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Acute Effects of Electronic Cigarette Aerosol Inhalation on Vascular Function

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Re: Acute Effects of Electronic Cigarette Aerosol Inhalation on Vascular Function

#181

Post by Medicalidiot »

rapjr9 wrote: post #175
mrfusion wrote: post #139

Earlier quoted context omitted.

Is there any research on what other chemicals might be addictive?

There is evidence that some additives enhance addiction and that others suppress the side effects from smoking (coughing, burnt throat, feeling ill, etc.) so that when someone quits smoking they have essentially stopped treating themselves for all these side effects, which then appear and make the person feel miserable. Smoking instantly relieves symptoms again (for a while): https://www.ncbi.nlm.nih.gov/pmc/articles…

>So it appears that although nicotine is mildly addictive

It's not mildly addictive

https://en.wikipedia.org/wiki/Substance_dependence#Dependenc...

Re: Acute Effects of Electronic Cigarette Aerosol Inhalation on Vascular Function

#182

Post by Medicalidiot »

JamesBarney wrote: post #61
Medicalidiot wrote: post #39

The number one controllable risk factor for stroke and heart attack is smoking. By far. Not diet, not exercise, smoking. A significant part of that is because nicotine will constrict blood vessels leading to hypertension[1], this leads to destruction of the surface of an artery, leading to atherosclerosis formation. One day the atherosclerotic plaque ruptures and then you see me. We once thought that atherosclerosis…

Smoking is one of the leading risk factors for cardiovascular disease: agreed It starts earlier than a lot of people thought: agreed The primary contributor to smoking's detrimental effects on the cardiovascular system is nicotine: disagree Mind linking to something that shows this? That doesn't agree with the results from the UK study on effects of nicotine versus smoking which puts nicotine's effects at about 5% of…

>The primary contributor to smoking's detrimental effects on the cardiovascular system is nicotine: disagree

Where did I say that?

I don't what UK study you're referring to, the ones I used are published in American and Middle Eastern journals.

Re: Acute Effects of Electronic Cigarette Aerosol Inhalation on Vascular Function

#183

Post by chrismarlow9 »

ozzmotik wrote: post #134
ozzmotik wrote: post #69

sorry if this comment is against the spirit of the community (i don't think it is, but I have been blocked from posting in the past oblivious to the fact that I wasn't contributing anything meaningful), but that being said... am I the only one who isn't surprised that someone managed to find that if you introduce something into the body that isn't generally there, that there is obviously going to be an acute response…

sometimes i really wish that people would actually tell me why they downvote what I have to say, rather than just silently doing so and condemning me to the bottom of the comments. i can't really really do the revision part of performance, feedback, revision without any actual feedback of substance to inform me as to what it is that I did wrong in the first place.

you're using too many words to say something simple. that and the comment comes off a little as "well i can see the point of X, but I can also see the point of Y"... which isn't really saying anything. Just my 2 cents.

Re: Acute Effects of Electronic Cigarette Aerosol Inhalation on Vascular Function

#184

Post by grawprog »

lowdose wrote: post #173
grawprog wrote: post #171

Earlier quoted context omitted.

I don't smoke the juul vapes, they're not the only company that makes nicotine salt juice. Nicotine salts are made by adding an acid to freebase nicotine, which is still made originally via extracting nicotine from tobacco and processing it with ammonia. If you smoke nicotine, you're inevitably supporting large tobacco producers, there's not really much way around that. Then there's the matter of, freebasing an alkal…

I have seen the effects of crack also from nearby but the effects usually lasts from 5–10 minutes. Snorting quality cocaine last an hour. I'm not a chemist so you good be spot on in the information you provide. I'm just sharing my positive experience with freebase and hope more people can quit smoking. Taste is such a personal thing, I don't like sweets either and this flavor was delivered by accident because the sto…

https://en.m.wikipedia.org/wiki/Free_base

>Freebasing is a more efficient method of self-administering alkaloids via the smoking route. For example, cocaine hydrochloride decomposes at the high temperatures necessary for smoking. Free base cocaine, in which the cocaine alkaloid is "freed" from the hydrochloride salt, has a melting point of 98 ℃ and is volatile at temperatures above 90 ℃, therefore providing an active drug for smoking. After inhalation the alkaloid is absorbed into the blood stream and rapidly transported throughout the body. However, since blood is buffered with carbonate at physiological pH (near 7.4), free-base amines will be rapidly converted back into their acid form. In fact, 94.19% of cocaine will exist as the acid form under equilibrium at pH=7.4, calculated using the Henderson-Hasselbalch equation assuming a pKa of 8.61[1].

Re: Acute Effects of Electronic Cigarette Aerosol Inhalation on Vascular Function

#185

Post by glloydell »

rkimmel wrote: post #178

I’m tired of vaping companies claiming it’s safe. Glad the truth is finally getting out. The only safe alternative to cigarettes is to not smoke at all.

