I've been typing dvorak primarily for about 20 years, also since I was in high school, and I highly recommend it. I agree that switching is a pain in the ass. It will make you essentially unable to type for about 2-4 weeks. Ctrl-C/V/X is a valid concern. I fixed it by mapping mouse buttons to copy/paste, and also getting an Advantage2 Kinesis into which I've programming custom keybinding for Undo/Redo/Copy/Cut/Paste.…
Same. I type on my laptop pretty much all day, and am not even close to having an RSI. To me using QWERTY just seems irresponsible, like driving without a seatbelt or something. If you don't use a computer that much then I guess that's one thing, but if you actually use one on a daily basis for your job and are using QWERTY then that just seems like a huge and unnecessary risk for both yourself and your employer/startup.