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The Fugate family of Kentucky has had blue skin for centuries

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51–60 of 93 posts

Re: The Fugate family of Kentucky has had blue skin for centuries

#51
post #33

Earlier quoted context omitted.

> 50% of the children will be strictly superior (carriers) Is that domain nomenclature? Because I wouldn't call having to be careful who procreate with otherwise risk losing 25% of my children from that relationship as "strictly superior"...

2/4 resistant to malaria with no side effects and 1/4 dying is much much better than 4/4 dying from malaria

pretty good considering something like half of all human beings who ever lived died of Malaria!

Re: The Fugate family of Kentucky has had blue skin for centuries

#52
post #3

Is this article a carnival sideshow? " had that caused " I get it, we like to look at situations where people are different, but does this actually inform, educate, or improve us by reading? Or is this article just a chance to point out some people who are different. I've been thinking about this recently, and trying to moderate my curiosity (because blue skin certainly piques my curiosity) against what I'm trying to…

Most simply, you should now have ready example of a recessive phenotype, "Fugate Blue", that will allow you to immediately understand how all other recessive genetic diseases work.

Further, this is an example of a rare genetic disease, of which there are thousands. However, instead of needing an expensive research project to find a cure, a simple off the shelf chemical will do. So if you are ever reading about "Orphan Drugs", you'll also have an example of a successfully treated rare genetic disease!

Re: The Fugate family of Kentucky has had blue skin for centuries

#53

Methemoglobinemia seems to be a popular medical topic lately. It's an easily treatable disease, usually methylene blue is used, and it's more an inconvenience than anything else.

I don’t know if I’d call the inability for your blood to transport oxygen merely inconvenient.

Re: The Fugate family of Kentucky has had blue skin for centuries

#55

Earlier quoted context omitted.

2/4 resistant to malaria with no side effects and 1/4 dying is much much better than 4/4 dying from malaria

pretty good considering something like half of all human beings who ever lived died of Malaria!

I am mildly disappointed to learn that this is probably an overestimate, although it is pretty significant http://factmyth.com/factoids/malaria-killed-half-the-people-...

Re: The Fugate family of Kentucky has had blue skin for centuries

#56
post #54

Are we going to talk about the absolutely ridiculous amount of ads in this article?

Apparently I want to buy a blue sedan and I shouldn't make the 5 mistakes they list.

I wonder if someone is spinning me to finally take my driver's license.

Re: The Fugate family of Kentucky has had blue skin for centuries

#57
> The Blue Fugates are shown in this colorized black and white photo. Date unspecified. Original source unknown, via ABC News

It’s somewhat dishonest to illustrate an article on color with a photo that was colorized by someone we don’t know at an unknow date-- i.e. we don’t know anything about how they decided which shade of blue to apply on their faces. So the only interesting information caried by the photo, the shade of the blue color, has no source.

Also, this appears to be largely copied from this ABC News article: https://abcnews.go.com/Health/blue-skinned-people-kentucky-r...

Re: The Fugate family of Kentucky has had blue skin for centuries

#58
post #2

A fascinating article, but it's a bit frustrating that there are no colour photos. I tried searching the internet and found photos of other blue-skinned people but none of them had this genetic cause (mostly it was silver "supplements").

The internet seems to suggest this is Luna Fugate:

https://cdn.mutually.com/wp-content/uploads/2017/10/2-9.jpg

If so, according to the family tree, this would be the last homozygous member of the Fugate family.

Re: The Fugate family of Kentucky has had blue skin for centuries

#59
post #2

A fascinating article, but it's a bit frustrating that there are no colour photos. I tried searching the internet and found photos of other blue-skinned people but none of them had this genetic cause (mostly it was silver "supplements").

There's photos out there if you google for "autosomal recessive methemoglobinemia" -- for instance "Papa Smurf" [1] I just think it's super cool if you administer methylene blue dye, they turn back to normal within a half hour.

[1] https://abcnews.go.com/Health/internet-sensation-papa-smurf-...

Re: The Fugate family of Kentucky has had blue skin for centuries

#60
post #2

A fascinating article, but it's a bit frustrating that there are no colour photos. I tried searching the internet and found photos of other blue-skinned people but none of them had this genetic cause (mostly it was silver "supplements").

There's photos out there if you google for "autosomal recessive methemoglobinemia" -- for instance "Papa Smurf" [1] I just think it's super cool if you administer methylene blue dye, they turn back to normal within a half hour. [1] https://abcnews.go.com/Health/internet-sensation-papa-smurf-...

You are mixing up 2 things. Paul Karason had a syndrome called 'argyria' from dietary supplements. The article you link mentions that.

The Fugate family has the methemoglobinemia condition. They can be 'cured' with methylene blue. The former could not.

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