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New pill can deliver insulin

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Re: New pill can deliver insulin

#161

Post by GordonS »

bitexploder wrote: post #11
samcday wrote: post #4

> Once ingested, water dissolves a disk of sugar, using a spring to release a tiny needle made up almost entirely of freeze-dried insulin. The needle is injected into the stomach — which the patient can’t feel, owing to a lack of pain receptors in the stomach. Once the injection has occurred, the needle can break down in the digestive tract. That's some pretty impressive ingenuity. Also sounds kinda terrifying if the…

I test my insulin willingly with no diabetes. One hard squat hurts way more Than either of those activities. I have actually teared up from hard lifts. Needles are just a nuisance. The real downside to beetus is having to think about it constantly, IMO. (And managing it for kids, who don’t have perspective on blood/needles)

Do you mean you test your blood glucose levels, or are you really testing your insulin levels somehow? (I don't know if that's a thing?)

Re: New pill can deliver insulin

#162

Post by tlrobinson »

RPLong wrote: post #16
samcday wrote: post #4

> Once ingested, water dissolves a disk of sugar, using a spring to release a tiny needle made up almost entirely of freeze-dried insulin. The needle is injected into the stomach — which the patient can’t feel, owing to a lack of pain receptors in the stomach. Once the injection has occurred, the needle can break down in the digestive tract. That's some pretty impressive ingenuity. Also sounds kinda terrifying if the…

What doctors and researchers get wrong about diabetes is that pin-pricks and injections are not even remotely bad. I don't know a single diabetic who cares about injections and blood sugar tests. You get used to that within the first week of diagnosis. No, the unpleasant part of being diabetic is having to live every second of your life as an act of weighing how what you're currently doing is going to affect your blo…

This seems like the perfect job for a machine. Is there a reason CGMs and insulin pumps aren't more common? Cost?

Re: New pill can deliver insulin

#163

Post by sioux77 »

airstrike wrote: post #139
dpatru wrote: post #135

Earlier quoted context omitted.

McDougall points out at one point that it's common for people to gain weight after their doctor tells them to lose weight and puts them on insulin. Insulin promotes weight gain.

It doesn't. Eating too much and exercising too little promotes weight gain.

How about you educate yourself before spitting out nonsense: https://www.ncbi.nlm.nih.gov/pubmed/17924864

https://www.joslin.org/info/why_did_i_gain_weight_when_i_sta...

Re: New pill can deliver insulin

#164

Post by pimeys »

bigtunacan wrote: post #122
1123581321 wrote: post #108

Earlier quoted context omitted.

Sure, I replace them periodically. They don’t spoil quickly, though, in the sense that insulin spoils just from being outside too long. You don’t have to curtail your physical activity to avoid hypoglycemia because glucose is portable and durable.

"You don’t have to curtail your physical activity to avoid hypoglycemia because glucose is portable and durable." Between this and your "humble-brag" on your other post, what I'm led to believe is that you're pretty ignorant on how variable insulin sensitivity and blood sugar management is from individual to individual. I've maintained an A1C of less than 6.5 for more than a decade so I'm the picture of "perfect" con…

I'm like you when I do any activity having insulin on board. I'm a T1 using a pump, and I really like the combination of a pump and CGM for staying away from surprises. I use AndroidAPS to monitor my glucose and insulin on board, taking a temporary basal setting of 0% if needed before any activity, so my insulin on board drops to the base level or a bit below.

Soon the insurance replaces my pump to a Dana RS, which supports closed looping with AndroidAPS. Then it's just setting a temporary glucose target to a higher value and the system takes care of the basal rates to keep the glucose from dropping.

The article here is kind of weird. How am I supposed to dose e.g. 0.3 units or 0.75 units of insulin with the pills? The ability for a very fine granularity and the possibility to automate my medication are much more interesting compared to the pills mentioned in the article.

Re: New pill can deliver insulin

#165

Post by lloyddobbler »

bigtunacan wrote: post #105
coldpie wrote: post #34

Earlier quoted context omitted.

Yeah. I've been T1D since I was 13 (now 30) and I can't even imagine what it's like to live without it. It's literally a constant thread in my mind, every waking moment, and a few times a week while I sleep. I carry glucose tablets and a few granola bars on me, and you're right about carrying insulin. Am I likely to eat on this trip, or can I leave it at home so it doesn't spoil? I once failed to bring my insulin on…

Also a T1D here. I once had my test meter go bad on an international trip; by the time I realized it wasn't working I was on a deserted island that was an about a 4-hour boat ride away from the nearest pharmacy, which was closed. Talk about stress levels going through the roof!

> Talk about stress levels going through the roof!

(Which, of course, is EXACTLY what you want to have happen when you have no way of monitoring your BG.) Yikes!

