Effect of High-Dose Vitamin D on Volumetric Bone Density and Bone Strength • Hacker News Board

Re: Effect of High-Dose Vitamin D on Volumetric Bone Density and Bone Strength

#71

Post by LinuxBender » Tue, Sep 10, 2019, 9:14 PM UTC

AstralStorm wrote: post #54

mrfusion wrote: post #40

Earlier quoted context omitted.

In my mind that’s what makes this kind of a garbage study.

Alongside focus on just osteoporosis, lack of control for calcium levels (other than blind supplementing with low dietary intake), phosphate levels. Some people may be responding poorly to the supplement, especially at high doses and low calcium. Direct blood test for status would help.

CAC tests are a good indication if D3+K2+mag is mobilizing calcium. That is of course if your current CAC score is above 0 which it should not be.

Re: Effect of High-Dose Vitamin D on Volumetric Bone Density and Bone Strength

#72

Post by nradov » Wed, Sep 11, 2019, 3:13 AM UTC

nikolay wrote: post #70

nradov wrote: post #56

Earlier quoted context omitted.

You would probably benefit more from being out in the sun than from taking vitamin D supplements.

Yeah, and possibly die of malignant melanoma. At the same time, no sun exposure is also a risk of melanoma - not sure if due to vitamin D or more possibly - due to the hormetic effect of mild skin DNA damage.

A little daily sun exposure won't significantly increase your risk of melanoma (unless you have a rare genetic disorder).

Re: Effect of High-Dose Vitamin D on Volumetric Bone Density and Bone Strength

#73

Post by nikolay » Wed, Sep 11, 2019, 3:57 AM UTC

nradov wrote: post #72

nikolay wrote: post #70

Earlier quoted context omitted.

Yeah, and possibly die of malignant melanoma. At the same time, no sun exposure is also a risk of melanoma - not sure if due to vitamin D or more possibly - due to the hormetic effect of mild skin DNA damage.

A little daily sun exposure won't significantly increase your risk of melanoma (unless you have a rare genetic disorder).

True, but you get enough vitamin D - especially not during the winter.

Re: Effect of High-Dose Vitamin D on Volumetric Bone Density and Bone Strength

#74

Post by matthewdgreen » Wed, Sep 11, 2019, 1:13 PM UTC

airstrike wrote: post #67

matthewdgreen wrote: post #66

Earlier quoted context omitted.

2/3 of Americans get the RDA of Vitamin D. Picking a specific outlier case for your control group wouldn't make a lot of sense for a scientific study (not to mention, as others have pointed out in this thread, would be difficult or unethical.) If you are a vegan living in a low-sunlight location, look into supplementation.

So you're saying 1/3 of Americans don't get the RDA of Vitamin D, yet calling 33% of cases "an outlier" I'm not vegan and I actually take Vitamin D3 supplements, but wanted to point out the flaw in assuming that everyone is in the same bucket as me.

I'm saying that probably a very tiny percentage of Americans get 0 IU. Which makes 0 IU a very poor choice of a baseline. Since you need some concrete amount to use for your control group, what would you propose using?

Re: Effect of High-Dose Vitamin D on Volumetric Bone Density and Bone Strength

#75

Post by pcvarmint » Thu, Sep 12, 2019, 2:33 AM UTC

I have osteomalacia, and I have suffered 4 bone fractures in the last 4 years, two spontaneously: one during my sleep, and one while twisting in my car to pick up something from the passenger seat.

I take Vitamin D, Calcium, and alendronate (Fosamax), and when the sun is out, I go out for a while without sunscreen.

My last DXA (2.8 years ago) had a Z-score of -2. I'm only in my 40's, so I don't have a T-score.

I don't really care about the validity of this study. I just know I have to take Vitamin D and Calcium supplements regularly, and Magnesium less often, but regularly.