This, like Cancer, is a multi billion dollar industry. There is no cure because there is too much incentive to make money, and too much incentive to make regulation. Lots of government and private industry jobs depend on these not getting solved. Nothing can fix it, ever.
Infectious Theory of Alzheimer's Disease Draws Fresh Interest
61–70 of 96 posts
Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest
#62Earlier quoted context omitted.
I have worked in many as a care aid providin direct care to residents. I worked for 7 years in one facility that worked with advanced Alzheimer's and dementia like condition clients. I would not describe the nursing home as cruel or in-human, though to a person with sound mind it certainly would. The people who resided there simply could not live alone. They would soon be seriously hurt or die. So yes when they enter…
There are indeed excellent facilities for elder care. But there are many horrific ones, and the difference between them can be hard for outsiders to determine (whether for families, or for yourself). Case in point: My parents had one hell of a time finding good care for my grandfolk (incl. siblings of grandparents). In their state, there is an entire industry of corrupt nursing homes, which also have all sorts of "aw…
> quick turnover and higher profits
Why would turnover increase profits for a nursing home?
Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest
#63Another theory is that Alzheimer's is a vascular disease [1] [2] [3] [4] [5] [6], i.e. atherosclerosis of the brain. [1] https://www.ncbi.nlm.nih.gov/pubmed/12480752 [2] https://www.ncbi.nlm.nih.gov/pubmed/24489130 [3] https://www.ncbi.nlm.nih.gov/pubmed/23239205 [4] http://www.ncbi.nlm.nih.gov/pubmed/20695015 [5] http://www.ncbi.nlm.nih.gov/pubmed/15699381 [6] http://www.ncbi.nlm.nih.gov/pubmed/23204143
This would make sense. HerpesVirus has been shown to cause atherosclerosis as well, in humans. The connection? Herpes binds to the APOE gene sitting on cholesterol-carrying LDL particles ....
https://medium.com/@InfinoMe/cholesterol-have-we-shot-the-me...
I spent 3 years in one of the nations top alzheimers centers. It is still shocking to me how some of the seasoned veteran professors in the field are both unfamiliar with the 20 years of viral literature behind Alzheimers, but that they also completely write it off as being unlikely. Curing alzheimers starts with curing the old dogma pervasive in the field.
Incidentally, the time is now for young hackers to get into biomedicine. We need you.
Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest
#64Earlier quoted context omitted.
There are indeed excellent facilities for elder care. But there are many horrific ones, and the difference between them can be hard for outsiders to determine (whether for families, or for yourself). Case in point: My parents had one hell of a time finding good care for my grandfolk (incl. siblings of grandparents). In their state, there is an entire industry of corrupt nursing homes, which also have all sorts of "aw…
> quick turnover and higher profits Why would turnover increase profits for a nursing home?
The quick turnovers are likely caused by being understaffed and underpaying employees. Both of which would help with profits.
Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest
#65Alzheimer's is the cruelest of illnesses and the loved ones of the victims suffer as much as the victims. The allure of this theory, in my view, is that if you could somehow turn this into a treatment, people would give you whatever money you demanded for it. You want $200,000? We'll find it, somehow, just make Mom remember who I am, please.
> The allure of this theory, in my view, is that if you could somehow turn this into a treatment, people would give you whatever money you demanded for it. You want $200,000? We'll find it, somehow, just make Mom remember who I am, please. Experts please correct me if I'm wrong, but even if this theory were to be proven true, how could it help anyone once the damage is done?
The adult brain has some limited ability to recover from injuries. It's quite possible that if an aggravating factor was removed, Alzheimer's patients could slowly improve.
Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest
#66Earlier quoted context omitted.
There are indeed excellent facilities for elder care. But there are many horrific ones, and the difference between them can be hard for outsiders to determine (whether for families, or for yourself). Case in point: My parents had one hell of a time finding good care for my grandfolk (incl. siblings of grandparents). In their state, there is an entire industry of corrupt nursing homes, which also have all sorts of "aw…
> quick turnover and higher profits Why would turnover increase profits for a nursing home?
Most people don’t have a lot of assets. Medicare pays a decent reimbursement rate that declines over time. Medicare also pays for rehab tied to outcome, and nursing homes tend to have bad outcomes so they only get 90-180 days of that.
Once you’re off Medicare, if you cannot private pay (or once you run out of cash), you go on Medicaid. The county seizes your remaining assets and pays a very low reimbursement.
The ideal nursing home patient either has cash or requires short term rehab, and either leaves or dies in <180 days. The old ladies watching judge Judy or playing checkers are low margin.
Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest
#67Another theory is that Alzheimer's is a vascular disease [1] [2] [3] [4] [5] [6], i.e. atherosclerosis of the brain. [1] https://www.ncbi.nlm.nih.gov/pubmed/12480752 [2] https://www.ncbi.nlm.nih.gov/pubmed/24489130 [3] https://www.ncbi.nlm.nih.gov/pubmed/23239205 [4] http://www.ncbi.nlm.nih.gov/pubmed/20695015 [5] http://www.ncbi.nlm.nih.gov/pubmed/15699381 [6] http://www.ncbi.nlm.nih.gov/pubmed/23204143
It's more recently called diabetes type 3, too, which would also make some sense, as diabetes and atherosclerosis have also been linked.
Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest
#68Alzheimer's is the cruelest of illnesses and the loved ones of the victims suffer as much as the victims. The allure of this theory, in my view, is that if you could somehow turn this into a treatment, people would give you whatever money you demanded for it. You want $200,000? We'll find it, somehow, just make Mom remember who I am, please.
If anyone has been looking at TauRX's phase 3 trials[1], methylene blue is ridiculously cheap, has been around for 100 years and stops Alzheimers progression better than any other drug. Tau is working on a slightly modified form that is basically putting it in a capsule and they'll sell it for $50 a pill probably, but that's the only way that anyone will believe it actually works. Methylene blue is a potent antimicro…
Other studies of mild to moderate Alzheimer's patients showed no improvement with Methylene blue,
https://www.alzforum.org/news/conference-coverage/first-phas...
Also I'd generally be more skeptical as the green urine it produces could be a strong placebo enhancer that is hard to control against.
Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest
#69Lots of information out there. I feel as though my mother who I love dearly might be starting to experience the first stages of alzheimers. She's healthy, but otherwise not doing anything to take care of the condition. Given the current stage of research/etc, what could I do to best protect her? Should I be pushing her towards certain docs or clinical studies? Any direction would be appreciated. We live in Seattle.
Re: Infectious Theory of Alzheimer's Disease Draws Fresh Interest
#70Another theory is that Alzheimer's is a vascular disease [1] [2] [3] [4] [5] [6], i.e. atherosclerosis of the brain. [1] https://www.ncbi.nlm.nih.gov/pubmed/12480752 [2] https://www.ncbi.nlm.nih.gov/pubmed/24489130 [3] https://www.ncbi.nlm.nih.gov/pubmed/23239205 [4] http://www.ncbi.nlm.nih.gov/pubmed/20695015 [5] http://www.ncbi.nlm.nih.gov/pubmed/15699381 [6] http://www.ncbi.nlm.nih.gov/pubmed/23204143
There actually exists a type of Dementia called Vascular Dementia too. https://en.wikipedia.org/wiki/Vascular_dementia