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The Link Between Inflammation and Depression?

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Re: The Link Between Inflammation and Depression?

#31

Post by tardigraded »

ultimape wrote: post #8
jeklj wrote: post #2

Not only we don’t understand the mechanism causing depression, we don’t really understand (as far as I am aware) why medications work or don’t work. I deal with mild depression sometimes, but this scares me off of considering medication for it. I’ve encountered so many horror stories of withdrawal symptoms... you really need to be at a point of desperation to consider drugs for it, imo.

My first experience with an antidepressant left me feeling quite ill. Ironically, its one of the ones that gets prescribed often because it has little side-effects. Turned out that this wasn't true, and I was one of the small percentage who experienced Discontinuation Syndrome ( https://www.karger.com/Article/FullText/370338 ). Having such a bad reaction to it lead me down a wild goose chase toward finding out the wa…

If you don't mind, could you share some more details on what tests you did, what was causing the depression, and how the tests led you to find out?

Re: The Link Between Inflammation and Depression?

#32

Post by cageface »

One of the best things I've ever done for my mood is to switch to a plant based diet full of natural anti inflammatory foods. I noticed a big lift in my mood after the first week and it's stuck with me almost two years later.

Check this video for more details: https://youtu.be/4xbNNxQZEgA

Re: The Link Between Inflammation and Depression?

#33

Post by _up »

I am a huge fan of "Dr. Berg" on Youtube he helped me a lot with doing Keto/OMAD correct and reducing inflammation. He also has an interesting Video on depression.

The 6 Causes of Depression: https://www.youtube.com/watch?v=OV5OlaPZ6C4

Also fascinating is a lot of interesting medical knowledge he gathers by reading patent applications.

Re: The Link Between Inflammation and Depression?

#34

Post by _up »

cageface wrote: post #32

One of the best things I've ever done for my mood is to switch to a plant based diet full of natural anti inflammatory foods. I noticed a big lift in my mood after the first week and it's stuck with me almost two years later. Check this video for more details: https://youtu.be/4xbNNxQZEgA

Did you also eat less sugar/carbs? Because I think sugar is the main culprit.

Re: The Link Between Inflammation and Depression?

#35

Post by _up »

_up wrote: post #33

I am a huge fan of "Dr. Berg" on Youtube he helped me a lot with doing Keto/OMAD correct and reducing inflammation. He also has an interesting Video on depression. The 6 Causes of Depression: https://www.youtube.com/watch?v=OV5OlaPZ6C4 Also fascinating is a lot of interesting medical knowledge he gathers by reading patent applications.

The 6 main causes he says are btw: Omega3, B12, Vit.D or B1 deficiency, too much Cortisol or Insulin Resistance.

Re: The Link Between Inflammation and Depression?

#36

Post by cageface »

_up wrote: post #34
cageface wrote: post #32

One of the best things I've ever done for my mood is to switch to a plant based diet full of natural anti inflammatory foods. I noticed a big lift in my mood after the first week and it's stuck with me almost two years later. Check this video for more details: https://youtu.be/4xbNNxQZEgA

Did you also eat less sugar/carbs? Because I think sugar is the main culprit.

Sugar and refined carbs can also cause inflammation but I cut those out of my diet years ago. I didn't see the real benefits until I switched to a plant based diet.

Re: The Link Between Inflammation and Depression?

#37

Post by volkl48 »

atomical wrote: post #15
ultimape wrote: post #8

Earlier quoted context omitted.

My first experience with an antidepressant left me feeling quite ill. Ironically, its one of the ones that gets prescribed often because it has little side-effects. Turned out that this wasn't true, and I was one of the small percentage who experienced Discontinuation Syndrome ( https://www.karger.com/Article/FullText/370338 ). Having such a bad reaction to it lead me down a wild goose chase toward finding out the wa…

Genetic tests seem pointless. It's cheaper and faster to take the drug and find out if one is a responder.

The side effects of many of the medications can be quite harsh and severely affect your mental state when they don't agree with you.

The most obvious example of such would be the significant number of people who experience suicidal ideation or commit it/make attempts as a result of going on certain medications.

But at the less extreme end, you're likely looking at least a month or two, more likely 3 or 4 for each medication attempt. That's going on, taking it for long enough to have an effect, going back off, repeat.

With how severe the side effects can be for many, that's enough time to lose a job, fail out of college, etc. And you're asking them to potentially spend years in that cycle to maybe fine something that works.

Re: The Link Between Inflammation and Depression?

#38

Post by 995533 »

auganov wrote: post #26
Bucephalus355 wrote: post #24

This is very important. It’s not yet fully understood, but something is missing yet in our understanding of inflammation. It’s not everything, just like antibiotics weren’t everything, but progress here will mean curing an incredible amount of human suffering. The book linked below, a late 2015 text on Molecular Neuropharmacology, is fascinating. Every chapter has a mention of inflammation and usually ibuprofen. It’s…

Interesting definitely adding this to my reading list for self serving reasons. I independently came to similar ideas about inflammation, mostly because I have to take a lot of Ibuprofen for chronic pain and what works best is taking some preemptively on non painful days. That is, I always tried to think up more reasons for why this isn't a terrible idea.

Ibuprofen may cause ulcers, bleeding, or holes in the stomach or intestine.

Re: The Link Between Inflammation and Depression?

#39

Post by astazangasta »

DanBC wrote: post #18
astazangasta wrote: post #9

Earlier quoted context omitted.

Most medications DON'T work for most people. For example here[1] is a meta-analysis from 2004 of the top 6 antidepressants which finds that 80% of the effect is achieved by placebo, and the remaining effect is statistically, but not clinically, significant (that is, the effect size is tiny). Here[2] is another follow-up that shows that there may be effects only in the most severely-depressed patients. In addition the…

Do you know you're listing a paper widely described as one of the most controversial psychology papers? Here's a response, using the same data, but getting different results: https://annals-general-psychiatry.biomedcentral.com/articles... > The results reported here conclude the debate on the efficacy of antidepressants and suggest that antidepressants are clearly superior to placebo. They also suggest that baseline…

I'd expect any paper that shits on an entire field and especially on a massively profitable industry to be controversial. Here is Kirsch's reply to Fountolakis's paper, by the way: https://academic.oup.com/ijnp/article/15/8/1193/659638

Re: The Link Between Inflammation and Depression?

#40

Post by smnplk »

InGodsName wrote: post #14

We don't know about severity of the depression when we say depression. My friend has racing thoughts, feeling tired all time, unable to move, unable to think. Negatives thoughts amplifying to point where nothing no longer makes sense. Can such depression be treated? When she was born, she had a serological conflict. 1. She first recognized it at age 8. 2. Now she's 18 3. Tried sucide at 16 It's not like she doesn't w…

Pardon me for saying something she has already tried. But here are some ideas.

- put her on a strict meat & veggies only diet (without nightshades) - Look into low dose naltrexon therapy, there is a LDN facebook group where you can ask questions.

Oh and of course, visit many doctors and ask them about treatment.

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