WINE needs 32 bit support. The bulk of windows programs that people still care about are from the 32 bit era, and as they point out many 64 bit apps use 32 bit installers. Maybe it's time for x86 box like DOSbox.
> Maybe it's time for x86 box like DOSbox ...or Virtualbox.
It's also worth considering the context, WINE (WINE Is Not an Emulator) provides an abstraction layer that doesn't require the overhead of an emulation layer.
DOSbox is similar. (EDIT: apparently it's not, and is actually an emulator. TIL.)