Live data from Hacker News

Inflammation might be the root of preventable disease

harvardmagazine.com

131–140 of 240 posts

Re: Inflammation might be the root of preventable disease

#131

I found this area interesting: > “A fat cell is almost like a primitive immune cell,” says Hotamisligil. “It can request the assistance of immune cells when in trouble, but if the stress continues, and the immune cells remain, they start changing their character and behavior from helpful to harmful.” ... > When overloaded with stored lipid, fat cells begin to lose their functional and structural integrity and may sta…

Book recommendation - "Toxic Fat" by Barry Sears (disclosure - the father of a friend of mine). Its thesis is in line with much of the research in this article.

Re: Inflammation might be the root of preventable disease

#132

What causes inflammation? There are ingredients in most commonly sold processed foods that are level 1, 2, and 3 on the hazmat scale.

Name them.

Here's one, grandfathered in 1958...

https://en.wikipedia.org/wiki/Sorbic_acid

For the rest, just pull on the wiki-thread.

Re: Inflammation might be the root of preventable disease

#133

My prediction: 1) reducing chronic inflammation by, for example, exercise or eating better food, is proven to have good health effects 2) pharmaceutical companies try to make that into a pill 3) dang, the benefits of the pill are not nearly as big as if you exercise and eat better food, and not nearly as big as our early trials of the drug indicated they would be 4) we must need a different kind of pill

Resveratrol was such a pill/fad, with some companies going belly up eventually.

Re: Inflammation might be the root of preventable disease

#134
post #100
post #85

Earlier quoted context omitted.

I'd predict the pharmaceutical pill will be damaging! Our body is very smart and heals most things by itself, given the right nutrition.

This sounds like some anti-vaxx reasoning.

Only partially, a lot of ailments nowadays are 'wealth diseases' caused by lifestyle and obesity.

Re: Inflammation might be the root of preventable disease

#135
post #124

My prediction: 1) reducing chronic inflammation by, for example, exercise or eating better food, is proven to have good health effects 2) pharmaceutical companies try to make that into a pill 3) dang, the benefits of the pill are not nearly as big as if you exercise and eat better food, and not nearly as big as our early trials of the drug indicated they would be 4) we must need a different kind of pill

Bottom line: pharma sells pills to make money; they don't make money off of healthy people who don't take their pills. So long as we link the health industry to making profit, we are prioritizing profits over health.

Profits are what drives innovation in pharmaceuticals.

Re: Inflammation might be the root of preventable disease

#136
post #5

Earlier quoted context omitted.

> Critics might suggest that inflammation is just a symptom in these diseases, rather than a cause. But Hotamisligil says, unequivocally, “Chronic inflammation is uniformly damaging and is absolutely causal to the process, because if you interfere with it, you can reverse the pathology.” And this ability to control such diseases simply by reversing inflammation is a biological response, dating far back to the time of…

Getting off-topic, but how do biologists define the "highness" of an organism?

I slipped and wrote "higher eukaryotes" in relation to yeast and this is my post-doc's comments:

"that broke my heart :( other eukaryotes? multicellular eukaryotes? animals? Whatever you like, but please, no "higher", the poor yeast have been evolving for a long time and are much better than us at fermenting beers..."

This is a great paper that touches on animal complexity, see "Developmental Depth" and "Structural depth" https://www.researchgate.net/publication/228365097_Possible_...

Re: Inflammation might be the root of preventable disease

#137
post #100
post #85

Earlier quoted context omitted.

I'd predict the pharmaceutical pill will be damaging! Our body is very smart and heals most things by itself, given the right nutrition.

This sounds like some anti-vaxx reasoning.

Sounds like my personal experience, curing myself from autoimmune disease.

Re: Inflammation might be the root of preventable disease

#138

In my case, inflammation is a side effect of insulin resistance, like my fellow 83 million Americans with metabolic syndrome. If I can reverse the cause long enough, the liver should stop dumping fat into the adipose tissue and triglycerides may drop.

I did a 5-day fast last month. Water only, 120 hours. In the 30 days since I completed the fast, my fasting blood glucose has dropped from ~80-90 down to 65-75. I'm concerned about the accuracy of my Freestyle Libre, but it was previously consistent with professional labs. Anyway, a long term fast like the one I did may help improve your insulin resistance; it seems it did for me.

Did you notice any other effects from your fast?

Re: Inflammation might be the root of preventable disease

#139
post #5

Earlier quoted context omitted.

> Critics might suggest that inflammation is just a symptom in these diseases, rather than a cause. But Hotamisligil says, unequivocally, “Chronic inflammation is uniformly damaging and is absolutely causal to the process, because if you interfere with it, you can reverse the pathology.” And this ability to control such diseases simply by reversing inflammation is a biological response, dating far back to the time of…

If you interfere with the inflammation, doesn't that still leave the problem of lipids leaking?

The idea is to also mitigate the source of the inflammation, so you both goes short term and long term.

Re: Inflammation might be the root of preventable disease

#140
post #76
post #26

Earlier quoted context omitted.

How does one know if they are one of the 25% of Americans with "metabolic syndrome"?

Here you go: A comprehensive definition for metabolic syndrome https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675814/ - see Table 1 as the definition can vary, but NCEP ATP III is 3/5 of central obesity, fasting glucose (or high HbA1c), >150 mg/dl of TG, 130/85 mmHg blood pressure. A recent review of 2009-2016 NHANES data concluded that only 12.2% of Americans were in "optimal cardiometabolic health". https://www.lieb…

> >130/85 mmHg blood pressure

Praise the power to define/change definitions of these values...

Post reply on HN