New pill can deliver insulin
171–180 of 260 posts
Re: New pill can deliver insulin
#172> Once ingested, water dissolves a disk of sugar, using a spring to release a tiny needle made up almost entirely of freeze-dried insulin. The needle is injected into the stomach — which the patient can’t feel, owing to a lack of pain receptors in the stomach. Once the injection has occurred, the needle can break down in the digestive tract. That's some pretty impressive ingenuity. Also sounds kinda terrifying if the…
Re: New pill can deliver insulin
#173Earlier quoted context omitted.
"What doctors and researchers get wrong about diabetes is that pin-pricks and injections are not even remotely bad. I don't know a single diabetic who cares about injections and blood sugar tests. You get used to that within the first week of diagnosis." Dude, you don't know many diabetics then. Companies spend billions of dollars to solve this problem.
I’m Type 1 and I agree with him. Injections are not a problem worth solving for me. It’s the constant mental grind of tight-rope walking blood sugar through balancing food, insulin, exercise, and random body events (that you never quite figure out) that is the problem. Blood sugar testing is an annoyance, but the main problem is not the actual test, but the inadequacy if testing your sugars a few times a day as a met…
a) The morning peak is a dawn phenomenon. Solved with a higher basal setting 3 hours before waking up.
b) Going to sleep with a 100 mg/dl and waking up in the middle of the night with a glucose of 300 mg/dl? Usually because eating fatty and heavy food for dinner. Depending on your meal, a 150% temporary basal or if looping, letting the oref1 super multi bolus to take care of it.
c) Having a cold and suddenly there is no way to keep your glucose levels down? I use AndroidAPS's profile multipliers here. Last time I was sick I set the multiplier to 160%, which means more basal, more insulin for carbs and correction.
d) Doing sports? Get the insulin on board settings right in AndroidAPS, and try to do exercise only when the IoB is back to the base level. Use 0% TBR if needed.
And still I have an alarm almost every night for a hypo/hyper. Soon closing my loop and letting the automation take care of the nightly surprises. It used to work great with my Accu-Chek Combo pump until the pump broke. Now hopefully getting a Dana RS soon, so I can automate lots of things for the software to take care of.
Re: New pill can deliver insulin
#174Earlier quoted context omitted.
> I don't know a single diabetic who cares about injections and blood sugar tests. I'm diabetic and the sole reason I don't check my blood sugar (unless I think something is drastically out of whack) is that it takes me upwards of 30 minutes to do a finger prick for testing. My anxiety skyrockets and nothing I do can tell me that it's not going to be excruciating. Most of the time I end up having my wife do it, which…
Just so you know, those days there are ways to monitor glucose levels without finger pricking, google: glucose monitor without needle. source:RN
Of course this is anecdotal, but the point is that your mileage may vary.
Re: New pill can deliver insulin
#175Earlier quoted context omitted.
Insulin efficacy isn't really an issue until you are about 90+ F, anything below 90 and it will take long enough to breakdown the proteins that you would already be due to swap your infusion set (every 3 to 4 days). But being in Texas, you might exceed 90F at which point, yeah it could go bad really fast. Not a big deal though, just get a cooling wallet for your pump; FRIO seems to be the popular choice https://www.f…
Thanks for the pointer. I have a FRIO, and love it. I wasn't aware that they made FRIOs for pumps.
Personally, I've rarely had an issue with the heat affecting my pump's reservoir - except when I would go skydiving up in the Mojave desert, where temps would reach north of 110 degrees F. Would simply pack it in a bag with a cool pack when I was outdoors, then put it back on once I got to the ground and was back inside.
Since I was in good control, my biggest reason for transitioning to the pump was convenience. I was up to taking 7 injections a day (when I was working from home and couldn't resist the urge to snack). Once I made the switch, I was amazed at the convenience - I could eat almost anything and take the insulin to cover it (of course, moderation is the key here - and knowing how quickly and persistently some foods elevate your blood sugar. For instance, I'd much rather have a snickers bar than Chinese food. The high fat content and the rice carbs wreak havoc on my BG).
Point being, it's well worth looking into it, if you have the means and the desire.
I've been on a Medtronic pump since making the switch, but will likely be jumping over to a Dexcom CGM and compatible pump once my latest pump warranty is up. (I've stopped using the Medtronic CGM due to some hassles with calibration issues; the Dexcom is supposedly more reliable overall).
