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Longevity Linked to Proteins That Calm Overexcited Neurons

quantamagazine.org

21–30 of 59 posts

Re: Longevity Linked to Proteins That Calm Overexcited Neurons

#21
post #15

Earlier quoted context omitted.

Depends on the nature of activity. Pure stress will activate your brain but experience is mostly degraded.

What if stressful existance pushes for shorter lifespan with the effect of quickening the turnover of generations. So stressful environment would speed up the evolutionary iteration of generations. While less stressful existance that has adopted to the environment would persist longer.

This analogy happens in some animals for sure. At the zoo they place the antelope near the cheetahs so that they breed more.

Re: Longevity Linked to Proteins That Calm Overexcited Neurons

#22
post #2

Could this be related to the generally shorter lifespans of males?

Life expectancy was the same for both genders in 1900 (in Europe at least). We’ve just made continually more progress for women than for men. Nowadays for example: lots of research on female cancer (twice more funding than male cancers, for the same incidence and mortality) and domestic violence, little budgets on suicide. Lots of money for equality at work where women are fewer, little money for boys massively dropp…

I know that your points are standard masculinist talking points and I most probably won’t change your perspective.

As I understand it, you seem to point the blame for men relatively shorter lifespan (which in fact have consistently grow over the last decades in OCDE countries, except in the US) toward “more attention to women’s issues”.

Of course every single bit of attention to women’s issues have been a very long hard fight (for example thousands of women were dying each year of illegal abortion, for decades and centuries… that was not an easy fight to get this fixed, because men in charge couldn’t care less.)

But, hey, here’s are four points —in addition to the statistics others have pointed out— that paint a different picture than the “men have been abandoned” framing:

- Young men takes more risks and die more frequently of violent death (road accident for example, or alcool related accident in general). That’s a social posture that feminism is actively trying to change but strangely this is cherished by many men, who think changing the male culture is somehow bad for them. If we want young men to die less, let’s raise them as girls (I’m 100% serious). If you actively refuse to raise boys with girly values like care and empathy and being reasonable, then you are actively encouraging young men to risk their life in various stupid ways.

- Women health have been second to men health in many domains since a very long time. One reason has been under diagnosis (ex: cardiac issues used to be under diagnosed for women, might still be the case). Women are under diagnosed because doctors tend to think they are exaggerating their symptoms. This have been document by medical studies, for example in Canada, where they had relatively to the number of cases more death of cardiac complications for women than for men.

- You are right that more boys drop out of school. Again, several gender issues researchers have pointed that trend back in the 80s or 90s. I believe feminists were the first to alert on that trend (in any case, I first read about it in feminist publications). Yet, incredibly, men overall have a bigger share of total wages and occupy the top management seat and most of gouvernement seats in OCDE. Go figure! Maybe men are favorited after all?

- Back to medical research. Did you know that female subjects have been traditionally excluded from medical research when creating test group? It is called the medical gender gap, and has been documented and, of course, people have been trying actively to reverse it since the 90s because it is harmful for women.

Sorry if these 4 points might seem disjointed. But if you want to learn more, they might be a start for you. Dig and read feminist research.

Re: Longevity Linked to Proteins That Calm Overexcited Neurons

#23

Earlier quoted context omitted.

Life expectancy was the same for both genders in 1900 (in Europe at least). We’ve just made continually more progress for women than for men. Nowadays for example: lots of research on female cancer (twice more funding than male cancers, for the same incidence and mortality) and domestic violence, little budgets on suicide. Lots of money for equality at work where women are fewer, little money for boys massively dropp…

There are some interesting challenges to your premise, even though some of it very clearly plays a role in the gap. There is a six year gap (81 vs 87 as of 2018-2019) between men and women in Japan. Arguably none of that gap is properly explained by the issues you've raised. The Japanese are the healthiest, longest living people of any large cohort on the planet and yet the gap persists. Further, roughly twice as man…

There’s a theory that longevity is lower in men because they need to be stronger in order to survive in a conflict. It’s a trade off. Physical strength is the result of growth, but some of the same pathways for increased growth are also theorized to be the root cause of aging. Note that this is independent of strength training; it’s the ability to get stronger, rather than actually getting stronger (among other related characteristics), that may affect longevity. Your intuition that accidental death and smoking do not explain the entirety of the gender gap in longevity is spot on. It’s not all bad news for men though. If you manage to avoid obesity and diabetes, your increased strength and bone density may impart greater quality of life in old age, and that may be worth the 3 lost years at the end of life. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034172/

Re: Longevity Linked to Proteins That Calm Overexcited Neurons

#26
post #25

I’m suspicious of the bacronym REST. Was it created to push the idea? I’d rather they coined a neutral acronym. This one reeks of marketing.

