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Longevity Linked to Proteins That Calm Overexcited Neurons

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Re: Longevity Linked to Proteins That Calm Overexcited Neurons

#41
post #2

Could this be related to the generally shorter lifespans of males?

Life expectancy was the same for both genders in 1900 (in Europe at least). We’ve just made continually more progress for women than for men. Nowadays for example: lots of research on female cancer (twice more funding than male cancers, for the same incidence and mortality) and domestic violence, little budgets on suicide. Lots of money for equality at work where women are fewer, little money for boys massively dropp…

Sad facts.

Re: Longevity Linked to Proteins That Calm Overexcited Neurons

#43

Earlier quoted context omitted.

Life expectancy was the same for both genders in 1900 (in Europe at least). We’ve just made continually more progress for women than for men. Nowadays for example: lots of research on female cancer (twice more funding than male cancers, for the same incidence and mortality) and domestic violence, little budgets on suicide. Lots of money for equality at work where women are fewer, little money for boys massively dropp…

You are driving a thesis here but using only data which supports that thesis. There are many other reasons why, at least in the culture I'm familiar with (the USA) men have tended to live shorter. These are all stated in past tense, though many are still true today: - men smoked at higher rates than women - men were more likely to drink heavily - men were more likely to engage in dangerous work (construction vs nursi…

Lets take this from a perspective of stress. Stress is highly correlated with life length, with those who has good stress management having longer lifer. What is good stress management? Among other things good social support. Bad stress management is things like substance abuse.

So why do men have worse social support than women? First we can look at is how society reward men who focus their time on social networking compared to a focus on career and higher income. On average, how do society react if a man choose a high social job such as nursing vs a high income job such as construction, and then compare that average for women.

The second thing we can look at is a more obvious one. On average men are more likely to be childless than women. It should surprise no one that having one or more children does increase the probability of a social support network at old age.

The third thing is suicide which is the single largest cause of death for men until age of 65 (if I remember right). Suicide is highly correlated with untreated depression, a illness where it is well know that men is in the receive end of discrimination. Very few culture has any tolerance for men with mental illness, and this again is correlated to social support and in the long run stress management. Men with mental illness run higher risk of handling it alone compared to women.

It should be noted here that for the age groups where "drive aggressively and/or drive motorcycles" is relevant, suicide is still more common cause of death. I will also include the age groups of people who say "watch this".

Re: Longevity Linked to Proteins That Calm Overexcited Neurons

#44
post #25

I’m suspicious of the bacronym REST. Was it created to push the idea? I’d rather they coined a neutral acronym. This one reeks of marketing.

I'm sure it wasn't an accident, but I think it was just meant to be a convenient association with it having an inhibitory effect.

At least it's not as overloaded as SAD.

Re: Longevity Linked to Proteins That Calm Overexcited Neurons

#45
post #14

Does this relate in any way to the anti-aging drug cocktail that we saw a few months ago? IIRC that one related to genetic aging markers, and stress can affect mitosis. It seems like immortality has a lot of building blocks, and the research isn't far enough to combine them yet.

Here is the Nature article with a link to the study in the footnotes.

https://www.nature.com/articles/d41586-019-02638-w

This blog post has commentary on the study. If you are interested in the topic, consider suspending disbelief until after reading the post. It does a great job of clarifying what the evidence actually shows, and outlines one way to contextualize this intervention.

http://haidut.me/?p=546

Re: Longevity Linked to Proteins That Calm Overexcited Neurons

#46

Earlier quoted context omitted.

There are some interesting challenges to your premise, even though some of it very clearly plays a role in the gap. There is a six year gap (81 vs 87 as of 2018-2019) between men and women in Japan. Arguably none of that gap is properly explained by the issues you've raised. The Japanese are the healthiest, longest living people of any large cohort on the planet and yet the gap persists. Further, roughly twice as man…

There’s a theory that longevity is lower in men because they need to be stronger in order to survive in a conflict. It’s a trade off. Physical strength is the result of growth, but some of the same pathways for increased growth are also theorized to be the root cause of aging. Note that this is independent of strength training; it’s the ability to get stronger, rather than actually getting stronger (among other relat…

More muscles are correlated with lower incidence of cancer (and inflammation), so that goes against strength preference being a reason of aging.

Re: Longevity Linked to Proteins That Calm Overexcited Neurons

#47

> In their new study, Yankner and his colleagues report that the brains of long-lived humans have unusually low levels of proteins involved in excitation, at least in comparison with the brains of people who died much younger. This finding suggests that the exceptionally old people probably had less neural firing. To investigate this association in more detail, Yankner’s team turned to C. elegans. They compared neura…

Depends on the nature of activity. Pure stress will activate your brain but experience is mostly degraded.

