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Starving cancer by cutting off its favorite foods

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Re: Starving cancer by cutting off its favorite foods

#121

Earlier quoted context omitted.

> I feel like this is sufficient to refute your several oncologists' anecdotal opinions which are not supported by the research. It's not. Unless you have the appropriate training and experience, you are not capable of making treatment recommendations. Sorry if that seems harsh, but this is not something you can just Google your way through. This is not one of those things where you can find the hidden truth by readi…

You appear to be falling victim to: https://en.wikipedia.org/wiki/Argument_from_authority The research clearly indicates that there is a benefit to fasting, yet you say the research is wrong because of the opinions of several oncologists. I'm biased because several oncologists told me something that wasn't true.

Medical research is an inductive endeavor; avoiding deductive fallacies won't help you much.

You have to distinguish between these two statements:

a) There is research that indicates that there is a benefit to fasting

b) The research indicates that there is a benefit to fasting

Statement a) is true; but b) is what you said.

Going from a) to b) is the hard part. It's not enough to know what some research says, you need to place it within the broader context of the field of knowledge before you can make declarative statements of benefit. And cancer is an incredibly complex and fast-moving field of knowledge.

The oncologists I spoke with were aware of research into voluntary fasting, but on balance recommended against it. One reason is that unlike with a healthy person, ending the fast may not be under the patient's control, depending on how they tolerate their chemotherapy. Chemotherapy ends up looking like intermittent fasting for a lot of patients anyway.

Chemotherapy is also cumulative, which means that decisions that appear beneficial in early rounds may end up limiting the total number of sequential rounds that a patient can tolerate.

If someone is not habitually fasting, adding it on top of chemotherapy adds a significant confounding factor to a process that is already hard to predict.

And aside from voluntary fasting, there is a lot of evidence that patients who can eat well and keep their weight up have better outcomes from chemotherapy than those who can't/won't eat and lose weight.

This is what I was told by people who spend their lives studying the treatment of cancer.

Re: Starving cancer by cutting off its favorite foods

#122
post #6

> your body closely regulates the level of glucose in your blood. Your brain would literally starve without it. Is this actually true? Having done the ketogenic diet and bringing carbohydrates down to almost nothing, my brain definitely didn't starve. In fact, running on ketones was amazing.

The amount of carbohydrates you need in your diet to survive is exactly zero. They’re a non-essential macronutrient. The amount of glucose you need in your blood stream to keep everything running smoothly is a very small amount easily produced by your body through a process called gluconeogenesis. I went 60 days sans any calories and my body self regulated glucose just fine.

How did you kickstart the fast? I find the first 4-5 days are pretty tough. At what point did it become easy?

Were you working during this period or off work? Sometimes starting the fast is troublesome when one knows there's going to be energy level issues.

I like the idea of avoiding coffee/tea, that's something I think could help in the long run.

Re: Starving cancer by cutting off its favorite foods

#123

Earlier quoted context omitted.

What did you finally eat to beak your fast?

Uhh, I have a log of that somewhere one second... This is day 61, I'd estimate like 4k-ish calories. 07:51 - Woke to Alarm 08:34 - Weight 199.8 - Bodyfat 26.1 08:41 - Start First Meal - Handful of Spinach Wilted in 2 tbsp Butter - 5 Olives - 1 Dill Pickle Spear - 6 oz Pickle Juice 08:45 - End First Meal 08:50 - Drank 1/2 Liter Water 08:57 - Start Sauna 165.0 F 09:00 - Drank 1 Liter Water 09:12 - End Sauna 182.5 F 09:…

How are you typically making your log? shell script?

Did your stomach not get upset with you the following day?

Most people break their fast with something really easy to digest like pickle juice etc.

Re: Starving cancer by cutting off its favorite foods

#124

Earlier quoted context omitted.

What did you finally eat to beak your fast?

