The problem is incentives, not sure why this guy wrote a whole book without realising this, but it is an easy mistake to make if you are thinking about the problem from your writing desk. People will minimise effort and cost, given a choice, and maximise profit subject to constraints. This behaviour exists even in highly trained health professionals already making many hundreds of thousands of dollars a year. Example - why do primary care doctors prescribe minimally effective drugs for depression? Is it because they can't understand a meta-analysis, can't remember all the patients the drugs didn't work for in their own practice, or because they are lazy or stupid? It is because a patient has come in looking for help and is sitting there in tears, and there is only 10 minutes to see them, and the history from the other doctor this person has been seeing for the last 5 years isn't available. And although everyone would be better off if the doctor spent an hour finding out in detail what is going on, carefully talking over the options, the side effects of various treatments and reaching a consensus management plan which starts with non-pharmacological therapies, and activates a government program which allows the patient to take extra time off work to attend therapy sessions with childcare facilities included. But it is easier for everyone to prescribe Prozac. This is the reality. Perverse incentives explain many of the problems in Medicine and healthcare systems. Nobody gets paid for delivering good care, nobody saves money by accepting good care. As shocking as it may be, delivering good care or exceptional care is a choice a health care team makes despite everything else. Similarly, accepting proven health care interventions is a choice a patient makes. Usually everything doesn't line up, and that is modern medicine.
The cited example of Gleevec also makes no sense to me. It revolutionised the treatment of 2 conditions which were almost completely untreatable beforehand (Chronic Myeloid Leukaemia and Gastrointestinal Stromal Tumour). The alternatives to taking Gleevec for these patients were A) Toxic minimally effective chemotherapy followed by death or B) Just death. All of this context is extremely important in discussing the side-effects which can be severe. This is what the patient and the doctor work out together. Some throwaway line about how toxic it is just makes no sense in isolation.