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In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

nature.com

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Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#91

Post by joe_the_user »

arcticbull wrote: post #57
Wowfunhappy wrote: post #19

Earlier quoted context omitted.

> So, this (lousy, but interesting) study is basically "fasting by using drugs." That sounds to me like a big deal, given that most people find fasting difficult (and unpleasant).

Fasting is easy and fun, you just have to work up to it. You can just go from zero to not eating for a week. Building up your tolerance to it takes a bit, like anything else, but when you do it improves mental acuity, gets you a general sense of well-being and energy too.

My body weight puts me barely above underweight when I eat as much as I feel like. I don't think regular week long fasts could be very healthy for me.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#92

Post by ilkan »

nikkwong wrote: post #80
RandomTisk wrote: post #76

Earlier quoted context omitted.

Have you experienced additional mental acuity/focus first hand? Fasting for 24-36 hours for me isn't bad. But days 2 to 3 when I do a 3 day fast I find it extremely difficult to concentrate/focus on anything difficult. By day 3 my energy is usually shot as well and I just don't want to do anything but watch tv. If anyone has advice beyond sugar I'd love to hear it.

Are you supplementing with electrolytes? You need magnesium citrate + salt + potassium. Without that I can't achieve fasts longer than 48 hours.

Water-only fasting was popular in sanatoriums and weight loss spas in the late 1800's/early 1900's... practice was stopped after lack of electrolytes caused several patient deaths from heart arrhythmias.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#93

Post by zarkov99 »

coldtea wrote: post #54
mindslight wrote: post #36

Earlier quoted context omitted.

Plus ça change. I wouldn't have thought racism would become popular again, but here we are.

Or, well, victorian tiptoeing around language becoming popular again, to avoid saying the obvious: most rich people in our society are white...

Yes, and that is what one would expect when most people are white in the first place.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#95

Post by vilaca »

joe_the_user wrote: post #91
arcticbull wrote: post #57

Earlier quoted context omitted.

Fasting is easy and fun, you just have to work up to it. You can just go from zero to not eating for a week. Building up your tolerance to it takes a bit, like anything else, but when you do it improves mental acuity, gets you a general sense of well-being and energy too.

My body weight puts me barely above underweight when I eat as much as I feel like. I don't think regular week long fasts could be very healthy for me.

Sounds like you could successfully fast very easily by eating the same amount of food in shorter period of the day, like 16h fasting and eating in the remaining 8h of the day. Without changing the amount of daily calories you wouldn't experience weight loss.

Obviously saying 'could' is not the same as saying 'should' and it's not very safe to do drastic changes to your diet without consulting a MD.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#96

Post by jvagner »

stickfigure wrote: post #62
arcticbull wrote: post #57

Earlier quoted context omitted.

Fasting is easy and fun, you just have to work up to it. You can just go from zero to not eating for a week. Building up your tolerance to it takes a bit, like anything else, but when you do it improves mental acuity, gets you a general sense of well-being and energy too.

Your idea of 'fun' and my idea of 'fun' are wildly different.

The idea of fasting and the reality of fasting are different. The idea is more painful than a committed effort. Once you accept and embrace the fast, it’s freeing. Like running every day.... once you know you’re going to do it, the resistance withers.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#97

Post by Iv »

scottlocklin wrote: post #6

1) DHEA is not a diabetes med. In fact it's a steroid (not really an anabolic one, though it is a precursor to anabolics) and illegal in the EU. It is a substance which is lowered in older people, so older people supplement with it. 2) Metformin is a diabetes med, and it's used by antiaging enthusiasts independently and along with growth hormone 3) Fasting creates larger growth hormone spikes, and improves sugar clea…

> antiaging enthusiasts

Never heard of that crowd. What is it that they do? Try experimental treatments on themselves?

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#98

Post by nanomonkey »

toomuchtodo wrote: post #63
01100011 wrote: post #59

Earlier quoted context omitted.

44 yo male. DHEA is amazing. In times of stress, it restores my libido and ends my depressive cycle. I don't take it every day, but I definitely keep it close by.

36 year old male here. Using metformin to artificially lower my blood sugar level to help keep weight off and for life extension purposes (asked my doctor for a prescription at my annual physical, said "sure, go for it"). Highly recommend it.

How much are you taking? Do you use it to stay in ketosis, along with Intermittent Fasting, or something else? Is there any good literature for using this outside of it's intended use for diabetes? Thanks!

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#99

Post by webmaven »

vilaca wrote: post #95
joe_the_user wrote: post #91

Earlier quoted context omitted.

My body weight puts me barely above underweight when I eat as much as I feel like. I don't think regular week long fasts could be very healthy for me.

Sounds like you could successfully fast very easily by eating the same amount of food in shorter period of the day, like 16h fasting and eating in the remaining 8h of the day. Without changing the amount of daily calories you wouldn't experience weight loss. Obviously saying 'could' is not the same as saying 'should' and it's not very safe to do drastic changes to your diet without consulting a MD.

Eating the same amount of food in a much shorter period is also a great way to train your stomach to accept (and unfortunately, expect) more food before feeling full.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#100

Post by James_Henry »

scottlocklin wrote: post #6

1) DHEA is not a diabetes med. In fact it's a steroid (not really an anabolic one, though it is a precursor to anabolics) and illegal in the EU. It is a substance which is lowered in older people, so older people supplement with it. 2) Metformin is a diabetes med, and it's used by antiaging enthusiasts independently and along with growth hormone 3) Fasting creates larger growth hormone spikes, and improves sugar clea…

Fasting does increase growth hormone amount and spike frequency, but it also makes you growth hormone resistant https://www.sciencedirect.com/science/article/pii/S155041310...

Why is it lousy to do formal research on "stacks" people have been using for years?

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