Uhh, I have a log of that somewhere one second... This is day 61, I'd estimate like 4k-ish calories. 07:51 - Woke to Alarm 08:34 - Weight 199.8 - Bodyfat 26.1 08:41 - Start First Meal - Handful of Spinach Wilted in 2 tbsp Butter - 5 Olives - 1 Dill Pickle Spear - 6 oz Pickle Juice 08:45 - End First Meal 08:50 - Drank 1/2 Liter Water 08:57 - Start Sauna 165.0 F 09:00 - Drank 1 Liter Water 09:12 - End Sauna 182.5 F 09:…

You fasted for 60 days and the first thing you ate to break your fast was... spinach? You have next-level willpower.

Re: Starving cancer by cutting off its favorite foods

#125

Earlier quoted context omitted.

You appear to be falling victim to: https://en.wikipedia.org/wiki/Argument_from_authority The research clearly indicates that there is a benefit to fasting, yet you say the research is wrong because of the opinions of several oncologists. I'm biased because several oncologists told me something that wasn't true.

Medical research is an inductive endeavor; avoiding deductive fallacies won't help you much. You have to distinguish between these two statements: a) There is research that indicates that there is a benefit to fasting b) The research indicates that there is a benefit to fasting Statement a) is true; but b) is what you said. Going from a) to b) is the hard part. It's not enough to know what some research says, you nee…

I made a statement derived from lots of research I have personally done. You said I was wrong. I provided evidence of the research. You provided ... none.

You said I was "dangerously wrong" because someone else you talked to said I was wrong, but you have provided no evidence supporting your case, other than hearsay.

I have provided evidence. You concluded with:

> This is what I was told by people who spend their lives studying the treatment of cancer.

Which, again, is appeal to authority. It's a logical fallacy.

How much evidence do I need to provide? https://www.cancertherapyadvisor.com/home/tools/fact-sheets/...

> Current data in humans suggests that IF may be beneficial for chemotherapy outcomes, particularly for reducing toxicities. IF appears to be safe in appropriately selected patients, and the adverse effects associated with fasting appear to all be of low grade.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530042/

> Growing preclinical evidence shows that short-term fasting (STF) protects from toxicity while enhancing the efficacy of a variety of chemotherapeutic agents in the treatment of various tumour types. STF reinforces stress resistance of healthy cells, while tumor cells become even more sensitive to toxins, perhaps through shortage of nutrients to satisfy their needs in the context of high proliferation rates and/or loss of flexibility to respond to extreme circumstances.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031958/

> Both chronic calorie restriction (CCR) and intermittent calorie restriction (ICR) have shown anticancer effects.

https://www.cell.com/trends/endocrinology-metabolism/fulltex...

> Fasting and FMDs have the potential for applications in both cancer prevention and treatment.

Do you have any evidence that fasting is deleterious to the health of cancer patients? Except what you said someone said?

Did you ask those oncologists for any evidence supporting their case or did you just take their words at face value?

Re: Starving cancer by cutting off its favorite foods

#126
post #88
post #68

Cancer favoring glucose has been known for a very long time, this is called the Warburg Effect: https://en.wikipedia.org/wiki/Warburg_effect_(oncology) Interesting new pharmacology for sure, but the end of the article is critical here: "Additionally, an accompanying commentary by William Katt and colleagues indicated that there are no FDA-approved drugs that target glucose and glutamine metabolism. This is because pr…

I worked on this for multiple myeloma. DCA is nice but the concentrations you need for treating people gives them peripheral neuropathy, which isn’t trivial. But fwiw combining DCA with other drugs looks promising. The issue is that cancer is polyclonal so there is a sub-population that predominantly relies of aerobic glycolysis, but the sub-populations that mostly metabolise glutamine or fatty acids will escape trea…

That makes sense. I think most people underappreciate how polyclonal cancer is. Every tumor isn't one cell, it's dozens or hundreds of different types of cell, which makes it extremely hard to cover all the possible escape paths for the cancer overall. As you mention, going with a shotgun approach of different drugs can help, but that's when toxicity becomes a real problem. It's not always possible to just give 2 drugs because one is so toxic on its own so you might kill the patient. One of the theories I've heard about why we've made relatively more progress on cancers in children is that they "heal" better, which means they can actually tolerate higher doses for some of these drugs.