Re: New pill can deliver insulin

#166

Post by coldpie »

paulcole wrote: post #114
RPLong wrote: post #16

Earlier quoted context omitted.

What doctors and researchers get wrong about diabetes is that pin-pricks and injections are not even remotely bad. I don't know a single diabetic who cares about injections and blood sugar tests. You get used to that within the first week of diagnosis. No, the unpleasant part of being diabetic is having to live every second of your life as an act of weighing how what you're currently doing is going to affect your blo…

I just stopped caring and accept that I have to die sometime. I have good A1C control, test regularly, and am very physically active. But thinking about it constantly just drives me nuts so I go about my life and if it's what kills me, so be it. And if in the (hopefully far) future my physical health is compromised to the point that I don't want to deal with it anymore, I'm at peace with that, too.

Don't feel required to answer, but I'm curious, does that mean you just run high (>150mg/dL) all the time? I find being low (<70mg/dL) or high makes me feel physically poor, and keeping in that narrow range is what I mean when I say it takes constant attention.

Re: New pill can deliver insulin

#167

Post by cs02rm0 »

RPLong wrote: post #16
samcday wrote: post #4

> Once ingested, water dissolves a disk of sugar, using a spring to release a tiny needle made up almost entirely of freeze-dried insulin. The needle is injected into the stomach — which the patient can’t feel, owing to a lack of pain receptors in the stomach. Once the injection has occurred, the needle can break down in the digestive tract. That's some pretty impressive ingenuity. Also sounds kinda terrifying if the…

What doctors and researchers get wrong about diabetes is that pin-pricks and injections are not even remotely bad. I don't know a single diabetic who cares about injections and blood sugar tests. You get used to that within the first week of diagnosis. No, the unpleasant part of being diabetic is having to live every second of your life as an act of weighing how what you're currently doing is going to affect your blo…

What doctors and researchers get wrong about diabetes is that pin-pricks and injections are not even remotely bad. I don't know a single diabetic who cares about injections and blood sugar tests. You get used to that within the first week of diagnosis.

My father in law seems fine with the act of injecting itself, but he's very private about his health issues and seems very self conscious about injecting. I've known him about 15 years and he'll always leave the room to inject even in his own home with only family around. I'd imagine this might help someone like him in a small way.

Re: New pill can deliver insulin

#168

Post by bojackstorkman »

RPLong wrote: post #16
samcday wrote: post #4

> Once ingested, water dissolves a disk of sugar, using a spring to release a tiny needle made up almost entirely of freeze-dried insulin. The needle is injected into the stomach — which the patient can’t feel, owing to a lack of pain receptors in the stomach. Once the injection has occurred, the needle can break down in the digestive tract. That's some pretty impressive ingenuity. Also sounds kinda terrifying if the…

What doctors and researchers get wrong about diabetes is that pin-pricks and injections are not even remotely bad. I don't know a single diabetic who cares about injections and blood sugar tests. You get used to that within the first week of diagnosis. No, the unpleasant part of being diabetic is having to live every second of your life as an act of weighing how what you're currently doing is going to affect your blo…

By happenstance I have spent about half of my life living with people with T1D and this post echos pretty much exactly what I have heard over the past decade or two.

A lot of non-t1d folks seem to fixate on the needle/lancet parts of management because it is visceral, but have difficulty grasping the huge amount of stress and responsibility around managing time, activity, boluses, diet etc.

For example, managing stress can itself be stressful. Some people with t1d have sever anxiety, and a panic attack can trigger a cortisol dump into their bloodstream, which in turn causes a significant spike in blood sugar. I once saw a panic attack spike a person from 80mg/dl to over 400 mg/dl with no eating, no pump/infusion site failure, or incorrect basal rate.

Also, concerns about your ability to engage in sexual activity with regard to blood glucose is the furthest thing from a humble brag. It is an issue for many, many diabetics and is often a point of embarassment. Kudos for mentioning it!

Recently my partner (23yrs with t1d) and I made accounts on the twitter-like site called Beyond Type 1 which has actually been a really great community of diabetics (and diabetic-adjacent people like me) sharing their concerns and advice and we have both loved it.

Re: New pill can deliver insulin

#169

Post by dotuser »

dpatru wrote: post #155
SomeCollegeBro wrote: post #132

Earlier quoted context omitted.

I know several Type 2 diabetics who are not (and have never been) obese. While obesity is definitely a cause for the disease, it is not the only cause there is.

I googled "diabetes in thin people" and found the term "skinny fat", slim but with a high percentage of body fat. These are people who may appear to their body to have enough fat stored to survive a tough winter. (This was how McDougall describes the onset of diabetes.) Can people with low body fat get diabetes?

Did you mean, can a person with low body fat get Type 2 diabetes?
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