The issue I find with "flexibility to work from home" is that if it's conditional / occasional then it's also an outlier, and you're not used to working that way. This is why most "telework" programs are weird - because people that are teleworking are seen as goofing off in their pajamas or somehow disconnected.
If you're fully remote then you need to behave that way even when you're in an office environment. Sure, have in-person meetings when you can, but make sure remote folks are 100% present and enabled, otherwise those that choose to work from home will be less present - even in a healthy WFH culture.
As for loneliness - a couple things help with that. First, get together in person for a week or so every quarter to link up. Second, you don't have to work from an office when you work remote. Third, working in the office starting out to understand the culture then going remote is helpful for networking / understanding the rhythm of those in the office if you do work with full-time office folks. Being within reach can be helpful but not required. I'm close enough to the office that I can go in for big meetings or in-person things without too much heads-up, but I'm not expected to be there, and I'm probably there once a month, max.
As for addiction - clearly you gotta prioritize to make sure that stuff doesn't destroy your life. If remote work doesn't work for you, definitely don't do it. Doesn't mean it's not magic for many of us.