Re: Starving cancer by cutting off its favorite foods

#127

Earlier quoted context omitted.

You appear to be falling victim to: https://en.wikipedia.org/wiki/Argument_from_authority The research clearly indicates that there is a benefit to fasting, yet you say the research is wrong because of the opinions of several oncologists. I'm biased because several oncologists told me something that wasn't true.

Medical research is an inductive endeavor; avoiding deductive fallacies won't help you much. You have to distinguish between these two statements: a) There is research that indicates that there is a benefit to fasting b) The research indicates that there is a benefit to fasting Statement a) is true; but b) is what you said. Going from a) to b) is the hard part. It's not enough to know what some research says, you nee…

> One reason is that unlike with a healthy person, ending the fast may not be under the patient's control, depending on how they tolerate their chemotherapy. Chemotherapy ends up looking like intermittent fasting for a lot of patients anyway.

It sounds like you are saying that the right answer depends on an individual's circumstances. I would agree. Certainly fasting could be harmful for some people depending upon their overall medical situation.

> If someone is not habitually fasting, adding it on top of chemotherapy adds a significant confounding factor to a process that is already hard to predict.

For my situation, the clinical evidence I could find suggested that chemotherapy does not have a statistically significant impact on the probability of disease-free survival. Even the oncologists who are recommending chemotherapy have been reluctant to claim it would necessarily be beneficial. This increased my interest in adding the significant confounding factor of fasting. In fact, you could say that I've been actively seeking significant confounding factors as the default path is rather dark.

As you noted, cancer is an incredibly complex and fast-moving field of knowledge. Given the currently limited research into the impact of fasting, I decided to conclude that maybe it can be helpful (especially since the biological hypotheses made some sense to my primitively educated mind).

Returning to your earlier point, I'm not sure it's currently possible to make a blanket claim of fasting being good or bad with respect to its impact on cancer patients. It seems that it would depend upon the patient's individual situation and priorities.

Re: Starving cancer by cutting off its favorite foods

#128
post #48

Earlier quoted context omitted.

I'd like to comment that you are wrong, but in the spirit of discussion; can you cite or link to sources for your claim, from within the past decade?

Sure, https://www.acsh.org/news/2019/10/02/starving-cancer-cutting...

Cheeky.

Re: Starving cancer by cutting off its favorite foods

#129
post #127

Earlier quoted context omitted.

Medical research is an inductive endeavor; avoiding deductive fallacies won't help you much. You have to distinguish between these two statements: a) There is research that indicates that there is a benefit to fasting b) The research indicates that there is a benefit to fasting Statement a) is true; but b) is what you said. Going from a) to b) is the hard part. It's not enough to know what some research says, you nee…

> One reason is that unlike with a healthy person, ending the fast may not be under the patient's control, depending on how they tolerate their chemotherapy. Chemotherapy ends up looking like intermittent fasting for a lot of patients anyway. It sounds like you are saying that the right answer depends on an individual's circumstances. I would agree. Certainly fasting could be harmful for some people depending upon th…

I agree that each course of treatment depends on each patient's individual situation and priorities. And I absolutely believe that each patient has the right to decide their own treatment when facing such a serious diagnosis.

What I object to is someone without medical training reading a few articles online and then posting universal declarations that fasting is good for everyone on chemo, and that people shouldn't trust oncologists for some reason. Obviously that's not you.

Re: Starving cancer by cutting off its favorite foods

#130
post #6

> your body closely regulates the level of glucose in your blood. Your brain would literally starve without it. Is this actually true? Having done the ketogenic diet and bringing carbohydrates down to almost nothing, my brain definitely didn't starve. In fact, running on ketones was amazing.

In the diet you describe the body would preferentially reserve all glucose for the brain and run the rest on ketones. The body can manufacture glucose when needed from other energy sources but it’s an energy intensive biochemical process and not ideal for efficient use of available nutrients.

  the body would preferentially reserve all glucose for the brain
No, because the brain can use ketone bodies as fuel. Some other organs (such as the heart) cannot.
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