Everyone knows you come up with the cool acronym first and then figure out what the letters mean to fit the cool acronym.

Re: Longevity Linked to Proteins That Calm Overexcited Neurons

#27

Earlier quoted context omitted.

Life expectancy was the same for both genders in 1900 (in Europe at least). We’ve just made continually more progress for women than for men. Nowadays for example: lots of research on female cancer (twice more funding than male cancers, for the same incidence and mortality) and domestic violence, little budgets on suicide. Lots of money for equality at work where women are fewer, little money for boys massively dropp…

There are some interesting challenges to your premise, even though some of it very clearly plays a role in the gap. There is a six year gap (81 vs 87 as of 2018-2019) between men and women in Japan. Arguably none of that gap is properly explained by the issues you've raised. The Japanese are the healthiest, longest living people of any large cohort on the planet and yet the gap persists. Further, roughly twice as man…

The Japan difference for life expectancy could just be because Japanese men work themselves to death more often than not. Women do as well, but there's also lots of pressure to get them out of the workforce.

Re: Longevity Linked to Proteins That Calm Overexcited Neurons

#28
post #25

I’m suspicious of the bacronym REST. Was it created to push the idea? I’d rather they coined a neutral acronym. This one reeks of marketing.

That's a rather strong accusation...

In the article it says REST was studied previously in contexts that have nothing to do with aging.

Re: Longevity Linked to Proteins That Calm Overexcited Neurons

#29

Earlier quoted context omitted.

Life expectancy was the same for both genders in 1900 (in Europe at least). We’ve just made continually more progress for women than for men. Nowadays for example: lots of research on female cancer (twice more funding than male cancers, for the same incidence and mortality) and domestic violence, little budgets on suicide. Lots of money for equality at work where women are fewer, little money for boys massively dropp…

I know that your points are standard masculinist talking points and I most probably won’t change your perspective. As I understand it, you seem to point the blame for men relatively shorter lifespan (which in fact have consistently grow over the last decades in OCDE countries, except in the US) toward “more attention to women’s issues”. Of course every single bit of attention to women’s issues have been a very long h…

> Young men takes more risks and die more frequently of violent death (road accident for example, or alcool related accident in general). That’s a social posture that feminism is actively trying to change but strangely this is cherished by many men, who think changing the male culture is somehow bad for them. If we want young men to die less, let’s raise them as girls (I’m 100% serious). If you actively refuse to raise boys with girly values like care and empathy and being reasonable, then you are actively encouraging young men to risk their life in various stupid ways.

Straw man argument. Reckless impulsive unreflective behaviour is not uniquely masculine or male, it is immature. Men and women are immature and reckless in different ways.

Re: Longevity Linked to Proteins That Calm Overexcited Neurons

#30

Earlier quoted context omitted.

There are some interesting challenges to your premise, even though some of it very clearly plays a role in the gap. There is a six year gap (81 vs 87 as of 2018-2019) between men and women in Japan. Arguably none of that gap is properly explained by the issues you've raised. The Japanese are the healthiest, longest living people of any large cohort on the planet and yet the gap persists. Further, roughly twice as man…

There’s a theory that longevity is lower in men because they need to be stronger in order to survive in a conflict. It’s a trade off. Physical strength is the result of growth, but some of the same pathways for increased growth are also theorized to be the root cause of aging. Note that this is independent of strength training; it’s the ability to get stronger, rather than actually getting stronger (among other relat…

The big killer among modern elderly people is the massive muscle wasting that accompanies most inpatient hospital procedures. Having a solid foundation of muscle can insulate a person from the dreaded point of no return after which it would be impossible to build one's body back after a procedure.
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