If 9 people took a substance and died that would be a compelling enough sample size for me not to take thing. Likewise, 9 people reporting a positive result seems meaningful enough to encourage further study (provided effect size is large enough)..
With the placebo being so strong, sample size of 9 is too small for any conclusion.
The article mentions the effects persisted even a year after treatment. That's far beyond the placebo effect for anything I'm aware of.
When you do an exploratory experiment you want to have your group to be as homogeneous as possible. That's why there are lines of lab mice which are nearly clones of each other.
Never ascribe to racism that which can be adequately explained by your own ignorance.
Long term or repeated fasting should actually decrease your body's metabolism rate; which is a good thing if you want to age slower. (I.e. think about species who have slow metabolisms, turtles, for one, who live very long lives). I do alternate day fasting (48 hour fasts, every other day) and realized I now need far fewer calories to get by than I used to. Obviously anecdotal but I feel great!
How did you work up to fasting?
It’s just another challenge in life like all the other ones. Once you’ve started dipping your toes in you slowly realize the state of homeostasis starts to feel a bit perverse. Obviously it feels good to be fed, but, like in other areas of life, if we never chose to find what our next frontier is and push our limits we won’t grow personally. Some people are fine with that obviously, but I’ve always been one to push my limits. Concretely though, I started with 16/8 then narrowed it down to like a 3 hour eating window then just decided I could go all out alternate day fasting. Now I do something like a 45 hour fast with 3 hour eating window, perpetually; and a 72 hour fast once a month.
Sounds like you could successfully fast very easily by eating the same amount of food in shorter period of the day, like 16h fasting and eating in the remaining 8h of the day. Without changing the amount of daily calories you wouldn't experience weight loss. Obviously saying 'could' is not the same as saying 'should' and it's not very safe to do drastic changes to your diet without consulting a MD.
Eating the same amount of food in a much shorter period is also a great way to train your stomach to accept (and unfortunately, expect) more food before feeling full.
Is that a well-documented truth, or just something you think seems right? The opposite has been true for me for the last few years of sort of informally fasting: I hit uncomfortable satiety faster when fasting.
Biology is not that simple. There's not going to be a single magic compound. Slowing the aging process is massively complex and will probably require a cocktail of treatments
Why do you say that? Biology is usually very simple. Eat food, live. Don't eat food, die. Drink water, live. Don't drink water, die. Just because you don't happen to know the answer doesn't mean the answer is complicated.
Writing an optimizing compiler is child's play. Just type some letters and numbers, hit save, and you are done.
36 year old male here. Using metformin to artificially lower my blood sugar level to help keep weight off and for life extension purposes (asked my doctor for a prescription at my annual physical, said "sure, go for it"). Highly recommend it.
How much are you taking? Do you use it to stay in ketosis, along with Intermittent Fasting, or something else? Is there any good literature for using this outside of it's intended use for diabetes? Thanks!
500mg once daily, one meal a day intermittent fasting (dinner). Only coffee, Coke Zero, and water outside of dinner.
It just dawned on me that getting old and dying is most likely an evolutionary chicken and egg problem. If you didn't get old and die, evolution of your species would grind to a halt. Getting old and dying is required for evolution to transpire. I can't see any reason why it must be an absolute truth.
Dying isn't required for evolution.
It's just that after you reproduce and get your offspring on their own feet, continuing to live is optional (for evolution), so no optimizations evolved to continue life far beyond that.
Evolution isn't trying to kill you, it just doesn't care about helping you beyond reproductive age.
Studies cost a ton of money. If you can get an interesting signal in a small study, that can be a good reason to invest more money. If you get s strong signal for a surprising result, it's worth talking about and can get into serious journals.
44 yo male. DHEA is amazing. In times of stress, it restores my libido and ends my depressive cycle. I don't take it every day, but I definitely keep it close by.
"Studies have shown quality control of this supplement to often be low." [1] -- which one are you using? [1] https://www.mayoclinic.org/drugs-supplements-dhea/art-203641...
Natrol. No particular reason, just got it off Amazon.
44 yo male. DHEA is amazing. In times of stress, it restores my libido and ends my depressive cycle. I don't take it every day, but I definitely keep it close by.
36 year old male here. Using metformin to artificially lower my blood sugar level to help keep weight off and for life extension purposes (asked my doctor for a prescription at my annual physical, said "sure, go for it"). Highly recommend it.
Metformin is great. A doc even recommended it to my friend while he was fighting a glioblastoma(brain cancer).
I'd love to take it but I tried berberine, which is supposedly similar in effect, and got major low blood sugar.
The only issues with Metformin are occasional digestive issues(diarrhea) and the slight chance of lactic acidosis.