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New pill can deliver insulin

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Re: New pill can deliver insulin

#121

Post by throwitaway6512 »

cazum wrote: post #27
RPLong wrote: post #18

Earlier quoted context omitted.

Jesus man. Novo has invented and produced more insulin in the last 30 years than any other company or organization. I get that you're disgruntled about the price of insulin; I am, too. But put the blame where it belongs, not on the people who are producing more and more insulin to accommodate more and more diabetic lifestyles and helping to drive the price down rather than up.

Novo Nordisk has yearly profits of somewhere in the neighborhood of 10b a year. Those numbers are partially generated by pricing insulin products out of reach of many people who died from not being able to afford it. Sorry if I don't have a lot of sympathy for them.

25$ at Walmart. I don’t get how people disregard this all the time. I don’t know if any other companies are selling affordable insulin directly to consumers but Novo IS doing just that.

Re: New pill can deliver insulin

#122

Post by bigtunacan »

1123581321 wrote: post #108
bigtunacan wrote: post #107

Earlier quoted context omitted.

"Hypoglycemia has the advantage of being treated with glucose tablets, which don’t spoil and can be stashed everywhere." Umm... glucose tablets do in fact spoil. I've never seen an unopened bottle spoil, but once they are opened they can spoil over time mostly from the humidity. I found this out the hard way.

Sure, I replace them periodically. They don’t spoil quickly, though, in the sense that insulin spoils just from being outside too long. You don’t have to curtail your physical activity to avoid hypoglycemia because glucose is portable and durable.

"You don’t have to curtail your physical activity to avoid hypoglycemia because glucose is portable and durable."

Between this and your "humble-brag" on your other post, what I'm led to believe is that you're pretty ignorant on how variable insulin sensitivity and blood sugar management is from individual to individual.

I've maintained an A1C of less than 6.5 for more than a decade so I'm the picture of "perfect" control and I can tell you that physical activity is a pain in the ass. I'm hypersensitive to insulin during physical activity. When I go to the gym I want zero insulin on board because just 10 minutes on the treadmill could drop me from 160+ to 30. Just walking is enough to cause me to have low blood sugars, so I have to reduce or skip insulin with food accordingly. I'm required to elevate my blood sugar to 200 before I can scuba dive and then I can still only dive for a maximum of an hour because there is too much risk I will pass out and drown.

And then you say, "I am dealing with an issue where I think some of my preferred injection sites are becoming less effective". Preferred injection site? WTF dude? Of course it is becoming less effective, that is why they tell you to constantly change the location. Preferred injection sites are a huge no-no.

Re: New pill can deliver insulin

#123

Post by jameane »

danhon wrote: post #84
visava wrote: post #67

Plant based diet can reverse diabetes ( I and II ). For type I milk products need to be stopped. Take 1% of your bodyweight as fruits. Take 1 % of your body weight as Raw ( uncooked ) vegetables. Take 10% of that vegetable quota as green leafy vegetables. Based on China Study by Colin Campbell. e.g. weight 150 pounds 1.5 pounds fruits before 1 pm 1.5 pounds raw vegetables for the day If you are still hungry you can e…

T1 can’t be reversed.

Exactly. My sister is type 1 because she doesn't have a pancreas. So no diet is going to change that.

Re: New pill can deliver insulin

#125

Post by airstrike »

dpatru wrote: post #118

I just watched a lecture on diabetes by Dr John McDougall last night. He described type 2 diabetes as the body's natural way to limit weight gain. He points out that morbidly obese people are often not diabetic: lack of insulin resistance is what enabled them to keep growing. Viewed this way, diabetes is a sign that a person has reached maximum weight. Giving a person additional insulin at this point is like trying t…

This is extremely myopic...

Once you're diabetic, a lot of "bad things" happen. People don't take insulin then just to continue eating...

Re: New pill can deliver insulin

#126

Post by warrentr »

dpatru wrote: post #118

I just watched a lecture on diabetes by Dr John McDougall last night. He described type 2 diabetes as the body's natural way to limit weight gain. He points out that morbidly obese people are often not diabetic: lack of insulin resistance is what enabled them to keep growing. Viewed this way, diabetes is a sign that a person has reached maximum weight. Giving a person additional insulin at this point is like trying t…

Sadly it's easier to staple stomachs than produce lasting behavior change

Re: New pill can deliver insulin

#127

Post by RPLong »

1123581321 wrote: post #97
RPLong wrote: post #96

Earlier quoted context omitted.

teaching other diabetics to be so preoccupied is dangerous to them because it increases the temptation to give up on the daily routines ^^ Sorry, this makes no sense at all. Maintaining a routine is one way to express a preoccupation with diabetes management!

I mean: there are a few things you need to do each day to manage diabetes. These are important. What you don’t need to do is worry about it between those times. If you convince someone they need to do too much to manage the disease, they’re more likely to give up on the whole thing.

More likely, as measured how? How do you know this? Spending more time thinking about my condition is a great way to improve blood glucose control, at least in my experience.

Re: New pill can deliver insulin

#128

Post by RPLong »

bigtunacan wrote: post #117
RPLong wrote: post #23

Earlier quoted context omitted.

One thing I'm worried about WRT switching to a pump is the impact of heat on insulin. I can't have a Humalog pen exposed to 80+ degree heat for more than a few minutes without it losing efficacy. I live in Texas. What will stop the summer heat from cooking all the insulin in my pump's reservoir while I'm walking down the street? Do you have any thoughts on this? I'd love to have more flexibility.

Insulin efficacy isn't really an issue until you are about 90+ F, anything below 90 and it will take long enough to breakdown the proteins that you would already be due to swap your infusion set (every 3 to 4 days). But being in Texas, you might exceed 90F at which point, yeah it could go bad really fast. Not a big deal though, just get a cooling wallet for your pump; FRIO seems to be the popular choice https://www.f…

Thanks for the pointer. I have a FRIO, and love it. I wasn't aware that they made FRIOs for pumps.

Re: New pill can deliver insulin

#129

Post by theprotocol »

dpatru wrote: post #118

I just watched a lecture on diabetes by Dr John McDougall last night. He described type 2 diabetes as the body's natural way to limit weight gain. He points out that morbidly obese people are often not diabetic: lack of insulin resistance is what enabled them to keep growing. Viewed this way, diabetes is a sign that a person has reached maximum weight. Giving a person additional insulin at this point is like trying t…

How would this be reconciled with significant weight loss often being a symptom of type 2 diabetes?

Re: New pill can deliver insulin

#130

Post by RPLong »

sithlord wrote: post #100
RPLong wrote: post #28

Earlier quoted context omitted.

I'm saying Novo Nordisk produces insulin, and in doing so causes downward pressure on insulin prices thanks to basic economics. (When the supply of a good increases at the same level of demand, price falls.) This is true for both type 1 and type 2 diabetics. In Novo's case, they have two kinds of long-acting insulin analogue taken 1-2 times per day for both T1 and T2; they have to my knowledge the only ultra-long-act…

There are really 2 major makers of insulin Norvo and Elli and another that isnt near as popular, Apidra. Each insurance company has a 'preferred' where you only have 1 choice. So, with that I dont feel like there really is any competition. A good step forward might be to disallow insurance companies from having 'preferred' brands.

Not a bad idea at all. I'd prefer that insurance companies weren't involved at all, but as a second-best option, I'd prefer if the insurance companies allowed the pharma companies to compete with each other for my business!
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