In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’
1–10 of 198 posts
Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’
#29 people, no control group.
Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’
#39 people, no control group.
Biomimicry. Start with what we know works: the 9 lives of a cat.
Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’
#49 people, no control group.
The results were a surprise even to the trial organizers — but researchers caution that the findings are preliminary because the trial was small and did not include a control arm.
Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’
#5Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’
#61) DHEA is not a diabetes med. In fact it's a steroid (not really an anabolic one, though it is a precursor to anabolics) and illegal in the EU. It is a substance which is lowered in older people, so older people supplement with it.
2) Metformin is a diabetes med, and it's used by antiaging enthusiasts independently and along with growth hormone
3) Fasting creates larger growth hormone spikes, and improves sugar clearance. Dunno what it does to DHEA; eat lots of eggs for that one.
So, this (lousy, but interesting) study is basically "fasting by using drugs." Meat heads and antiaging people have done stacks like this for years. Unclear whether or not it actually helps with longevity, but it probably improves quality of life. So does fasting, and it don't cost as much.
Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’
#79 people, no control group.
"Enough for Nature! Next time, let's see if we can get away with 8!"
Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’
#89 people, no control group.
9 men, no less.
Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’
#9I'd wager that it's the metformin. Metformin inhibits pathways associated with mTOR (the growth signaling protein). When you inhibit this pathway, it tells the body to start the process of autophagy. It's the same process that occurs during fasting, and it's the same reason that the mTOR inhibitor Rapamycin has been shown to extend lifespan in mice and dogs. This is also why fasting has been shown to increase lifespan. It seems like if you don't constantly tax your body with food (growth signaling), then you can allow the body to repair itself. If you don't give it a break through fasting, then your growth hormones will be continually signaling to activate mTOR within your cells and thus never start the process of autophagy (cell death, and regrowth).
Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’
#10The sample size is so small, that the results are nearly meaningless.