The Link Between Inflammation and Depression? • Hacker News Board

Re: The Link Between Inflammation and Depression?

#51

Post by starbeast » Tue, Dec 25, 2018, 3:52 AM UTC

Bucephalus355 wrote: post #24

This is very important. It’s not yet fully understood, but something is missing yet in our understanding of inflammation. It’s not everything, just like antibiotics weren’t everything, but progress here will mean curing an incredible amount of human suffering. The book linked below, a late 2015 text on Molecular Neuropharmacology, is fascinating. Every chapter has a mention of inflammation and usually ibuprofen. It’s…

Was having a similar discussion about this subject with my brother today, I completely agree on the importance. The shift from it being all in the head to recognizing that in many cases there is a physical and treatable illness going on will be a revolution. And not an easy one either.

Re: The Link Between Inflammation and Depression?

#52

Post by gassiss » Tue, Dec 25, 2018, 4:08 AM UTC

gnulinux wrote: post #48

cageface wrote: post #36

Earlier quoted context omitted.

Sugar and refined carbs can also cause inflammation but I cut those out of my diet years ago. I didn't see the real benefits until I switched to a plant based diet.

I don't want to be that guy again (I've been heavily downvoted in every nutrition threads I contributed in HN), please understand that I'm trying to learn and improve myself. But I'm curious how did you come up with a plant-based diet that's not high in sugar. As far as I know pretty much all (except very few) plant based food are very high in sugar. Especially most fruits have exorbitant amounts of fructose. I usual…

A nutritionist/dietitian would be your best bet. But my 2c about the sugar in fruits, they're not as bad as refined sugar because of the fiber. You have to look at food as a whole, not as macronutrients combined together.

Re: The Link Between Inflammation and Depression?

#53

Post by cageface » Tue, Dec 25, 2018, 4:28 AM UTC

gnulinux wrote: post #48

cageface wrote: post #36

Earlier quoted context omitted.

Sugar and refined carbs can also cause inflammation but I cut those out of my diet years ago. I didn't see the real benefits until I switched to a plant based diet.

I don't want to be that guy again (I've been heavily downvoted in every nutrition threads I contributed in HN), please understand that I'm trying to learn and improve myself. But I'm curious how did you come up with a plant-based diet that's not high in sugar. As far as I know pretty much all (except very few) plant based food are very high in sugar. Especially most fruits have exorbitant amounts of fructose. I usual…

There is a huge difference between complex carbohydrates bound up in natural fiber and refined starches and sugars. The former are the foundation of the healthiest diets around the planet. The latter are unhealthy. The current anti carb hysteria fails to make a distinction between the two.

I think you'll find you can eat plenty of carbs if you stick to whole grain, unprocessed carbs and also avoid oil. I've been on this diet for two years now and I've lost weight and feel amazing.

You can get enough Omega 3 from non animal sources but if you're worried about it you can supplement with algae-derived Omega 3. Fish get it from algae anyway so you're just cutting out the middle man.

I recommend Michael Greger's book "How Not to Die" for a lot more detail on a healthy plant based diet. I think you'll find it a lot easier to eat this way than you might think.

Re: The Link Between Inflammation and Depression?

#54

Post by zzzeek » Tue, Dec 25, 2018, 4:35 AM UTC

kind of a long yakkety article and not much on tangibles. Yes there's a correlation between depression and inflammation, but there's a much bigger bucket of potential factors going on in this area: depression, sedentary lifestyle, sugar intake, obesity, inflammation, gut bacteria, visceral fat, and a whole lot more. As a clinical depression sufferer, if I change any one of those things, all the others change too. So yes keep looking into it but my own anecdotes and reading suggest there's a more complex ecosystem than just "inflamation == depression" going on.

Re: The Link Between Inflammation and Depression?

#55

Post by giardini » Tue, Dec 25, 2018, 5:21 AM UTC

995533 wrote: post #38

auganov wrote: post #26

Earlier quoted context omitted.

Interesting definitely adding this to my reading list for self serving reasons. I independently came to similar ideas about inflammation, mostly because I have to take a lot of Ibuprofen for chronic pain and what works best is taking some preemptively on non painful days. That is, I always tried to think up more reasons for why this isn't a terrible idea.

Ibuprofen may cause ulcers, bleeding, or holes in the stomach or intestine.

