I don't disagree in principle with the idea that the physical aspects of/influences on depression are worth studying.
I do, however, think the overall approach we are taking towards depression as a society is fundamentally backwards. We have a massive industry that is focused around producing psychiatric medication so that people can more effectively operate in the society we've structured around them, but we didn't even stop to consider the idea that maybe it is the systems we've built around them that are pathological in themselves.
We have this basic notion that if someone doesn't fit in with this social mold we've built that it must be a fault in them, it must be a sickness they suffer from that prevents them from thriving in the ways we expect them to. But why are we not asking ourselves whether the square hole that we are trying to shove their round peg into isn't the problem in itself? Why do we think we are helpless to change things on a systemic level? We grate against the idea that the world we've built might be a bad fit for us, and not the other way around.
Instead, we have pathologized what is an entirely natural reaction to the world people live in. We think we need medication to make humans fit better into this system, but really it is the system that is failing us. We built this world for us to live in, why did we make it so incredibly hostile to human happiness?