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Infectious Theory of Alzheimer's Disease Draws Fresh Interest

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Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#71

Post by msie »

subcosmos wrote: post #63
spraak wrote: post #49

Another theory is that Alzheimer's is a vascular disease [1] [2] [3] [4] [5] [6], i.e. atherosclerosis of the brain. [1] https://www.ncbi.nlm.nih.gov/pubmed/12480752 [2] https://www.ncbi.nlm.nih.gov/pubmed/24489130 [3] https://www.ncbi.nlm.nih.gov/pubmed/23239205 [4] http://www.ncbi.nlm.nih.gov/pubmed/20695015 [5] http://www.ncbi.nlm.nih.gov/pubmed/15699381 [6] http://www.ncbi.nlm.nih.gov/pubmed/23204143

This would make sense. HerpesVirus has been shown to cause atherosclerosis as well, in humans. The connection? Herpes binds to the APOE gene sitting on cholesterol-carrying LDL particles .... https://medium.com/@InfinoMe/cholesterol-have-we-shot-the-me... I spent 3 years in one of the nations top alzheimers centers. It is still shocking to me how some of the seasoned veteran professors in the field are both unfamilia…

So maddening to hear that! The funding should be diverse enough not to go to all the veterans.

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#72

Post by eganist »

colordrops wrote: post #60
bryant wrote: post #56

Earlier quoted context omitted.

No, sadly. Just a vaccine for varicella.

So how do you explain the results: "Results: From 2005 through 2011, for the 24 anti-VZV vaccinated patients, the average number of herpes relapses decreased to 0, correlated with an increased anti-VZV antibody level and clinical recovery of all patients, whereas no improvement was observed for the 26 nonvaccinated herpes patients."

A cure for herpes means the excision of viral DNA from the infected cells. Herpes is one of those viruses that stays with a person for life by means of establishing persistence with DNA insertion.

Because of this, any cure will probably rely on CRISPR/Cas9 or variants of this process. E.g. https://www.ncbi.nlm.nih.gov/pubmed/29844277

What you're drawing attention to there, if I'm reading it correctly, is that the presence of the antibodies resulting from the vaccine enables an immune response to consistently check an outbreak just as it's starting, potentially mitigating an outbreak before one becomes visibly apparent.

But I'm probably not reading it correctly. All I'm confident in is that anything short of literally cutting the viral DNA out of the infected cells won't actually cure an infection.

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#73

Post by flocial »

nikkwong wrote: post #69

Lots of information out there. I feel as though my mother who I love dearly might be starting to experience the first stages of alzheimers. She's healthy, but otherwise not doing anything to take care of the condition. Given the current stage of research/etc, what could I do to best protect her? Should I be pushing her towards certain docs or clinical studies? Any direction would be appreciated. We live in Seattle.

Eat more curry is one.

https://www.express.co.uk/news/uk/909678/dementia-cure-curcu...

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#74

Post by extrapickles »

JumpCrisscross wrote: post #62
saidajigumi wrote: post #53

Earlier quoted context omitted.

There are indeed excellent facilities for elder care. But there are many horrific ones, and the difference between them can be hard for outsiders to determine (whether for families, or for yourself). Case in point: My parents had one hell of a time finding good care for my grandfolk (incl. siblings of grandparents). In their state, there is an entire industry of corrupt nursing homes, which also have all sorts of "aw…

> quick turnover and higher profits Why would turnover increase profits for a nursing home?

Some also charge a $80k+ admittance fee. They try and make it sound nice by saying the fee is so they will never kick them out if they run out of money.

