc concentration (without chloroquine) still increased the cytosol's zinc concentration (by a lesser amount).…

One of the side effects of zinc overdose is loss of sense of smell, sometimes permanently. Please research all aspects before use.

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#34

Earlier quoted context omitted.

That's a patently ridiculous reason to make a drug illegal to own without a prescription. Should we also outlaw non Rx toilet paper? Hospitals have supply chains that are separate from pharmacies and grocery stores. This is a non sequitur. What about masks? Should they be preemptively made Rx only when all this is said and done because people hoarded them? What about the fact that evidence of Chloroquine's likely eff…

In emergencies it is pretty standard procedures to ration essential stuff in limited supplies. Food is regularly rationed during war times. It would not be ridiculous at all to limit the use of an OTC drug to hospitals during an emergency, if there is limited supply (don't know if that's the case with chloroquine). BTW cloroquine+antivirals is pretty much the first line drug treatment in Italy, at least according to…

>In emergencies it is pretty standard procedures to ration essential stuff in limited supplies

We're talking about laws restricting free access to drugs before emergencies, not emergency quarantine.

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#35

Earlier quoted context omitted.

That's a patently ridiculous reason to make a drug illegal to own without a prescription. Should we also outlaw non Rx toilet paper? Hospitals have supply chains that are separate from pharmacies and grocery stores. This is a non sequitur. What about masks? Should they be preemptively made Rx only when all this is said and done because people hoarded them? What about the fact that evidence of Chloroquine's likely eff…

Considering that news of coronavirus is so widespread that you're apparently aware of this, I would think that most doctors are probably aware of this too.

Medical personnel outside of China were still laughing this off as "just another flu" until mid February at the earliest. Unfortunately all I have is anecdote...but it took far too long for people to take this seriously, because doctors are humans too and aren't necessarily trawling internet forums for happenings.

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#36
In Africa when you suffer from Malaria they gradually give you Chloroquine, Amodiaquine or even Quinine. From my experience, Quinine is the strongest. I grew up taking those medicines. Man. They knock you out. Your ears are no longer working the first 3 days of taking Quinine. You lose the sense of smell. I guess they slow down the Corona 19 virus. My mom has already sent me Amodiaquine and Quinine here in Italy.

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#37
post #6
post #5

For a slightly more balanced perspective, try this paper: https://www.sciencedirect.com/science/article/pii/S016635422... : Highlights from that paper (all of which look quite reasonable to me, as a non-expert): • In vitro data suggest that chloroquine inhibits SARS Cov-2 replication. • In past research, chloroquine has shown in vitro activity against many different viruses, but no benefit in animal models. • Chloroq…

>The outcomes of some current clinical trials of chloroquine in China have been announced, without access to the data. This seems to be the link to the details of clinical trials in China that are made available http://www.chictr.org.cn/searchproj.aspx?title=氯喹&officialna...

I checked the most recent result from that search: http://www.chictr.org.cn/showproj.aspx?proj=50843

At the very bottom, it says "original data will be published on web-based public database in 6 months after the research" which is a bit disappointing.

Re: Chloroquine phosphate has shown apparent efficacy in treating Covid-19

#38
post #33
post #30

Earlier quoted context omitted.

Yes, I was reading about this recently. Another study compared zinc uptake into the cytosol for various extracellular zinc levels, with and without chloroquine. I noticed when looking at the data, that while chloroquine facilitated a massive uptake a zinc, it was still true that increasing the extracellular zinc concentration (without chloroquine) still increased the cytosol's zinc concentration (by a lesser amount).…

One of the side effects of zinc overdose is loss of sense of smell, sometimes permanently. Please research all aspects before use.

you'd have to take ridiculous amounts of zinc for long periods of time for that to happen.
Post reply on HN