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The neuroinvasive potential of SARS-CoV2

ncbi.nlm.nih.gov

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Re: The neuroinvasive potential of SARS-CoV2

#111

Post by Proziam »

NhanH wrote: post #85
Proziam wrote: post #63

Earlier quoted context omitted.

EDIT - Just to be clear, I'm not saying that people shouldn't take precautions or that it's not worth protecting vulnerable groups. I'm simply suggesting that perhaps there is news coverage about other things (remember the whole Hong Kong situation that we aren't hearing about suddenly?) that might still deserve some air time. The media is profiting off this story big time. It's like when the plane went missing and a…

It is getting annoying that people keeps comparing different numbers to make their points. If you are using 0.2% mortality rate in a healthy population, you have to compare it with the flu mortality's rate in a healthy population, which is still a magnitude lower. It's disgraceful, to be honest, to compare mortality rates on different population at all. And I'm just gonna quote your link directly to make my point, I'…

So, in your opinion, the news coverage is totally justified and the lack of coverage for every other subject is okay? There's already 'effective interventions' being discussed openly from n95 masks to quarantines and travel restrictions.

Getting irritated at me for pointing out that the average person is not at severe risk of death, contrary to what the media is currently saying, seems a bit of an over-reaction.

Re: The neuroinvasive potential of SARS-CoV2

#112

Post by rolph »

pbhjpbhj wrote: post #105
sndean wrote: post #19

Earlier quoted context omitted.

It looks like CDC recommends to use them for ≤ 8 hours (continuous or intermittent) [0]. [0] https://www.cdc.gov/niosh/topics/hcwcontrols/recommendedguid...

Presumably their effectiveness is reduced then, rather than negated. Aren't they just close bound fibres that form a filter?

they may become fomitic , actually carrying aggregations of virions nestled in expectorated particles of mucous

Re: The neuroinvasive potential of SARS-CoV2

#113

Post by geggam »

allendoerfer wrote: post #76
drcode wrote: post #62

Earlier quoted context omitted.

Telling people they should wear masks because they don't put them on properly is like telling people they shouldn't drive cars because some people drive them into trees.

I am bookmarking this comment for the time after self-driving cars have become universally available.

given the longevity of webservices online I bet HN is gone before that day happens

Re: The neuroinvasive potential of SARS-CoV2

#114

Post by daun »

I was actually wondering about this because both the Spanish Flu and the 2009 H1N1 pandemics left life-long brain damage for some survivors in the form of narcolepsy with cataplexy. The vaccine for H1N1 caused it in a very small amount of patients as well. After the Spanish Flu they called it "encephalitis lethargica". It appears that it damages the hypothalamus.

Re: The neuroinvasive potential of SARS-CoV2

#115

Post by jklhjklhtoeiru »

StanislavPetrov wrote: post #77
morpheuskafka wrote: post #15

Earlier quoted context omitted.

Yes, only a N95 or better mask would protect you from incoming, as opposed to outgoing, viruses, and these masks are both impractical for everyday wear and need to be conserved for public health users.

>need to be conserved for public health users. I think we should all ask ourselves why we take it for granted that we should simply have to ration masks. Why aren't there enough masks available for everyone for inevitable outbreaks like this? Why don't we have the industrial capacity to manufacture masks in the US, leaving us reliant on foreign imports? We spend ~$80 billion dollars a month on our endless war, milita…

There was an article recently about an US mask manufacturer (small one, not 3M), which for years warned that this will happen: a pandemic will hit and there will be a severe lack of masks anywhere.

He also recounted how after the 2009 flu scare everyone was telling him how after it ends they will now stockpile masks to be ready for the next one, he increased production, but then was stuck with it because people stopped taking his calls the moment the flu faded.

Re: The neuroinvasive potential of SARS-CoV2

#116

Post by wintorez »

morpheuskafka wrote: post #15
aazaa wrote: post #10

From the paper: > If the neuroinvasion of SARS-CoV-2 does take a part in the development of respiratory failure in COVID-19 patients, the precaution with masks will absolutely be the most effective measure to protect against the possible entry of the virus into the CNS. It may also be expected that the symptoms of the patients infected via facal-oral or conjunctival route will be lighter than those infected intranasa…

Yes, only a N95 or better mask would protect you from incoming, as opposed to outgoing, viruses, and these masks are both impractical for everyday wear and need to be conserved for public health users.

Also, you need to wear eye protection as well.

Re: The neuroinvasive potential of SARS-CoV2

#118

Post by fooey »

Proziam wrote: post #63
thijsvandien wrote: post #32

As a side observation: most reporting seems rather binary, i.e. you either die or survive, period. What interests me the most, however, is how often survival means full recovery, especially now that the nervous system comes up. Are there any long term effects? Should one generally expect to come out of it worse, the same, or stronger? I'm much less afraid to die from this than to end up with chronic respiratory and/o…

EDIT - Just to be clear, I'm not saying that people shouldn't take precautions or that it's not worth protecting vulnerable groups. I'm simply suggesting that perhaps there is news coverage about other things (remember the whole Hong Kong situation that we aren't hearing about suddenly?) that might still deserve some air time. The media is profiting off this story big time. It's like when the plane went missing and a…

Given there's no herd immunity, and the virulance of the strain, estimates are 40-70% of the population will contract the virus within a year

0.2% of 40% of the US Population is 260,000 deaths within a year[1]

"it's just the flu" greatly underappreciates just how deadly influenza actually is

If the mortality rate is more in the 2%+ range, we're looking at millions of deaths in the US alone.

[1] https://www.wolframalpha.com/input/?i=0.2%25+of+40%25+of+US+...

Re: The neuroinvasive potential of SARS-CoV2

#119

Post by t420mom »

tjt wrote: post #57
aazaa wrote: post #10

From the paper: > If the neuroinvasion of SARS-CoV-2 does take a part in the development of respiratory failure in COVID-19 patients, the precaution with masks will absolutely be the most effective measure to protect against the possible entry of the virus into the CNS. It may also be expected that the symptoms of the patients infected via facal-oral or conjunctival route will be lighter than those infected intranasa…

This is super scary. Before I read this I was happily thinking hey it's no worse than flu. Now... I'm wishing I didn't live in a huge city riding the subway daily.

Are you able to ride a bike to work?

Re: The neuroinvasive potential of SARS-CoV2

#120

Post by rolph »

aqme28 wrote: post #82
thijsvandien wrote: post #32

As a side observation: most reporting seems rather binary, i.e. you either die or survive, period. What interests me the most, however, is how often survival means full recovery, especially now that the nervous system comes up. Are there any long term effects? Should one generally expect to come out of it worse, the same, or stronger? I'm much less afraid to die from this than to end up with chronic respiratory and/o…

This is also something I'm curious about. SARS caused permanent lung damage in a large proportion of the survivors, sometimes to a debilitating extent. How common is that with nCov?

it is very likely the same circumstance.both those virus conserve the same cell fusion machinery, to the end of causing the same effect. The host may be variable and there is a basis for the range of morbidities observed. the central problem with lung damage involves disruptions to the RAS system that will lead to accumulations of extracellular fibres in the lung tissue
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