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Progress of anti-aging therapies by clinical trial stage

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Re: Progress of anti-aging therapies by clinical trial stage

#131

Post by newnewpdro »

tomerico wrote: post #123
peanutz454 wrote: post #120

Earlier quoted context omitted.

So when it happens, will we stop having kids? Because our current population and lifestyle do not seem sustainable. I only see population increasing and lifestyle being more burdensome on environment.

Ironically, if people that care about the planet don’t have kids to save the planet, you will be left with more people that don’t care about the planet down the road

I don't know about you, but some of my teachers and favorite musicians had far more of an impact on my attitudes toward the environment and having children than my parents ever did.

This fallacy that the only way to fix the world is to make kids of your own that will make it better is ridiculous.

Re: Progress of anti-aging therapies by clinical trial stage

#132

Post by Karlozkiller »

xiphias2 wrote: post #40

While I'm taking NMN, as it's proven to be safe, I know that HGH + DHEA is the only drug from the list that has already proven to make healthy people younger. I'm seriously considering it in a few years after it has more time to be proven safe enough. For now I'm planning to measure DNA methylation in my body to understand the reason for my chronic illnesses better. I already got my DNA sequenced, but now that methyl…

HGH being Human Growth Hormone? I've taken that during puberty, as a medium to get to "normal size"

In hindsight doctors say that might have been what triggered my chronic auto immune hepatitis (immune system attacks my own liver). They say basically they don't know and will probably never know, but it has been put forth as a possible trigger.

Be careful.

Re: Progress of anti-aging therapies by clinical trial stage

#133

Post by iopq »

chrisco255 wrote: post #7
jcadam wrote: post #5

They need to hurry up with this, I'm not getting any younger and I haven't saved enough for retirement :O

Yeah but if they extend your life won't you need even more for retirement?

This is technically true, but once you plan for a 60 year retirement, going out 90 or 100 years is not as difficult as lasting the first 30 years.

I think withdrawing 3% a year would have lasted you the entire time since the 1880s (last 140 years of the stock market)

Re: Progress of anti-aging therapies by clinical trial stage

#134

Post by on_and_off »

on_and_off wrote: post #25
Japhy_Ryder wrote: post #23

Earlier quoted context omitted.

A vegan/plant-based diet and now we're talking! I like this list a lot!

Agree that eating meat at every meal is a dumb idea but is there much difference between a plant based diet and a mediterranean one in this regard ?

I guess not

Re: Progress of anti-aging therapies by clinical trial stage

#135

Post by Erlich_Bachman »

lawrenceyan wrote: post #68
Erlich_Bachman wrote: post #56

Earlier quoted context omitted.

This post is poorly researched or misguided relative to the topic at hand. We are discussing drugs(or other systemic measures or therapies) that make people younger. The only thing that you can manage to do if you do all those things you listed perfectly is to come close to your theoretical maximum lifespan that is already preset in your biology/genetics. What we are trying to do with these drugs is to increase that…

I'm sorry to disappoint you, drugs (defined by the simple macromolecules we know them to be today) can supplement your body in doing only what it is already capable of. Increasing lifespan more than that requires an entirely new paradigm or class of therapeutics. Like you said, we'll need entirely new biological/genetic technology to address the system-wide mutation and degradation of the body that inevitably occurs…

> can supplement your body in doing only what it is already capable of

Oh then I guess the body is perfectly capable of having lucid trips for hours like users report from a simple little molecule such as LSD. Good to know. /s

Re: Progress of anti-aging therapies by clinical trial stage

#136

Post by Erlich_Bachman »

dnhz wrote: post #88
staticassertion wrote: post #80

Earlier quoted context omitted.

> drugs (defined by the simple macromolecules we know them to be today) can supplement your body in doing only what it is already capable of. Lots of drugs do things that your body is not capable of, and many drugs augment the way your body works in a way that is not possible without an external compound.

I tend to think of aging as an overall degradation of the system. For instance, there’s loss of hair cells in the ear that reduces hearing higher frequencies. There’s clouding of the eye lens as the proteins there aggregate. Long lived cells like neurons accumulate oxidation and probably die at some slow rate. I can’t quite see how drugs which modulate existing biochemical pathways can stop, let alone reverse the pro…

> I tend to think of aging as an overall degradation of the system

Why do you do that? Why would you think it is correct?

To my knowledge that's a wrong interpretation.

Yes there is constant continuous damage to DNA and cells etc. But the body has mechanisms to repair that damage. It is the repairment that slows down during aging, and that is programmed by genetic and biological processes, like everything else in the body. Biologically, a cell can keep reproducing over and over again, it is no problem.

Re: Progress of anti-aging therapies by clinical trial stage

#137

Post by chrisco255 »

dpatrick86 wrote: post #101
xiphias2 wrote: post #40

While I'm taking NMN, as it's proven to be safe, I know that HGH + DHEA is the only drug from the list that has already proven to make healthy people younger. I'm seriously considering it in a few years after it has more time to be proven safe enough. For now I'm planning to measure DNA methylation in my body to understand the reason for my chronic illnesses better. I already got my DNA sequenced, but now that methyl…

What makes you think NMN has been "proven to be safe?" That's a pretty strong standard to conform to. There's virtually no clinical work that's been done at all, for starters. A lot of genuine promising research in animals, but you also have this animal cancer model that suggests at least a little caution... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448588/

NMN is a B-vitamin derivative.

Re: Progress of anti-aging therapies by clinical trial stage

#138

Post by chrisco255 »

JimboOmega wrote: post #95
xiphias2 wrote: post #40

While I'm taking NMN, as it's proven to be safe, I know that HGH + DHEA is the only drug from the list that has already proven to make healthy people younger. I'm seriously considering it in a few years after it has more time to be proven safe enough. For now I'm planning to measure DNA methylation in my body to understand the reason for my chronic illnesses better. I already got my DNA sequenced, but now that methyl…

What's the difference between NMN vs NR? I take NR and they're chemically similar and I thought both are sold as anti-aging?

It's been claimed by some that NR is less stable in the bloodstream and doesn't boost NAD+ levels as much as NMN.

Re: Progress of anti-aging therapies by clinical trial stage

#139

Post by thelittleone »

wrinkl3 wrote: post #89
lcnmrn wrote: post #87

Earlier quoted context omitted.

But it's not actually AI, it's just programmable probability.

Which is what modern AI is - neat linear algebra that can perform certain tasks that are commonly associated with human cognition.

How and when did this become the definition of AI? I feel like we techies lost an important distinction by simply accepting the marketing appropriation of the term. What do we now call real AI?

Re: Progress of anti-aging therapies by clinical trial stage

#140

Post by AstralStorm »

naasking wrote: post #103
crystaldev wrote: post #79

Earlier quoted context omitted.

Maybe it's that I'm mid-career and burnt out, but the idea of getting to be a draft animal for an extra decade is utterly unappealing.

Agreed, but keep in mind rejuvenation means it'd be a lot harder to get burnt out and easier to recover.

Feeling better about it does not change the fact that you're a draft animal.

(Not doing what you actually want to.)

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