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Drugs that tamp down inflammation in the brain could slow cognitive decline

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Re: Drugs that tamp down inflammation in the brain could slow cognitive decline

#31

Chronic inflammation appears to be caused by persistent self-stimulation -- eating for comfort or pleasure, not getting enough sleep, chain-smoking, getting high, etc, without respite. So it's not really a biological problem. It's a widespread personal problem with complex biological consequences.

Can you cite your sources for that claim?

Re: Drugs that tamp down inflammation in the brain could slow cognitive decline

#32
post #5

From the perspective of a non-biologist reader only seeing popular articles, the past ten years have been completely bewildering. Nutrition has seemingly been boiled down to a couple of magic totems that are always simplistically either good or bad. Antioxidants are good. Inflammation is bad. Telomeres are good. Carbs are bad. All the "bad" things get associated with each other and anti-associated with the good thing…

> Nutrition has

-> Always been like this.

As a very smart bio professor once said to me: the half-life of a nutrition paper is about 2 years.

Re: Drugs that tamp down inflammation in the brain could slow cognitive decline

#34
post #5

From the perspective of a non-biologist reader only seeing popular articles, the past ten years have been completely bewildering. Nutrition has seemingly been boiled down to a couple of magic totems that are always simplistically either good or bad. Antioxidants are good. Inflammation is bad. Telomeres are good. Carbs are bad. All the "bad" things get associated with each other and anti-associated with the good thing…

[deleted]

Re: Drugs that tamp down inflammation in the brain could slow cognitive decline

#35

Chronic inflammation appears to be caused by persistent self-stimulation -- eating for comfort or pleasure, not getting enough sleep, chain-smoking, getting high, etc, without respite. So it's not really a biological problem. It's a widespread personal problem with complex biological consequences.

Can you cite your sources for that claim?

No, it's just the way it seems to me.

Re: Drugs that tamp down inflammation in the brain could slow cognitive decline

#37

Chronic inflammation appears to be caused by persistent self-stimulation -- eating for comfort or pleasure, not getting enough sleep, chain-smoking, getting high, etc, without respite. So it's not really a biological problem. It's a widespread personal problem with complex biological consequences.

Even if chronic inflammation was caused by self-stimulation, that still makes it a biological problem. Maybe you meant it wasn't an inherent, biological part of aging? If that's what you meant, then I still don't agree.

IMHO, the biggest contributor to chronic inflammation is the Standard American Diet (lots of grains and refined foods) combined with a lack of exercise. These things have a greater, compounding effect with age. You can't exactly tell an 80 year old woman to start running or lift weights on a daily basis.

Re: Drugs that tamp down inflammation in the brain could slow cognitive decline

#38
post #27

Wouldn't it be better and more effective to treat the cause of the inflammation instead?

Maybe, but what's the plan to do that?

Occasional fasting, diet, exercise, sleep, positive relationships.

Re: Drugs that tamp down inflammation in the brain could slow cognitive decline

#39
post #6

Alternatively, you can quite dramatically reduce inflammation in the brain via some simple lifestyle modifications (cutting out sugar, intermittent fasting): Mattson, Mark P., Keelin Moehl, Nathaniel Ghena, Maggie Schmaedick, and Aiwu Cheng. “Intermittent Metabolic Switching, Neuroplasticity and Brain Health.” Nature Reviews. Neuroscience 19, no. 2 (February 2018): 63–80. https://doi.org/10.1038/nrn.2017.156 . Pinto,…

Have any of these studies been reproduced?

Re: Drugs that tamp down inflammation in the brain could slow cognitive decline

#40
post #30

Chronic inflammation appears to be caused by persistent self-stimulation -- eating for comfort or pleasure, not getting enough sleep, chain-smoking, getting high, etc, without respite. So it's not really a biological problem. It's a widespread personal problem with complex biological consequences.

can you expand this concept?

Not much because it's quite nebulous. It does seem to make scientific sense that the body would reduce such defences to bare essentials like inflammation and blood clotting during crisis in order to save energy. These systems would normally come fully back online during 'rest and digest' periods when the short-term crisis is over. Why do people enjoy chronic activation of the sympathetic nervous system? I think it's a form of distraction: a way of avoiding boredom or the contemplation of painful memories and personal problems. This is common sense for many people but it obviously isn't being addressed by the harder biological and medical journals because they don't like to talk about subjective experiences. Presumably because they require objectivity and they think of subjectivity as being the opposite. But this is itself a misconception:

https://twitter.com/DavidDeutschOxf/status/11746303659123261...

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