And having everything firing at once is a seizure. But somewhere between that and normal is unclear.

It's also possible the association is in the other direction - people with neurons that fire less might be less stressed in general (almost by definition), and maybe the effect of stress on longevity takes place elsewhere entirely.

Re: Longevity Linked to Proteins That Calm Overexcited Neurons

#49

Earlier quoted context omitted.

I know that your points are standard masculinist talking points and I most probably won’t change your perspective. As I understand it, you seem to point the blame for men relatively shorter lifespan (which in fact have consistently grow over the last decades in OCDE countries, except in the US) toward “more attention to women’s issues”. Of course every single bit of attention to women’s issues have been a very long h…

Raise men as girls? What good parent doesnt try and raise there sons do have care and empathy and to be reasonable? Are there any positive traits that you think men possess? You are only taking the negative side of mens tendency for risk taking. Willingness to take risks has many positive benefits like getting to the top management spots you mentioned.

A few points:

- Here's a recent example[1] of a father who doesn't seem to raise his sons with empathy and reason as his core value. He explicitly state that this is in opposition of "raising boys like girls"[2]. It's an over-the-top example, but of course every time an adult encourage a boy to bottle up his emotions, to be stronger than the other boys, to go and force-kiss a little girl, etc. they reinforce this construct a bit.

[1] https://twitter.com/aubrey_huff/status/1199200986658553857 [2] https://twitter.com/aubrey_huff/status/1200543836700889090

- Women contribute vastly more than men to the fundamental care that keep society going via mostly invisible, unpaid but constant and demanding work (see the documentary "Who's Counting? Marilyn Waring on Sex, Lies and Global Economics" for an accessible intro to that [3]. Example are child rearing, elderly care, domestic chores, generally taking care of social organizing... Men mostly opt out of this work, and we should not let them. We should teach boys to take an active part in this. That's another way to raise boys as girls.

[3] https://www.onf.ca/film/whos_counting/

- Are you sure that dangerous behaviors like drunk driving or bar fights are a necessary component of learning how to become a brilliant top manager? I have my doubts. In any case, it's a cultural decision: do we continue to encourage young men to be reckless and let them die more often than women of violent death, because being reckless will also help them steal all the good spots? If this kind of risk taking is so beneficial, do we encourage girls to be reckless too? Or do we encourage a more peaceful culture for boys?

(Anyway, your point about risk taking is conflating different kind of risks. Launching a startup or managing a big co has nothing to do with jumping off of a bridge because your friends dare you to do it.)

- Do I find some traditionally male traits desirable? Yes, a few of the less toxic. I think girls should be raised and socially accepted to be much less self-diminishing. To easily talk in public with confidence. To recognize their own physical force as it is and not less. To assert their own desires and to not default to fulfill the desires of their partners as a priority.

So I'm one of these persons who think that erasing the gender lines as much as possible would be beneficial for our societies :-)

Re: Longevity Linked to Proteins That Calm Overexcited Neurons

#50

Earlier quoted context omitted.

Raise men as girls? What good parent doesnt try and raise there sons do have care and empathy and to be reasonable? Are there any positive traits that you think men possess? You are only taking the negative side of mens tendency for risk taking. Willingness to take risks has many positive benefits like getting to the top management spots you mentioned.

A few points: - Here's a recent example[1] of a father who doesn't seem to raise his sons with empathy and reason as his core value. He explicitly state that this is in opposition of "raising boys like girls"[2]. It's an over-the-top example, but of course every time an adult encourage a boy to bottle up his emotions, to be stronger than the other boys, to go and force-kiss a little girl, etc. they reinforce this con…

Im not sure what your first point is attempting to accomplish. I said good parents and you are always going to be able to find one off exceptions and people who have seemingly wonky ideas about child rearing. A good parent on average will try and instill those good characteristics you mentioned in all their children whether boys or girls.

If your trying to say that the home care that more traditional or conservative women engage in is fundamental to society than I agree. So why do you want to push women to less fundamental roles in society?

You seem to only few attributes that are traditionally ascribed to men in a negative light. I dont think that bar fights or any other negative activity are necessary that is why men should use their natural tendencies in a good and productive manner as well as should women.

All of the 'positive' traits that you listed have an underlying negative connotation. Assert their own desires, Easily talk in public are not fundamental traits. Im not sure what you mean by 'use their own physical force'. It looks like you view men as mostly toxic.

So you think that men and women should be as indistinguishable from one another as possible? I am one of those people who celebrate diversity by realizing that the differences among genders and cultures ect.. are what makes life interesting.

By erasing gender lines you seem to mean erasing men and making them women. Wouldn't it be healthier for both genders to express their natural attributes in a positive way?

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