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#75

Post by pvaldes »

subcosmos wrote: post #63
spraak wrote: post #49

Another theory is that Alzheimer's is a vascular disease [1] [2] [3] [4] [5] [6], i.e. atherosclerosis of the brain. [1] https://www.ncbi.nlm.nih.gov/pubmed/12480752 [2] https://www.ncbi.nlm.nih.gov/pubmed/24489130 [3] https://www.ncbi.nlm.nih.gov/pubmed/23239205 [4] http://www.ncbi.nlm.nih.gov/pubmed/20695015 [5] http://www.ncbi.nlm.nih.gov/pubmed/15699381 [6] http://www.ncbi.nlm.nih.gov/pubmed/23204143

This would make sense. HerpesVirus has been shown to cause atherosclerosis as well, in humans. The connection? Herpes binds to the APOE gene sitting on cholesterol-carrying LDL particles .... https://medium.com/@InfinoMe/cholesterol-have-we-shot-the-me... I spent 3 years in one of the nations top alzheimers centers. It is still shocking to me how some of the seasoned veteran professors in the field are both unfamilia…

Sadly, the requisites to enter in biomedicine research are overhelming.

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#76

Post by vajrabum »

Cortexyme is starting a phase II trial for their drug COR388 soon which is a targeted anti-microbial for a specific organism which they have identified as Alzheimer's related and believe is the cause of Alzheimers. They should have some results in the next year or so. See here for more info.

https://www.cortexyme.com/news

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#77

Post by saidajigumi »

JumpCrisscross wrote: post #62
saidajigumi wrote: post #53

Earlier quoted context omitted.

There are indeed excellent facilities for elder care. But there are many horrific ones, and the difference between them can be hard for outsiders to determine (whether for families, or for yourself). Case in point: My parents had one hell of a time finding good care for my grandfolk (incl. siblings of grandparents). In their state, there is an entire industry of corrupt nursing homes, which also have all sorts of "aw…

> quick turnover and higher profits Why would turnover increase profits for a nursing home?

Often what another poster said: there's a large admittance fee and/or you sign all of your assets over. Combined with the Medicare/Medicaid issues cited by another sibling post, there's a strong financial disincentive to have residents live longer.

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#78

Post by subcosmos »

pvaldes wrote: post #75
subcosmos wrote: post #63

Earlier quoted context omitted.

This would make sense. HerpesVirus has been shown to cause atherosclerosis as well, in humans. The connection? Herpes binds to the APOE gene sitting on cholesterol-carrying LDL particles .... https://medium.com/@InfinoMe/cholesterol-have-we-shot-the-me... I spent 3 years in one of the nations top alzheimers centers. It is still shocking to me how some of the seasoned veteran professors in the field are both unfamilia…

Sadly, the requisites to enter in biomedicine research are overhelming.

Nada - most hospitals really need computational help. If you come in and have machine learning chops, you can do can even do better financially than most bench biologists.

Starting your way in IT and working into a data science role is definitely possible, regardless of credentials. It's all a matter of finding the right lab and project.

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#79

Post by nikkwong »

flocial wrote: post #73
nikkwong wrote: post #69

Lots of information out there. I feel as though my mother who I love dearly might be starting to experience the first stages of alzheimers. She's healthy, but otherwise not doing anything to take care of the condition. Given the current stage of research/etc, what could I do to best protect her? Should I be pushing her towards certain docs or clinical studies? Any direction would be appreciated. We live in Seattle.

Eat more curry is one. https://www.express.co.uk/news/uk/909678/dementia-cure-curcu...

Thank you.

Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest

#80

Post by [deleted] »

Spooky23 wrote: post #30
sandworm101 wrote: post #27

Earlier quoted context omitted.

And you have fallen into a different statistics trap. The number that matters isn't the cost of treating the patient. What matters is the increased lifetime costs of a paticular disease over the average. We all have to die of something. Diseases like lung cancer are cheap. The patients are either cured or dead relatively quickly. Demential is slow. Costs pile on for decades, starting often with forced early retiremen…

Nursing homes are among the cruelest and most in humane institutions, worse than prison in many ways. Anything that avoids nursing home days is worth it’s weight in gold.

[deleted]
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