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Consumption of a dark roast coffee blend reduces DNA damage in humans

ncbi.nlm.nih.gov

141–150 of 170 posts

Re: Consumption of a dark roast coffee blend reduces DNA damage in humans

#141

Earlier quoted context omitted.

> you can often find multiple studies supporting its use and multiple studies saying it's harmful. While true and I get your point, there isn't anything inherently wrong with that. We should expect and welcome research with the awareness of vested interests. Afterall it's not surprising for a substance to be beneficial in certain ways yet harmful in other ways. Research from opposing groups will help identify all int…

> We should expect and welcome research with the awareness of vested interests. No, we should ban vested interests from funding research studies and reduce the SnR.

You mean push them into second order vested interest funding?

Re: Consumption of a dark roast coffee blend reduces DNA damage in humans

#142

Earlier quoted context omitted.

I'm generally sceptical of all studies about coffee for this very reason. There's a lot of bullshit studies around food and supplements funded with people with strongly vested interests in selling more product. It's a real problem. For any given supplement, you can often find multiple studies supporting its use and multiple studies saying it's harmful. When it comes to coffee specifically, if you listen to the studie…

Completely - you could also say that reducing DNA damage might actually also decrease immune system surveillance that might be happening causing worse than expected outcomes. Imagine if a lot of cells that might have killed themselves stay alive because of drinking coffee might actually turn out to be a bad thing. We just don't know enough to say for sure and these sort of studies are wildly difficult to get mortalit…

So far mortality and morbidity figures say "meh". It is relatively easy to find good quality observational studies with decent power on this exact subject, they're just not sexy so they do not get quoted in pop science magazines.

Re: Consumption of a dark roast coffee blend reduces DNA damage in humans

#143

Stopped drinking coffee months ago and I have never felt better. Anxiety is down. Sleeplessness is down. General mood is up. Best of all, I no longer get headaches due to Caffeine withdrawal.

The problem with these type of comments is that they never mention how much coffee, and what type of coffee, was consumed before the life-changing decision.

It is pretty much anecdotal evidence.

Re: Consumption of a dark roast coffee blend reduces DNA damage in humans

#144

"Funding This study has been supported by Tchibo GmbH, Hamburg, Germany." Tchibo is a German chain of coffee retailers and cafés known for its range of non-coffee products that change weekly. https://en.wikipedia.org/wiki/Tchibo Number of locations 700 shops (Germany) 300 (rest of world) They might want to make some in-store claims about Dark Roast...

I feel this is an instance of "hate the game not the player". Funding of scientific research should always be good, even if the stakeholders are hoping for a favorable outcome. By it's definition science is merely uncovering the truth and can't be swayed.

The reality however where we don't trust the results (especially around nutrition), the issues with replication of studies, and wrong usage of p-values is the real problem. Perhaps we need to mandate replication studies... I'm not sure what the solution is - but I don't feel blaming the industry is the right approach either. Science has the problem here.

Re: Consumption of a dark roast coffee blend reduces DNA damage in humans

#145

Earlier quoted context omitted.

When I’m not drinking coffee, I’m less forgetful and think more clearly. I’m less anxious and better in tune with my body. I also feel more myself. But I love coffee and am usually consuming it. Thank you for sharing your experience. I’ll need to try taking a break soon.

You're welcome! The taste of coffee is pretty tough to resist, I'll admit! They do make decaffeinated coffee, although I've never tried it myself.

Apparently, decaf still contains about 25% of the normal level of caffeine. I read this in the "Why we sleep" book by Matthew Walker, but haven't double checked.

Basically, that would mean that drinking decaf is not really the same as not drinking coffee.

Re: Consumption of a dark roast coffee blend reduces DNA damage in humans

#146

Earlier quoted context omitted.

> you can often find multiple studies supporting its use and multiple studies saying it's harmful. While true and I get your point, there isn't anything inherently wrong with that. We should expect and welcome research with the awareness of vested interests. Afterall it's not surprising for a substance to be beneficial in certain ways yet harmful in other ways. Research from opposing groups will help identify all int…

I work for a biotech company that publishes peer-reviewed science. We use scientific publishing for marketing purposes, to influence the regulatory environment in our favor, and to look better than our competitors. Some of it is done to a very high standard. But in general, doing science with such predefined strategic objectives results in a corpus of scientific output that is hard to interpret. Essentially this sort…

I think in the current research climate, you can replace "biotech company" with "university department" and most of your statements still hold true.

Many purely academic studies are done with predefined strategic objectives of advancing one's own prestige, only publishing positive results that fit "your narrative", and indeed polluting the literature with results that are at best incremental improvements, at worst regressions made up to look like improvements.

Re: Consumption of a dark roast coffee blend reduces DNA damage in humans

#147

"Funding This study has been supported by Tchibo GmbH, Hamburg, Germany." Tchibo is a German chain of coffee retailers and cafés known for its range of non-coffee products that change weekly. https://en.wikipedia.org/wiki/Tchibo Number of locations 700 shops (Germany) 300 (rest of world) They might want to make some in-store claims about Dark Roast...

Wow, this sounds like the alcohol industry funding research publications which emphasize that consumption of 2 glasses of wine daily is beneficial to health.

Thanks for pointing it out.

Re: Consumption of a dark roast coffee blend reduces DNA damage in humans

#148

Earlier quoted context omitted.

> you can often find multiple studies supporting its use and multiple studies saying it's harmful. While true and I get your point, there isn't anything inherently wrong with that. We should expect and welcome research with the awareness of vested interests. Afterall it's not surprising for a substance to be beneficial in certain ways yet harmful in other ways. Research from opposing groups will help identify all int…

I work for a biotech company that publishes peer-reviewed science. We use scientific publishing for marketing purposes, to influence the regulatory environment in our favor, and to look better than our competitors. Some of it is done to a very high standard. But in general, doing science with such predefined strategic objectives results in a corpus of scientific output that is hard to interpret. Essentially this sort…

Second that

Re: Consumption of a dark roast coffee blend reduces DNA damage in humans

#149
post #140

Earlier quoted context omitted.

> free from corporate interests That won't help. All research is subject to the bias of the researchers. For example, many researchers have been caught fabricating results so they'll get famous. And just because someone is being funded by the government hardly means the government doesn't have a biased interest in the result. Everyone running the government has an agenda that isn't exactly altruistic.

This is funny. Just a while back there was an article posted about how studies SHOULD start out with defined objectives. The argument was that academics are so desperate to publish positive results that they'll draw any positive conclusion, even if it wasn't what the study started out trying to accomplish.

Indeed. What you are describing is p-hacking

https://en.wikipedia.org/wiki/Data_dredging

Re: Consumption of a dark roast coffee blend reduces DNA damage in humans

#150
post #110

I really hate bad science, and this is an example. Springer Science+Business Media (the publisher) does not transfer copyright of the paper from the author to the publisher like many other journals. This begs the question, why isn't this article open access? The primary author, Dorothea Schipp, is a statistics consultant in small town Germany [0] not associated with a University and the blood work was done in Slovaki…

Right. At root, the protocol was not published and the outcomes were not prespecified, ergo this is dogshit.
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