Some 8 years or so ago I experimented with triggering mood changes using a meditative technique. I had long been doing 'centering' meditative exercises so that I could bring more focus and clarity to seated practice. I wanted something more practical that would affect my everyday life. I eventually settled on two 'states'. A 'centered' state and a 'joyful' one. Any time I noticed myself outside of one of the two stat…
I was living in a state of bliss I could turn up and down for years. I could turn it up so high I'd pass out from it.
After years of this, something happened and I stopped being able to feel bliss at all. It was like a part of my neurology had been fried. I assumed it was something I had done so I turned to suttas to try to figure out what was up, assuming it was a meditation problem. I learned Buddhism, I solved my psychological problems, even ended suffering, but at the end of the day the bliss was gone never to come back.
Doctors call it depression, but I'm optimistic and enjoy life. They may have never bumped into anyone like me before.
At the end of the day I'm grateful for the experiences I've had, but if you live high as a kite for years, you can OD on it. I imagine someone who ODs on a benzo or meth might have a similar experience.