Live data from Hacker News

Eating in 10-hour window can override disease-causing genetic defects

salk.edu

21–30 of 92 posts

Re: Eating in 10-hour window can override disease-causing genetic defects

#21

Earlier quoted context omitted.

A witty quip, and I totally agree with the sentiment, but I'm wondering what other way we have to test hypotheses in vivo . Animal models are pretty key, but my knowledge of the field is incomplete.

"I guess doing strange things to rodents and measuring the outcomes is useful, but going so far as to turn it into health advice for humans is absurd." 16 days ago I said that. This one seems a little more legitimate and a target for further research. Animal models are a start, but you shouldn't use them to give definitive advice or conclusions. The headline is " Eating in 10-hour window can override disease-causing…

Interestingly, though, this correlates with the common idea of not eating in the evening. Say you have breakfast at 8, you don't eat after 6pm, when you have your dinner. 10 hours of eating right there with snacks and all. I'm guessing that's why the study was tried, though what do I know.

Re: Eating in 10-hour window can override disease-causing genetic defects

#22
post #10

How does 10 hours of eating and 14 hours of fasting translate to humans? The life span of a mouse is much smaller than humans amd their metabolic rate is higher, 4 times that of humans. So I wonder if that would mean a much longer eating window and fasting window for humans.

The sun and the moon spin at rates independent of the lifespan of the animal in question.

Re: Eating in 10-hour window can override disease-causing genetic defects

#23
I've been on an intermittent fasting schedule (I usually do 16/8) for about a year and a half. I lost some weight during the first several months, but have leveled off to a reasonable weight (which is probably 10 pounds heavier than I'd like, but ~25 pounds lighter than when I started intermittent fasting).

Overall, I don't see any dramatic changes. Lots of people claim to see a significant difference, usually positive, in energy, strength, mood, sleep, etc. But, I generally think all of those metrics are "about the same" for me. Maybe I'm mildly more energetic because of carrying less weight around. But, I'm also at the age where the effects of aging begin to be noticeable...so, maybe just maintaining levels is progress?

Nonetheless, after several years of research into the topic, and related topics like caloric restriction, a couple of years ago I was convinced that the evidence was compelling enough to make it part of my life and started reducing my eating period each day until I was comfortable with 16 hours of fasting each day (sometimes I'll do 20 or 24, if I'm busy and feel OK). I recommend it to people who ask about it, but not because it's a magical cure for all that ails you. I just think the evidence is strong enough to be worth the minor trade-offs. It isn't a risky decision (with the caveat that it probably isn't appropriate for people with diabetes or hypoglycemia or similar)...none of the science indicates negative results, and nearly all of it indicates positive results to one degree or another. It's pretty much like any other diet decision, e.g. eat more vegetables because you'll probably live longer, not because it'll cure cancer or make you an Olympic athlete.

Re: Eating in 10-hour window can override disease-causing genetic defects

#24
Did the mice which had access to food 24/7 eat more overall than the mice with restricted food access?

If so, then the study seems useless because the results can entirely be explained as excessive eating leads to health problems.

I don't see anything in the article saying how they controlled for quantity of food consumed.

Re: Eating in 10-hour window can override disease-causing genetic defects

#25
post #9

Earlier quoted context omitted.

Middle of the day for largest meal. Try to eat less before bed so liver can detox instead of digest food while u sleep. Also if your a man try working on peacock pose each morning 30 mins before eating (up to 5 mins) to boost digestion , if woman be careful when menstruating

Peacock pose is not exactly for the faint-hearted.

Peacock pose: "[...] oneself is raised like a horizontal stick holding the floor with both palms while the body is supported by the elbows" (Cited Wikipedia entry with image: https://en.m.wikipedia.org/wiki/Mayurasana)

Re: Eating in 10-hour window can override disease-causing genetic defects

#26

I've been on an intermittent fasting schedule (I usually do 16/8) for about a year and a half. I lost some weight during the first several months, but have leveled off to a reasonable weight (which is probably 10 pounds heavier than I'd like, but ~25 pounds lighter than when I started intermittent fasting). Overall, I don't see any dramatic changes. Lots of people claim to see a significant difference, usually positi…

Are you doing LCHF (low carb high fat) as well or just IF (intermittent fasting)?

Re: Eating in 10-hour window can override disease-causing genetic defects

#27
Is it possible that with economic affluence of the West, overconsumption is harmful?

It used to be that there would be days where our ancestors would not be able to bring home any meat so fasting probably was built in as part of our metabolism process.

It was only in the past 100 years that we've seen mass produced sugary food and drinks.

Like the diet difference is painfully obvious when you go to Japan's 7-11. Healthy stuff all around compared to deep fried fast food.

Some days I will only eat 1 meal, and I honestly feel great. The biggest difference being I have way more energy and just feel "light".

These days I've converted to mostly Korean food consisting of rice and veggie side dishes incl kimchi of course. I've lost 4kg within 3 weeks just by changing diet.

Of course can't resist the burger and fries once in a while....but eating primarily Korean food because I'm Korean I realize is the wise choice....our ancestors have been eating the same stuff for millenias so it's probably "right" for my metabolism.

there's a study that showed East-Asian men living in North America have high rate of prostate related issues which has traditionally never been prevalent in East Asia...and also the rise of American fast food chains have collectively made the world a lot less healthier with the increase of diabetes and obesity.

Re: Eating in 10-hour window can override disease-causing genetic defects

#28
post #10

How does 10 hours of eating and 14 hours of fasting translate to humans? The life span of a mouse is much smaller than humans amd their metabolic rate is higher, 4 times that of humans. So I wonder if that would mean a much longer eating window and fasting window for humans.

The sun and the moon spin at rates independent of the lifespan of the animal in question.

Yes, but the effect of food restriction have more pronounced effect in mice vs humans. So, we cannot expect the same efficacy in humans when fasting for the same periods.

""" Fasting of mice for 48 h (which causes ∼20% weight loss) or starvation of human volunteers for up to 4 d (which causes [1] https://www.ncbi.nlm.nih.gov/pubmed/28059587

Re: Eating in 10-hour window can override disease-causing genetic defects

#29
post #9

Is it better to eat in the morning or night for humans?

Middle of the day for largest meal. Try to eat less before bed so liver can detox instead of digest food while u sleep. Also if your a man try working on peacock pose each morning 30 mins before eating (up to 5 mins) to boost digestion , if woman be careful when menstruating

Everything you said sounds like bullshit, do you have any source to back it up?
Post reply on HN