Earlier quoted context omitted.
The simple answer to this problem has been clear for awhile: Make responses to quote tweets opaque to the original author. 1. Bob quotes a tweet from Alice he thinks his followers will find enraging 2. Bob's followers reply to the tweet with predictable outrage and abuse 3. (present system) Twitter becomes unusable for Alice as she is flooded with mentions from all of the angry and abusive replies to Bob's quote 3. (…
It might improve things marginally but at this point it's just an arm's race. Furthermore the people who will manage to work around these limitations will also probably be the more radicalized fringe of the community who are probably the most problematic one as well. It will deter the more moderate and give a larger audience to the radicalized. Look at how people on Reddit, 4chan and elsewhere manage to identify Twit…
"people on Reddit, 4chan and elsewhere manage to identify Twitter accounts from anonymized screenshots in mere minutes in order to have a constructive discussion".
I assume you mean doxing and stalking. These are the instigators and manipulators... maybe they're the dangerous harassers, but most of the mob can't be bothered.