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Cannabidiol in Anxiety and Sleep: A Large Case Series

ncbi.nlm.nih.gov

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Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#121

Post by jokowueu »

raducu wrote: post #101
jokowueu wrote: post #94

Earlier quoted context omitted.

I'm am glad you are helping your daughter thought this . This disease is such a cruel thing to have . I would like to offer some extra info . Since you are looking for OTC . Both NAC and SACROSINE have a lot of great research when it comes to schezophrenia. It seems to work for some but not others.also new research into TMG (betaine glycine) is also interesting There is also a new drug on the horizon that doesn't wor…

I have a mutation which results in impaired BDNF and I do suffer from anxiety; so far buspirone seems to work, but I was considering SEMAX/SELANK for the BDNF increase, do you know anything about that?

Semax can make your hair fall out slightly selank doesn't . Ive heard good stories about both . Try them both out but start with semax . Do it long term .

Fasting can increase bdnf by 3.5 times . Research intermittent fasting and also long term fasting (48 hours) .

There is just so much that can increase bdnf but as a rule of thumb when it comes to herbs . Studies mostly are short term and just not as good .

I recommend coming over to the nootropics subreddit and research/ask there

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#122

Post by newsgremlin »

spectramax wrote: post #6

Stupid question but I’ve always wondered this - I hear Cannabis is used for anxiety relief but doesn’t smoking marijuana induce anxiety? Everyone I know who has smoked weed agrees with my experience - they’ve encountered some level of anxiety and paranoia. So, how exactly does weed help in reducing anxiety? Edit: Follow up question -> Is weed used to treat anxiety during the high or when you are normal (and have gene…

From my experience and own research it's highly dependent on the ratio of THC to CBD (there are over one hundred cannabanoids in the plant which have the desired benefits, but for simplicity sake just these two are used in general discussion). I found when I have recently experienced, or have underlying feelings of general anxiety, high THC strains make the anxiety worse, ruminating thoughts become unbearable. The more you take the worse this feeling gets. (Edibles can be a horrible experience in this state)

Essentially it depends on your predisposition to anxiety, the dosage you take, and the ratio of THC to CBD.

Balanced ratios that would make this much less likely and induce a more relaxed or energetic state depending on the more dominant chemical. Unfortunately the legality of it makes it impossible to verify the ratios of cannabis substances

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#123

Post by superkuh »

The dosages of CBD used in this study are far, far, too low to have any effect. Just like most CBD dosing in commercial situations. Usually scientific investigation use the actual useful dosages of 300-600 mg in humans. I guess these guys didn't do the required background review beforehand.

CBD is not active at the CB1 or CB2 receptors. It has very low affinity for them. It has moderate affinity for the serotonin-1a autoreceptor (that the anti-anxiety medication buspirone also targets). But only at very high dosages (ie, 300mg+).

So... this study has only really tested the placebo effect.

edit: I finished reading the journal article and it turns out they didn't use clinically relevant doses because it'd cost too much. So they decided to just go the placebo route.

>The doses used in this study (25 mg/d to 175 mg/d) were much lower than those reported in some of the clinical literature (300 mg/d to 600 mg/d)12–14,17 for 2 reasons. The first is that in our experience lower doses appear to elicit an adequate clinical response. Second, the current retail cost of CBD would make the use of 600 mg/d cost prohibitive.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#124

Post by driverdan »

jaequery wrote: post #68
nikkwong wrote: post #57

Earlier quoted context omitted.

Where have you read that CBD increases the amount of deep sleep? I have looked into this quite extensively, and never found any information that suggested that.

Joe Rogan https://youtu.be/Pjeb9kOSJ2M I think it was this but it could’ve also been some online article.

Joe Rogan is not a primary source.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#125

Post by OldSchoolJohnny »

instakill wrote: post #106
clarityPhone wrote: post #84

Earlier quoted context omitted.

I get anxiety when I smoke and am way too young to attribute it to any sort of “reeder madness” - so it’s definitely a thing. I don’t smoke super often, and don’t always get anxiety when I do, but it definitely gave me terrible anxiety when I was younger. If anyone else gets anxiety when they smoke, I recommend smoking sativa instead of indica (nicknamed “in da couch” because of its anxiety effects). I was given the…

1) you got the 2 mixed up, it's indica that's the in-da-couch. Sativa is the brain-high. 2) there's little evidence to prove that sativa/indica strains affect your high. The curing, drying, growing of each individual plant alters the THC-CBD-CBG ratios way more than strain or species.

Point number 2 is utterly untrue as any experienced cannabis enthusiast could tell you. Even if people don't know the strain or what the effects are it's pretty reliable that it will either energize them or send them to sleep.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#126

Post by OldSchoolJohnny »

_carl_jung wrote: post #105
grahamburger wrote: post #85

Earlier quoted context omitted.

