Angiotensin converting enzyme 2 (ACE2) crucial in SARS-coronavirus lung injury (2005)

Post by rolph » Sun, Mar 01, 2020, 6:03 PM UTC

chroem- wrote: post #8

epmaybe wrote: post #6

Earlier quoted context omitted.

Another interesting side effect could be other temporizing measures in the inpatient setting. My understanding from a brief skim of older research papers is that the ACE inhibitors and angiotensin receptor blockers that we use today, like lisinopril or losartan, could upregulate the expression of ACE-2 receptors. If a patient is admitted with coronavirus, discontinuing blood pressure medications such as lisinopril an…

I suppose that explains why a lot (most?) of the people who died also suffered from high blood pressure.

Post by pezo1919 » Sun, Mar 01, 2020, 6:23 PM UTC

caycep wrote: post #7

jfries wrote: post #3

What are the implications of this?

the meds modulating ACE family of proteins are also commonly available as blood pressure meds, actually. But interestingly, the side effect is...coughing... But the research behind what is needed to modulate ACE is already there..

Post by pezo1919 » Sun, Mar 01, 2020, 6:31 PM UTC

caycep wrote: post #7

jfries wrote: post #3

What are the implications of this?

the meds modulating ACE family of proteins are also commonly available as blood pressure meds, actually. But interestingly, the side effect is...coughing... But the research behind what is needed to modulate ACE is already there..

Post by rolph » Sun, Mar 01, 2020, 6:33 PM UTC

pezo1919 wrote: post #15

caycep wrote: post #7

Earlier quoted context omitted.

the meds modulating ACE family of proteins are also commonly available as blood pressure meds, actually. But interestingly, the side effect is...coughing... But the research behind what is needed to modulate ACE is already there..

Does modulation mean increasing or decreasing ACE2? I assume it decreases and its good, right?

Post by pezo1919 » Sun, Mar 01, 2020, 6:39 PM UTC

epmaybe wrote: post #6

rolph wrote: post #4

Earlier quoted context omitted.

this is the mechanism a coronavirus assembly exploits to enter a cell. the virion uses a peplomer [one of its spikes] to dock with the cell at the ACE2 receptor then wrenches it apart like cutting a door right out of its frame, then the virus inserts itself into the cell leaving its envelope and protien accessories fused with the cell membrane. -if this mechanism can be blocked it will inhibit viral entry -if it can…

Another interesting side effect could be other temporizing measures in the inpatient setting. My understanding from a brief skim of older research papers is that the ACE inhibitors and angiotensin receptor blockers that we use today, like lisinopril or losartan, could upregulate the expression of ACE-2 receptors. If a patient is admitted with coronavirus, discontinuing blood pressure medications such as lisinopril an…