Regardless, good luck!
Re: New pill can deliver insulin
#176Earlier quoted context omitted.
"You don’t have to curtail your physical activity to avoid hypoglycemia because glucose is portable and durable." Between this and your "humble-brag" on your other post, what I'm led to believe is that you're pretty ignorant on how variable insulin sensitivity and blood sugar management is from individual to individual. I've maintained an A1C of less than 6.5 for more than a decade so I'm the picture of "perfect" con…
I'm like you when I do any activity having insulin on board. I'm a T1 using a pump, and I really like the combination of a pump and CGM for staying away from surprises. I use AndroidAPS to monitor my glucose and insulin on board, taking a temporary basal setting of 0% if needed before any activity, so my insulin on board drops to the base level or a bit below. Soon the insurance replaces my pump to a Dana RS, which s…
The temporary reduction or even suspension of insulin depending on my activity are key in preventing lows for me.
The closed loop pumps are the biggest improvement I've seen for living with T1. There's always lots of promises, but this is one of the few things that really improves my life on a day to day basis and it just keeps getting better.
Re: New pill can deliver insulin
#177Earlier quoted context omitted.
T1 can’t be reversed.
This diet with stopping milk products can. Milk protein with 17 rings similar to beta cells. Body in an attempt to kill milk protein which escapes into blood without breaking down the ring structure also kills beta cells https://www.youtube.com/watch?v=4edofibXOiM watch at 48 mins
From the video:
> If you observe milk protein (casein) under a microscope it will appears as this - there are 17 links in it.
The video says "links", you say "rings". It's a small but important distinction. Proteins are made by linked aminoacids, so sing "link" is a good approximation, but most of them don't look like "rings".
I can't find where the "17" comes from. After a few google searches I found that casein has approximately 210 aminoacids, the number can vary, but it is not 17.
(Also, you can't see a single casein protein under a normal microscope, nor the parts of it. I guess it's only a metaphor, but it makes me suspicious.)
I don't find the part in the video that says that casein escapes to blood. (I didn't try too hard.)
Casein is split in the stomach by the enzymes IIRC they are the regular enzymes that also split the proteins in meat, and other food, not specialized enzymes.
(There is an specialized enzyme for lactose that is an special sugar in milk, but this is not what the video or you say. But if this were dangerous, we'd have a lot of babies with diabetes. Moreover, only some adults produce the enzyme to digest lactose, so it would be easy to test.)
I didn't find a source that says that beta cells have some proteins that are similar to casein. It is posible, but I doubt.
And IIRC most autoinmune diseases, where the body get confused and start to attack some part of it don't go away after you remove the initial agent that causes the reaction. So stopping drinking milk won't stop the reaction.
Re: New pill can deliver insulin
#178Earlier quoted context omitted.
Just so you know, those days there are ways to monitor glucose levels without finger pricking, google: glucose monitor without needle. source:RN
Most (maybe all?) CGMs need to be calibrated regularly with finger pricks. In fact in the case of both the Dexcom G5 (haven't known anyone on the G6) and Medtronic Guardian sensors they can occasionally sort of derp out and ask for multiple calibrations in a row for utterly mysterious reasons. I just asked and my partner says the most times she has had to test to get a Guardian sensor back to normal was seven times i…
Re: New pill can deliver insulin
#179Earlier quoted context omitted.
I test my insulin willingly with no diabetes. One hard squat hurts way more Than either of those activities. I have actually teared up from hard lifts. Needles are just a nuisance. The real downside to beetus is having to think about it constantly, IMO. (And managing it for kids, who don’t have perspective on blood/needles)
Do you mean you test your blood glucose levels, or are you really testing your insulin levels somehow? (I don't know if that's a thing?)
Re: New pill can deliver insulin
#180Earlier quoted context omitted.
Have you tried using the intermediate segments of the finger instead of the fingertips? It makes a big difference for me in pain perception. Drawing blood is a bit harder sometimes but I still prefer that over having to prick the sensitive tips. (Not that I fret over it. Luckily I lost that within a week of doing regular measurements.) Hospital staff is surprised when they see where I draw blood but so far none told…
The suggestion in the manual of the lancet I used was to use the fingers on the less dexterous hand. It seems logical (but may not actually be correct) that you have more precise/sensitive feeling in the dominant pair.