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Inflammation might be the root of preventable disease

harvardmagazine.com

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Re: Inflammation might be the root of preventable disease

#91

Post by Haga »

all_blue_chucks wrote: post #82
andai wrote: post #5

Earlier quoted context omitted.

> Critics might suggest that inflammation is just a symptom in these diseases, rather than a cause. But Hotamisligil says, unequivocally, “Chronic inflammation is uniformly damaging and is absolutely causal to the process, because if you interfere with it, you can reverse the pathology.” And this ability to control such diseases simply by reversing inflammation is a biological response, dating far back to the time of…

Getting off-topic, but how do biologists define the "highness" of an organism?

Complexity, as in complexity of gestation, development and life cycle.

Re: Inflammation might be the root of preventable disease

#92

Post by aszantu »

LinuxBender wrote: post #6

In my case, inflammation is a side effect of insulin resistance, like my fellow 83 million Americans with metabolic syndrome. If I can reverse the cause long enough, the liver should stop dumping fat into the adipose tissue and triglycerides may drop.

keto does that, or even carnivore. Dave feldman does a ton of experiments on this

Re: Inflammation might be the root of preventable disease

#93

Post by house9-2 »

orangecat wrote: post #75
rossdavidh wrote: post #63

My prediction: 1) reducing chronic inflammation by, for example, exercise or eating better food, is proven to have good health effects 2) pharmaceutical companies try to make that into a pill 3) dang, the benefits of the pill are not nearly as big as if you exercise and eat better food, and not nearly as big as our early trials of the drug indicated they would be 4) we must need a different kind of pill

What is your reaction when social conservatives say that there's no need for contraception or STD vaccines, because you can just not have sex unless you're prepared to accept the responsibilities of pregnancy and raising a child?

condom?

Re: Inflammation might be the root of preventable disease

#94

Post by bad_user »

artemisyna wrote: post #40
RobertRoberts wrote: post #34

Earlier quoted context omitted.

That doesn't change the fact that the "cause" of the whole issue is not a symptom. For example, you can get a blood infection from really bad gingivitis. But it's quite a leap to blame inflammation as the "cause" when it's really plaque (or a myriad of other related things). I think this is the foundational problem with health sciences. There is a lot money to be made treating symptoms, very money little to be made c…

I think what the other poster is saying that the bi-products of the inflammation response in themselves can also cause a problem. Yes, the obesity is probably the "cause" in the first place, but telling a person to go on a weight loss diet is going to be a bit late if that's not going to save them before the inflammation kills them. If you've got 2 or 3 different things killing you at once, you're gonna have to deal…

AFAIK 40% of thin people also have health problems from the metabolic syndrome (e.g. CVD, diabetes), whereas 20% of the obese are healthy.

People focus too much on obesity, but obesity is more like a marker rather than a cause (even if it can make things worse by fat cells becoming inflammatory).

And I have to agree with the parent, we have an obsession with treating the symptoms instead of the cause. And there are cases in which treating those symptoms does not reduce the all cause mortality rate

The perfect example is statins. A high LDL-p might in fact be the body’s response to infection and by impairment of LDL particles production or by accelerating clearance, you can end up doing more harm than good, even if a high LDL-p is a good marker for CVD. And then you’ve got a ton of side effects that reduce quality of life, because such pills are a blunt tool with a lot of downstream effects, some of which are unforeseen.

And to put salt to injury there are studies showing that statins don’t reduce the all cause mortality in patients that haven’t suffered a stroke already. Or that even in patients that suffered a stroke, the life extension is measured on average in only a couple of months. Which actually makes a lot of sense if you really think about it.

Re: Inflammation might be the root of preventable disease

#95

Post by rq1 »

LinuxBender wrote: post #9
rq1 wrote: post #8

Earlier quoted context omitted.

Go for keto + IF. It helped a lot of people.

I did. In fact that was a great start, but once you reach a certain point (in having metabolic syndrome), the Keto+IF reaches diminishing returns. It did bring me down 18 inches on the waist. The gut and hypertension will remain. In fact, my hypertension actually went up. To go further requires either Metformin or Berberine. I opted for Berberine, but time will tell.

