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Eating in 10-hour window can override disease-causing genetic defects

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Re: Eating in 10-hour window can override disease-causing genetic defects

#51

Post by Angostura »

ainar-g wrote: post #41
projectramo wrote: post #8

Another major victory in mankind’s long quest to render mice immortal.

For anyone wondering about what's wrong with mouse testing, here is a funny but informative video on the subject[1]. One highlight: >After a drug is confirmed as safe and efficacious in preclinical studies, it is tested in healthy human volunteers for first in man trials. In 2006, a phase I clinical study was conducted for a CD28 superagonist antibody TGN1412 in six human volunteers. After very first infusion of a do…

Which shows that mice are an imperfect model, not that they don't have substantial value.

Re: Eating in 10-hour window can override disease-causing genetic defects

#52

Post by anoncoward111 »

Angostura wrote: post #51
ainar-g wrote: post #41

Earlier quoted context omitted.

For anyone wondering about what's wrong with mouse testing, here is a funny but informative video on the subject[1]. One highlight: >After a drug is confirmed as safe and efficacious in preclinical studies, it is tested in healthy human volunteers for first in man trials. In 2006, a phase I clinical study was conducted for a CD28 superagonist antibody TGN1412 in six human volunteers. After very first infusion of a do…

Which shows that mice are an imperfect model, not that they don't have substantial value.

Right? It's like, "Woman dies from water overdosw during radio contest, therefore all water consumption is at very least unhealthy"

Re: Eating in 10-hour window can override disease-causing genetic defects

#53

Post by Angostura »

SwellJoe wrote: post #23

I've been on an intermittent fasting schedule (I usually do 16/8) for about a year and a half. I lost some weight during the first several months, but have leveled off to a reasonable weight (which is probably 10 pounds heavier than I'd like, but ~25 pounds lighter than when I started intermittent fasting). Overall, I don't see any dramatic changes. Lots of people claim to see a significant difference, usually positi…

I too do 16:8 and am in my 50s. I'm losing moderate amount of weight, but probably because it has made me think about evening snacking. As with you, it's low risk, not a particular problem for me to carry out and cost neutral at worst.

The only problem is I tend to feel drowsy after lunch at work :)

Re: Eating in 10-hour window can override disease-causing genetic defects

#54

Post by oh_sigh »

throwaway66666 wrote: post #48
oh_sigh wrote: post #40

Earlier quoted context omitted.

It sounds like you were just starving yourself. I'm going to guess that you weren't eating 2-5 days worth of food whenever you chose to eat? I'm sorry but going that long without eating just doesn't make any sense. Did you/your family only have the ability to buy/acquire one meal at a time or what?

No, I was living alone while going to school. I would starve myself so I could save more money. What is the difference between X day fasts and what I did? I am not trying to claim that fasting doesn't work, just noting my personal experience. For me it certainly worked in the sense that I saw the fakeness of "if you don't eat for X days you get super hungry or weak/sick/you die", I was perfectly ok.. but not amazing.

The difference is that fasters aren't intentionally calorie restricting, they are just time restricting their eating. It sounds like you may have been starving yourself(getting fewer calories than you needed), and also time restricting yourself.

Re: Eating in 10-hour window can override disease-causing genetic defects

#55

Post by coldtea »

yostrovs wrote: post #21
colechristensen wrote: post #18

Earlier quoted context omitted.

"I guess doing strange things to rodents and measuring the outcomes is useful, but going so far as to turn it into health advice for humans is absurd." 16 days ago I said that. This one seems a little more legitimate and a target for further research. Animal models are a start, but you shouldn't use them to give definitive advice or conclusions. The headline is " Eating in 10-hour window can override disease-causing…

Interestingly, though, this correlates with the common idea of not eating in the evening. Say you have breakfast at 8, you don't eat after 6pm, when you have your dinner. 10 hours of eating right there with snacks and all. I'm guessing that's why the study was tried, though what do I know.

And yet some of the population that live more than everybody else of the planet, e.g. the population of Icaria, eat whenever they like, and its very common to eat at late hours (after 10pm).

Then again they have a few other tricks up in their sleeves: they eat lots of quality plants grown in their island, they have minimal work related stress (or, for that matter, minimal work in general), leave close to calming nature (including sea), have good community ties, and are legendary for not giving a fuck...