Can you point me towards any advertising campaigns or promotional material claiming that vaping is "Safe"? Not safer, but safe.

Re: Acute Effects of Electronic Cigarette Aerosol Inhalation on Vascular Function

#186

Post by esotericn »

rapjr9 wrote: post #175
mrfusion wrote: post #139

Earlier quoted context omitted.

Is there any research on what other chemicals might be addictive?

There is evidence that some additives enhance addiction and that others suppress the side effects from smoking (coughing, burnt throat, feeling ill, etc.) so that when someone quits smoking they have essentially stopped treating themselves for all these side effects, which then appear and make the person feel miserable. Smoking instantly relieves symptoms again (for a while): https://www.ncbi.nlm.nih.gov/pmc/articles…

There's a great PDF (British action group I believe? I read it ages ago) which goes in to depth on the various mechanisms the tobacco companies employed in order to increase the addiction potential of cigarettes.

A modern cigarette is not just a roll of tobacco. It's pretty much been 'bred', A-B tested, into being a drug delivery system.

Re: Acute Effects of Electronic Cigarette Aerosol Inhalation on Vascular Function

#187

Post by enraged_camel »

caymanjim wrote: post #162
abstractbarista wrote: post #93

Earlier quoted context omitted.

This is definitely a point which needs more exploring. Seems to me most damage from smoking is all the crap in smoking. The chemical nicotine - by itself - transiently raises BP, feels nice, and that's about it. It's also only a part of the addictiveness of smoking. Probably a small part, as everyone I know who has consumed nicotine in any form has no trouble without it if they vape, but often shows discomfort/restle…

I've been a long-time smoker, and at least for me, nicotine alone does absolutely nothing to alleviate cravings. Gum, patches, lozenges, vaping, etc. do zero to alleviate my craving for a cigarette. I'm not discounting that nicotine is addictive (I'm in no position to say), but there's got to be something else in tobacco that is part of the addiction.

Addiction has two components: chemical(i.e. nicotine) and psychological (i.e. the habit of the ritual).

My mom recently switched to e-cigarettes, and she said that she still occasionally gets the urge to smoke a real cigarette. But she said the urge is a lot weaker than when she used to go prolonged periods without smoking cigarettes, such as after a long plane ride.

Re: Acute Effects of Electronic Cigarette Aerosol Inhalation on Vascular Function

#188

Post by brokensegue »

seanmcdirmid wrote: post #113
DanBC wrote: post #95

Earlier quoted context omitted.

Not if non-smokers are being recruited into vaping or smoking.

Hasn’t that always been the case though? Peer pressure is going to be directed somewhere, maybe cigarettes, maybe marijuana, maybe heroin, ... are kids really expected to be better these days than when we were kids?

to non-drugs?

Re: Acute Effects of Electronic Cigarette Aerosol Inhalation on Vascular Function

#189

Post by dumbfoundded »

noobiemcfoob wrote: post #138
dumbfoundded wrote: post #27

If you believe E-Cigs are harmless, there's an easy experiment you can do for yourself. Go on a run, time yourself. The next day, vape for 30 min and then go on the same run. This is what got me to personally switch away from E-Cigs. Vaping would add an additional 30-sec to 1-min per mile on my runs. I try to only use patches or gum now. Still not great but it's a lot better if you're trying to stay in shape. That be…

Are most people in the type of shape that 30 seconds per mile variance day to day is surprising? I don't time myself, but I'd be surprised if any two of my sprints aren't this different normally.

I run 5 miles 3 times a week. Usually on the same loop. I use the stopwatch app on my phone.

Re: Acute Effects of Electronic Cigarette Aerosol Inhalation on Vascular Function

#190

Post by topmonk »

caymanjim wrote: post #162
abstractbarista wrote: post #93

Earlier quoted context omitted.

This is definitely a point which needs more exploring. Seems to me most damage from smoking is all the crap in smoking. The chemical nicotine - by itself - transiently raises BP, feels nice, and that's about it. It's also only a part of the addictiveness of smoking. Probably a small part, as everyone I know who has consumed nicotine in any form has no trouble without it if they vape, but often shows discomfort/restle…

I've been a long-time smoker, and at least for me, nicotine alone does absolutely nothing to alleviate cravings. Gum, patches, lozenges, vaping, etc. do zero to alleviate my craving for a cigarette. I'm not discounting that nicotine is addictive (I'm in no position to say), but there's got to be something else in tobacco that is part of the addiction.

Have you ever tried Swedish Snus? It's supposedly healthier than smoking, and no need to spit like chewing tobacco.

If you try it. make sure you get fresh stuff before you pass judgment, because it ferments inside the package if left out for too long.

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