Interesting - I had assumed the opposite! I picked up a few different blends a while back hoping to address some (relatively mild) social anxiety and it worked well at first but later started giving me horrible anxiety (oddly only later that night - I'd take a small dose in the morning and be fine all day, then freak out from 1am to 4am.) Tried a bunch of different blends of thc:cbd with little luck, but I was sticki…

I think they have this the wrong way round. Indica is known for its relaxation effects. Couch lock isn't due to anxiety but relaxed passivity, and sativa strains tend to promote overthinking and paranoia in those (inc. myself) prone to it.

No. It depends on the person entirely and if you start digging you will find about equal distribution of people who are calmed by a sativa and people who are calmed by an indica. I personally suspect that people who feel calm from a sativa are a little ADHD and it seems to make them think better and more calmly and indicas make them much more anxious because it exacerbates and existing condition.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#127

Post by leshow »

clarityPhone wrote: post #84
oblib wrote: post #62

I have some current experience with my adult daughter suffering with severe anxiety. I started looking for over the counter treatments and found studies that used magnesium glycinate successfully as a treatment and it has worked wonders for her. She takes a 300 mg tab and in 20 minutes she's completely calmed down. It only lasts for about four hours but the effect is amazing. The downside is it can cause diarrhea whe…

I get anxiety when I smoke and am way too young to attribute it to any sort of “reeder madness” - so it’s definitely a thing. I don’t smoke super often, and don’t always get anxiety when I do, but it definitely gave me terrible anxiety when I was younger. If anyone else gets anxiety when they smoke, I recommend smoking sativa instead of indica (nicknamed “in da couch” because of its anxiety effects). I was given the…

I hear this repeated a lot in different variations, some people say the exact opposite, but it's untrue.

There's no real definition of what a '100% sativa' or '100% indica' even is. All we have to go by are characteristic leaf patterns between indica/sativa. In short, the whole 'indica body buzz' thing is unfounded. In fact, I remember hearing the EXACT opposite of what you heard a few years ago. I was told that sativa caused anxiety and indica was more calming.

The reality is that the only differences between strains are in combinations of THC to CBD. Plants with higher CBD and lower THC will be more 'calming' and plants with higher THC and lower CBD will get you more high, which can produce more anxiety in people sensitive to THC.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#128

Post by leshow »

OldSchoolJohnny wrote: post #125
instakill wrote: post #106

Earlier quoted context omitted.

1) you got the 2 mixed up, it's indica that's the in-da-couch. Sativa is the brain-high. 2) there's little evidence to prove that sativa/indica strains affect your high. The curing, drying, growing of each individual plant alters the THC-CBD-CBG ratios way more than strain or species.

Point number 2 is utterly untrue as any experienced cannabis enthusiast could tell you. Even if people don't know the strain or what the effects are it's pretty reliable that it will either energize them or send them to sleep.

It's not untrue, there is no definition genetically of what a pure sativa/indica strain even is, see my other comment here.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#129

Post by leshow »

sharadov wrote: post #77
hn_throwaway_99 wrote: post #23

Earlier quoted context omitted.

In my experience, if I smoke a very small amount of weed (like literally one hit) it can relax me and make me less anxious. It slows things down, and can just generally numb some of my underlying anxieties. However, it doesn't take much for me to cross that threshold where it can make me extremely paranoid. Usually this is what I call the "will I be stuck this way forever" threshold, where I get stoned to the point w…

Depends on whether you are smoking a sativa or indica, and what kind of activity you are involved in? Are you smoking alone or in a group setting. If you are smoking alone and have an anxious personality, I would rather smoke a Sativa strain with a higher CBD to THC ratio. Indicas sometimes take me to an anxious place, but it depends on my mental state before taking the drug. So much of it is setting ( great music, g…

> Depends on whether you are smoking a sativa or indica

People really need to stop repeating this. There are pure cbd sativas just as there are pure cbd indicas. There is no definition for what a sativa/indica is besides what the leaves look like. There's no bearing on subjective high and strains. What people are experiencing is differing THC/CBD ratios.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#130

Post by thedaemon »

leshow wrote: post #127
clarityPhone wrote: post #84

Earlier quoted context omitted.

I get anxiety when I smoke and am way too young to attribute it to any sort of “reeder madness” - so it’s definitely a thing. I don’t smoke super often, and don’t always get anxiety when I do, but it definitely gave me terrible anxiety when I was younger. If anyone else gets anxiety when they smoke, I recommend smoking sativa instead of indica (nicknamed “in da couch” because of its anxiety effects). I was given the…

I hear this repeated a lot in different variations, some people say the exact opposite, but it's untrue. There's no real definition of what a '100% sativa' or '100% indica' even is. All we have to go by are characteristic leaf patterns between indica/sativa. In short, the whole 'indica body buzz' thing is unfounded. In fact, I remember hearing the EXACT opposite of what you heard a few years ago. I was told that sati…

In general the rule of thumb is sativa is a head high and indica is a body high.
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