Re: Eating in 10-hour window can override disease-causing genetic defects

#56

Post by coldtea »

mark_l_watson wrote: post #13
allforJesse wrote: post #6

Interesting how this time restricted eating seems to differ from perspectives in the intermittent fasting community. Intermittent Fasting folks tend to espouse avoiding caloric intake for long periods of time every day, but they're fine with black coffee/tea (since it doesn't trigger an insulin response). But here Dr. Panda seems to believe that even coffee would compromise the fasting window: https://youtu.be/iywhaz…

I just signed up and installed their iOS app. You are correct: drinking coffee or tea in the morning starts the non-fasting period. This will be rough for me because I usually have coffee at 5:30am, read or study for 90 minutes, then have breakfast and go to work. I will shift my morning coffee to when I have breakfast. I have been non-fasting and fasting with an even split of 12 hours / 12 hours per day, so this wil…

>This will be rough for me because I usually have coffee at 5:30am, read or study for 90 minutes, then have breakfast and go to work.

Or you can ignore their advice (others advice otherwise anyway), and still drink coffee as part of your fasting...

It's not like any of this is particularly scientific...

Re: Eating in 10-hour window can override disease-causing genetic defects

#57

Post by coldtea »

will_brown wrote: post #12
allforJesse wrote: post #6

Interesting how this time restricted eating seems to differ from perspectives in the intermittent fasting community. Intermittent Fasting folks tend to espouse avoiding caloric intake for long periods of time every day, but they're fine with black coffee/tea (since it doesn't trigger an insulin response). But here Dr. Panda seems to believe that even coffee would compromise the fasting window: https://youtu.be/iywhaz…

Definitely if you trigger insulin response it is safe to say you break a fast, but any caloric intake breaks the fast, even without insulin response. I’m not sure that video supports your conclusion that coffee/tea breaks the fast, seems to me it’s more of a maybe . I personally appreciated the acknowledgement of the microbiome. The idea that simply...we don’t know and don’t understand the interactions of the microbi…

>Definitely if you trigger insulin response it is safe to say you break a fast, but any caloric intake breaks the fast, even without insulin response.

"Breaks a fast" is meaningless without specifying what we mean by that.

If we mean "breaking fast = you eat something with calories" then yes, but then it's a tautology.

If we mean "insulin response", then there would be other criteria for breaking a fast.

Even traditional religious and cleansing fasts allowed lots of different foods (e.g. plants) and were still considered fasts.

Fast is not some one-size-fits-all word that means "absolutely no calories" during it.

Re: Eating in 10-hour window can override disease-causing genetic defects

#58

Post by coldtea »

nickjj wrote: post #47

I'm kind of surprised this isn't the default for most people. For example let's say you eat dinner at 6-7pm and then goto bed at 11pm. After that you wake up around 7am and then maybe eat breakfast an hour or 2 later. At this point you've gone from about 7pm to 8am or 9am without eating (~13-14 hours) but it fits pretty well into a schedule. Wouldn't you have to really go out of your way to deviate from that? Of cour…

>Wouldn't you have to really go out of your way to deviate from that?

Depends on the country and culture. In these here parts we still go to work at 8am or 9am, but we dine at 10pm or later (going to a restaurant at 11pm is very common, and similarly for eating at home).

Re: Eating in 10-hour window can override disease-causing genetic defects

#59

Post by coldtea »

oh_sigh wrote: post #40
throwaway66666 wrote: post #31

I 've spent 3.5/4 years eating nothing except on the weekends (my undergrad). So I would go for 2-5 days at a time without food. Not because of fasting fads or anything, I didn't even know what fasting was. I was just from a very poor family and if I wanted to go for vacations with my friends or party in the weekend or buy a computer I had to save every penny I could. (that's how I bought my first laptop etc). I woul…

It sounds like you were just starving yourself. I'm going to guess that you weren't eating 2-5 days worth of food whenever you chose to eat? I'm sorry but going that long without eating just doesn't make any sense. Did you/your family only have the ability to buy/acquire one meal at a time or what?

>I'm sorry but going that long without eating just doesn't make any sense.

That would be great news to the lower 1-2 billions in the developing world.

Re: Eating in 10-hour window can override disease-causing genetic defects

#60

Post by coldtea »

yostrovs wrote: post #22
sharmi wrote: post #10

How does 10 hours of eating and 14 hours of fasting translate to humans? The life span of a mouse is much smaller than humans amd their metabolic rate is higher, 4 times that of humans. So I wonder if that would mean a much longer eating window and fasting window for humans.

The sun and the moon spin at rates independent of the lifespan of the animal in question.

And are bot irrelevant when we concern ourselves at changes to metabolic rate and other such processes in different animals.
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