Live data from Hacker News

Melatonin: Much More Than You Wanted to Know

lesswrong.com

61–70 of 268 posts

Re: Melatonin: Much More Than You Wanted to Know

#61
post #60

Re dosages - I recently found melatonin in liquid / dropper bottle form at one of my local drugstores, intended to be mixed into a glass of water or similar. The "dosage" is 1 mg, but that requires 4 droppers - so a single dropper is 250 µg, and it's very easy to do less than that (although not with much accuracy). If you don't want to buy from some online nootropics store just to get a 300µg dose, check your local d…

Also if it's cheap enough, you can dump half the water after dilution!

Re: Melatonin: Much More Than You Wanted to Know

#62
post #61
post #60

Re dosages - I recently found melatonin in liquid / dropper bottle form at one of my local drugstores, intended to be mixed into a glass of water or similar. The "dosage" is 1 mg, but that requires 4 droppers - so a single dropper is 250 µg, and it's very easy to do less than that (although not with much accuracy). If you don't want to buy from some online nootropics store just to get a 300µg dose, check your local d…

Also if it's cheap enough, you can dump half the water after dilution!

Yes, that (or mixing a pitcher of 3mg melatonin and measuring a tenth of it each evening, or something) would also work. Anything with liquid seems way less fiddly than trying to split pills into >2 parts, I'm surprised I don't see more liquid melatonin at stores or more people who know that they want a <1mg dose suggesting liquid melatonin.

Re: Melatonin: Much More Than You Wanted to Know

#63
post #42

Melatonin has also shown to help with certain cancers especially breast. Ref: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412427/

No mention of the antioxidant properties of melatonin or its metabolites. https://www.ingentaconnect.com/content/ben/ctmc/2002/0000000... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614697/ https://www.fasebj.org/doi/abs/10.1096/fj.01-0309fje

Or the fact it also appears to have an effect on mesenchymal stem cells. https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-079X.... https://stemcellsjournals.onlinelibrary.wiley.com/doi/abs/10... https://stemcellsjournals.onlinelibrary.wiley.com/doi/abs/10...

Perhaps this is why its called Beauty Sleep?

I also wonder what effect on the sleep pattern these above affects have in the big picture of sleep?

Best sleep I have had in adulthood was water only fasting for 18days recently. The body seems to know what to do to repair itself, perhaps because ever cell has a copy of our DNA in it. There seems to be some knowledge in this DNA that makes cells know what to be and how to perform its individual cellular role for the bigger picture of being part of a body, a bit like individual humans playing their part in a society.

Re: Melatonin: Much More Than You Wanted to Know

#64

Earlier quoted context omitted.

1.75 mg is still almost an order of magnitude higher than the recommended dose of 300 micrograms . Throw your pills away and get these instead: https://www.amazon.com/Sundown-Naturals-Melatonin-300-Tablet...

If I take 300 micrograms I feel groggy the next day. I do half and that's just right. It's crazy people are doing 3-10mg.

it only takes a couple days to lose your tolerance. if you have to use melatonin, try the smallest dose you can

Re: Melatonin: Much More Than You Wanted to Know

#65

Earlier quoted context omitted.

1.75 mg is still almost an order of magnitude higher than the recommended dose of 300 micrograms . Throw your pills away and get these instead: https://www.amazon.com/Sundown-Naturals-Melatonin-300-Tablet...

If I take 300 micrograms I feel groggy the next day. I do half and that's just right. It's crazy people are doing 3-10mg.

Ideally a bedroom needs to be so dark that if you hold you hand up inches away from in front of your nose, you cant see your hand in any way. You may also want to consider good ventilation in the room, if CO2 levels get up to around 700ppm which can happen in a few hours of going to bed, you will also wake up feeling less refreshed and groggy. Its why they have CO2 scrubbers in submarines and why people feel more refreshed when camping under canvas. Sleeping at the back of a large cave doesnt seem so bad now.

Re: Melatonin: Much More Than You Wanted to Know

#69

Earlier quoted context omitted.

>0.5g or 500mcg I hope you mean 0.5 mg not 0.5g because that would be a very big dose!

I think he did mean .5mg since 500ug is .5mg. Still, I'm a bit confused. The bottles I get come in doses of 10mg, I can't imagine taking even just two or three of them in a single night! On the other hand, I'd think 1/20th of my pill (.5mg) would be way too little. After reading this relevant paraphrase from the article: > There have been few studies on sighted young people. One finds that 1 mg works but 0.3 mg doesn…

Honestly for me the ideal dose is 250ug. I take half of a Trader Joe’s 500ug pill.

Melatonin has a U shaped dose curve so you either need a tiny bit or a whole lot to be effective.

500ug leaves me groggy in the morning, 250 is perfect.

Post reply on HN