That would be an enormous waste of institutional knowledge and technology (in the form of extant pianos and pianists).
If you're going to make such a drastic change to the piano, at least cut the keyboard into two halves at middle c, then invert both halves.
Now when the right hand starts at what used to be middle c and plays a chromatic scale upward, it's going from high pitches to low pitches. E.g., middle c is now the highest sounding c on the instrument.
(For purposes of this thought experiment, suppose there are two middle c's. I'm describing the middle c to the left below...)
Mirroring that, when the left hand starts at what used to be its middle c and plays a chromatic scale downward in the lower half, it's going from low pitches to higher pitches. That is, what used to be middle c is the lowest sounding pitch.
Benefits:
* when the right hand plays a melody the strongest fingers-- thumb, index, and middle-- are most likely to be playing. The ring finger and pinky-- the weakest fingers-- would be relegated to inner voices most of the time.
* the bass notes-- the most important notes of the accompaniment-- are played with the strongest fingers of the left hand. Again, that's thumb, index, and middle. Ancillary notes, and inner voices of chords, are played with the weaker fingers-- ring and pinky (and possibly middle if thumb is playing the bass note).
That way you vastly improve the ergonomics of the instrument. Otherwise you're just normalizing a big, expensive instrument so that it is guaranteed to be equally uncomfortable for all sizes of hand.