Always possible, but I've taken taking 200 mg ibuprofen 2X per day for 30 years w/o a problem. I also take an 81 mg aspirin every night. I take turmeric and cinnamon with my coffee in the morning. If I get a bad headache I take two 325-mg aspirin also.

I have no stomach problems unless I drink too much Starbucks coffee over a 3-day period.

Re: The Link Between Inflammation and Depression?

#56

Post by jesssse » Tue, Dec 25, 2018, 7:28 AM UTC

cageface wrote: post #53

gnulinux wrote: post #48

Earlier quoted context omitted.

I don't want to be that guy again (I've been heavily downvoted in every nutrition threads I contributed in HN), please understand that I'm trying to learn and improve myself. But I'm curious how did you come up with a plant-based diet that's not high in sugar. As far as I know pretty much all (except very few) plant based food are very high in sugar. Especially most fruits have exorbitant amounts of fructose. I usual…

There is a huge difference between complex carbohydrates bound up in natural fiber and refined starches and sugars. The former are the foundation of the healthiest diets around the planet. The latter are unhealthy. The current anti carb hysteria fails to make a distinction between the two. I think you'll find you can eat plenty of carbs if you stick to whole grain, unprocessed carbs and also avoid oil. I've been on t…

Refined sugar is not inherently unhealthy.

Re: The Link Between Inflammation and Depression?

#57

Post by dan_dev_this » Tue, Dec 25, 2018, 7:43 AM UTC

InGodsName wrote: post #14

We don't know about severity of the depression when we say depression. My friend has racing thoughts, feeling tired all time, unable to move, unable to think. Negatives thoughts amplifying to point where nothing no longer makes sense. Can such depression be treated? When she was born, she had a serological conflict. 1. She first recognized it at age 8. 2. Now she's 18 3. Tried sucide at 16 It's not like she doesn't w…

Take a look at neurofeedback, I had a friend with deep depression who was able to recover with that.

Re: The Link Between Inflammation and Depression?

#58

Post by DanBC » Tue, Dec 25, 2018, 12:02 PM UTC

astazangasta wrote: post #39

DanBC wrote: post #18

Earlier quoted context omitted.

Do you know you're listing a paper widely described as one of the most controversial psychology papers? Here's a response, using the same data, but getting different results: https://annals-general-psychiatry.biomedcentral.com/articles... > The results reported here conclude the debate on the efficacy of antidepressants and suggest that antidepressants are clearly superior to placebo. They also suggest that baseline…

I'd expect any paper that shits on an entire field and especially on a massively profitable industry to be controversial. Here is Kirsch's reply to Fountolakis's paper, by the way: https://academic.oup.com/ijnp/article/15/8/1193/659638

Note that in this case it's psychologists calling the paper controversial. Psychologists in BPS, the organisation that put out shit like Understanding Psychosis[0] or Power Threat Meaning Framework[1] - for an anti-psychiatry organisation to call an anti-psychiatry document "controversial" shows the document is pretty poor.

[0]Here are links to critiques of both version of Understanding Psychosis: https://www.nationalelfservice.net/mental-health/psychosis/u...

https://www.nationalelfservice.net/mental-health/schizophren...

[1] Here's a link to critiques of PTMFramework https://www.nationalelfservice.net/mental-health/power-threa...

Re: The Link Between Inflammation and Depression?

#59

Post by LowLevelHacker » Tue, Dec 25, 2018, 1:02 PM UTC

giardini wrote: post #55

995533 wrote: post #38

Earlier quoted context omitted.

Ibuprofen may cause ulcers, bleeding, or holes in the stomach or intestine.

Always possible, but I've taken taking 200 mg ibuprofen 2X per day for 30 years w/o a problem. I also take an 81 mg aspirin every night. I take turmeric and cinnamon with my coffee in the morning. If I get a bad headache I take two 325-mg aspirin also. I have no stomach problems unless I drink too much Starbucks coffee over a 3-day period.

Sounds like you have stomach ulcers, Sir.

Re: The Link Between Inflammation and Depression?

#60

Post by LowLevelHacker » Tue, Dec 25, 2018, 1:02 PM UTC

wolco wrote: post #43

auganov wrote: post #26

Earlier quoted context omitted.

Interesting definitely adding this to my reading list for self serving reasons. I independently came to similar ideas about inflammation, mostly because I have to take a lot of Ibuprofen for chronic pain and what works best is taking some preemptively on non painful days. That is, I always tried to think up more reasons for why this isn't a terrible idea.

tumeric might be more powerful.

Doesn't work, Google it