Congratulations! Keep going!

Adding 20-30mn HIIT sessions fasted right before breaking the fast may help also.

The hypertension may be related in some cases to sodium depletion causing aldosterone production (and cortisol and adrenaline) leading to fluid retention (and potassium excretion).

For this reason some people supplement themselves with sodium/potassium during keto or long term (72h optimally) water fasts.

Re: Inflammation might be the root of preventable disease

#96

Post by aitchnyu »

rossdavidh wrote: post #63

My prediction: 1) reducing chronic inflammation by, for example, exercise or eating better food, is proven to have good health effects 2) pharmaceutical companies try to make that into a pill 3) dang, the benefits of the pill are not nearly as big as if you exercise and eat better food, and not nearly as big as our early trials of the drug indicated they would be 4) we must need a different kind of pill

There will be a terrible proposal plus dangerous pill, like the idea to infuse a burger with statins to nullify the cholestrol https://www.popsci.com/science/article/2010-08/cheeseburgers...

Re: Inflammation might be the root of preventable disease

#97

Post by DoreenMichele »

LinuxBender wrote: post #9
rq1 wrote: post #8

Earlier quoted context omitted.

Go for keto + IF. It helped a lot of people.

I did. In fact that was a great start, but once you reach a certain point (in having metabolic syndrome), the Keto+IF reaches diminishing returns. It did bring me down 18 inches on the waist. The gut and hypertension will remain. In fact, my hypertension actually went up. To go further requires either Metformin or Berberine. I opted for Berberine, but time will tell.

Insulin resistance is related to inadequate protein, not excess fat per se. You may need more muscle, which is partly based on getting the right kind and amount of protein.

Egg whites are the most bioavailable protein. Humans can use about 98 percent of it. I used egg whites to good effect when one of my sons needed more protein for some reason.

Reference:

https://news.ycombinator.com/item?id=8748147

(This is not advice per se. I'm just making conversation and super tired.)

Re: Inflammation might be the root of preventable disease

#98

Post by atomical »

User23 wrote: post #90
atomical wrote: post #71

Earlier quoted context omitted.

Are you saying someone on keto can eat 4,000 calories of butter and not gain weight?

You can drink 4000 calories of ethanol and not gain weight though! It's the only macronutrient with no storage form. From this was derived the infamous lean chicken breast and tequila diet. Biologically impossible to gain fat on that diet. Dietary protein is used as such, very little is converted into glucose and of that virtually none becomes lipids[1]. Never said it's healthy, but you will lose fat. If you're not k…

The people that die have an obsessive behavior (like anorexia or body image issues) that cause them to ignore the side effects.

If you were taking a drug and it made you feel horrible would you take more? Most likely you would stop or at least forego increasing the dosage.

These people didn't die because of dinitrophenol. They died because of an underlying condition. It's an accidental suicide.

Re: Inflammation might be the root of preventable disease

#99

Post by gpickett00 »

gnoppa wrote: post #85
rossdavidh wrote: post #63

My prediction: 1) reducing chronic inflammation by, for example, exercise or eating better food, is proven to have good health effects 2) pharmaceutical companies try to make that into a pill 3) dang, the benefits of the pill are not nearly as big as if you exercise and eat better food, and not nearly as big as our early trials of the drug indicated they would be 4) we must need a different kind of pill

I'd predict the pharmaceutical pill will be damaging! Our body is very smart and heals most things by itself, given the right nutrition.

The first few generations probably will be. But it'll be solved.

Re: Inflammation might be the root of preventable disease

#100

Post by folli »

gnoppa wrote: post #85
rossdavidh wrote: post #63

My prediction: 1) reducing chronic inflammation by, for example, exercise or eating better food, is proven to have good health effects 2) pharmaceutical companies try to make that into a pill 3) dang, the benefits of the pill are not nearly as big as if you exercise and eat better food, and not nearly as big as our early trials of the drug indicated they would be 4) we must need a different kind of pill

I'd predict the pharmaceutical pill will be damaging! Our body is very smart and heals most things by itself, given the right nutrition.

This sounds like some anti-vaxx reasoning.
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